Chadani Yuhei

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://sites.google.com/s.okayama-u.ac.jp/chadani-lab/

Research field (1)： Molecular biology

Research keywords (6)： translation-associated quality control , regulation of gene expression , noncanonical translation , Nascent polypeptide , translation , ribosome

Research theme for competitive and other funds (9)：

2023 - 2027 タンパク質合成装置の弱点を補強する「潤滑油」的翻訳因子群の機能解析
2023 - 2027 合成途上産物に秘められた拡張型遺伝情報の解読と遺伝子像の再構成
2023 - 2025 翻訳産物自身に秘匿されたコンテクスト型遺伝情報の解読
2020 - 2025 非典型的な翻訳動態の多様性・普遍性と分子機構
2023 - 2024 酵素の安定発現を実現させる「酵素」の解析

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Papers (21)：

Akinao Kobo, Hideki Taguchi, Yuhei Chadani. Nonspecific N-terminal tetrapeptide insertions disrupt the translation arrest induced by ribosome-arresting peptide sequences. The Journal of biological chemistry. 2024. 300. 6. 107360-107360
Yuhei Chadani, Shun Yamanouchi, Eri Uemura, Kohei Yamasaki, Tatsuya Niwa, Toma Ikeda, Miku Kurihara, Wataru Iwasaki, Hideki Taguchi. The ABCF proteins in Escherichia coli individually cope with 'hard-to-translate' nascent peptide sequences. Nucleic acids research. 2024
Yuhei Chadani, Takashi Kanamori, Tatsuya Niwa, Kazuya Ichihara, Keiichi I. Nakayama, Akinobu Matsumoto, Hideki Taguchi. Mechanistic dissection of premature translation termination induced by acidic residues-enriched nascent peptide. Cell Reports. 2023. 42. 12. 113569-113569
Shinobu Chiba, Keigo Fujiwara, Yuhei Chadani, Hideki Taguchi. Nascent chain-mediated translation regulation in bacteria: translation arrest and intrinsic ribosome destabilization. The Journal of Biochemistry. 2023. 173. 4. 227-236
Ayako Yamakawa, Tatsuya Niwa, Yuhei Chadani, Akinao Kobo, Hideki Taguchi. A method to enrich polypeptidyl-tRNAs to capture snapshots of translation in the cell. Nucleic acids research. 2023

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MISC (54)：

茶谷悠平, 伊藤遥介, 丹羽達也, 丹羽達也, 山川絢子, 町田幸大, 今高寛晃, 田口英樹, 田口英樹. 蛋白質の合成過程に潜む途上終結リスクは生物のプロテオームに配列的制約をもたらす. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
茶谷悠平, 上村絵里, 田口英樹. タンパク質の安定的発現を保証する「タンパク質」の解析. 日本遺伝学会大会プログラム・予稿集. 2023. 95th (CD-ROM)
茶谷悠平, 田邉葵, 丹羽達也, 田口英樹. 翻訳停滞とリボソーム不安定化による非典型的翻訳現象の駆動と再構成. 日本蛋白質科学会年会プログラム・要旨集. 2022. 22nd (Web)
丹羽達也, 茶谷悠平, 田口英樹. 定量プロテオミクスを用いた大腸菌GroE依存基質のGroE欠乏条件下における分解機構の解析. 日本蛋白質科学会年会プログラム・要旨集. 2022. 22nd (Web)
田邊葵, 茶谷悠平, 丹羽達也, 丹羽達也, 田口英樹, 田口英樹. 遺伝情報を拡張,再定義する非典型的翻訳の再構成. 日本遺伝学会大会プログラム・予稿集. 2022. 94th (CD-ROM)

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Education (3)：

2009 - 2012 Okayama University The Graduate School of Natural Science and Technology
2007 - 2009 Okayama University The Graduate School of Natural Science and Technology
2003 - 2007 Okayama University Faculty of Science Department of Biology

Professional career (1)：

博士(理学) (岡山大学大学院自然科学研究科)

Work history (5)：

2023/04 - 現在 Okayama University Faculty of Environmental, Life, Natural Science and Technology Associate Professor
2018/04 - 2023/03 Tokyo Institute of Technology Institute of Innovative Research
2016/04 - 2018/03 Tokyo Institute of Technology Institute of Innovative Research
2015/04 - 2016/03 Tokyo Institute of Technology
2012/04 - 2015/03 Japan Society for the Promotion of Science

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