Research keywords (1)：
Diabetes, obesity, lipid modification, nutrients, organ crosstalk, incretin, adipose tissue, NAFLD
Research theme for competitive and other funds (8)：
2022 - 2026 構造特異的胆汁酸シグナルによる新規脂肪肝抑制機構のマルチオミクス解析
2019 - 2022 Roles of KATP channels on the regulation of heat production and metabolism in adipose tissues
2019 - 2022 Mechanism of proliferation, differentiation, and dedifferentiation of pancreatic beta-cells induced by local signals
2018 - 2020 Elucidation of a Novel Fat Depot with Potent Beiging after Cold Exposure
2016 - 2019 Contribution of adipocytes on regulating bile acid metabolism in liver and glucose homeostasis
2016 - 2019 Mechanism of repetitive proliferation and plasticity acquisition of pancreatic beta cells: prerequisites for the maintenance of glucose homeostasis
2013 - 2016 Crosstalk between fat metabolism and insulin signaling in glucose homeostasis: Analysis in fat-sensitive diabetes mice
2011 - 2013 Mechanism of high fat diet-induced hyperglycemia in obesity-resistant mice
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Papers (39)：
Ryo Hatano, Xilin Zhang, Eunyoung Lee, Atsushi Kaneda, Tomoaki Tanaka, Takashi Miki. Mosaic ablation of pancreatic β-cells induces de-differentiation and repetitive proliferation of residual β-cells in adult mice. iScience. 2024. 110656-110656
Eunyoung Lee, Hannelie Korf, Antonio Vidal-Puig. Reply to: “Liver-adipose tissue crosstalk in nonalcoholic fatty liver disease: the emerging role of remnant cholesterol” “BAT activation might improve NAFLD in patients, but this might require developing and/or maintaining functionally relevant levels of BAT mass.”. Journal of Hepatology. 2023
Ikki Sakuma, Hidekazu Nagano, Naoko Hashimoto, Masanori Fujimoto, Akitoshi Nakayama, Takahiro Fuchigami, Yuki Taki, Tatsuma Matsuda, Hiroyuki Akamine, Satomi Kono, et al. Identification of genotype-biochemical phenotype correlations associated with fructose 1,6-bisphosphatase deficiency. Communications biology. 2023. 6. 1. 787-787
Hanna Deguchi-Horiuchi, Sawako Suzuki, Eun Young Lee, Takashi Miki, Noriko Yamanaka, Ichiro Manabe, Tomoaki Tanaka, Koutaro Yokote. Pancreatic β-cell glutaminase 2 maintains glucose homeostasis under the condition of hyperglycaemia. Scientific reports. 2023. 13. 1. 7291-7291
E. Lee, M. Morimoto, T. Miki. Mechanism for anti-diabetic action of eicosapentaenoic acid in the high-fat diet-sensitive diabetes mouse model. DIABETOLOGIA. 2016. 59. S280-S281
