Rchr
J-GLOBAL ID：202101008569263381   Update date: Jul. 29, 2024

Teno Naoki

テノウ ナオキ | Teno Naoki
Affiliation and department：
Hiroshima International University

About Hiroshima International University


Research field  (1)： Pharmaceuticals - chemistry and drug development
Research keywords  (1)： 酵素阻害剤、核内受容体作動薬、核内受容体拮抗薬、構造活性相関
Research theme for competitive and other funds  (2)：
  • 2016 - 2019 Design of the active site-directed plasmin inhibitor oriented to the clinical applications
  • 2012 - 2015 Novel type of plasmin inhibitors: providing insight into P1 moiety
Papers (52)：
  • Yukiko Yamashita, Keigo Gohda, Yusuke Iguchi, Ko Fujimori, Keisuke Oda, Arisa Masuda, Mizuho Une, Naoki Teno. Discovery of FXR/PPARγ dual partial agonist. Bioorganic & Medicinal Chemistry. 2023. 85. 117238-117238
  • Keigo Gohda, Yusuke Iguchi, Arisa Masuda, Ko Fujimori, Yukiko Yamashita, Naoki Teno. Design and identification of a new farnesoid X receptor (FXR) partial agonist by computational structure-activity relationship analysis: Ligand-induced H8 helix fluctuation in the ligand-binding domain of FXR may lead to partial agonism. Bioorganic & Medicinal Chemistry Letters. 2021. 41. 128026-128026
  • Naoki Teno, Yusuke Iguchi, Keisuke Oda, Yukiko Yamashita, Arisa Masuda, Ko Fujimori, Mizuho Une, Keigo Gohda. Discovery of Orally Active and Nonsteroidal Farnesoid X Receptor (FXR) Antagonist with Propensity for Accumulation and Responsiveness in Ileum. ACS Medicinal Chemistry Letters. 2021. 12. 3. 420-425
  • Arisa Masuda, Keigo Gohda, Yusuke Iguchi, Ko Fujimori, Yukiko Yamashita, Keisuke Oda, Mizuho Une, Naoki Teno. N1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR). Bioorganic & Medicinal Chemistry. 2020. 28. 14. 115512-115512
  • Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno. Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts. Molecules. 2019. 24. 22. 4155-4155
ｍore...
MISC (14)：
  • 増田有沙, 井口裕介, 藤森功, 合田圭吾, 山下ユキコ, 手納直規. Structure-activity relationship (SAR) study of farnesoid X receptor (FXR) agonists with N1-substituted benzimidazole scaffold. 日本薬学会年会要旨集(Web). 2021. 141st
  • 増田有沙, 山下ユキコ, 井口裕介, 小田啓祐, 藤森功, 合田圭吾, 手納直規. Comprehensive understanding of structure-activity relationship of farnesoid X receptor (FXR) antagonists: Evaluation of pharmacokinetics profile and distribution toward the target tissues. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)
  • 篠原早貴, 井口裕介, 小田啓祐, 山下ユキコ, 合田圭吾, 手納直規, 藤森功. 脂肪細胞分化制御における核内受容体FXRの機能解明. 日本薬学会年会要旨集(CD-ROM). 2019. 139th
  • 増田有沙, 山下ユキコ, 井口裕介, 藤森功, 合田圭吾, 手納直規. Hit-to-lead approachから得られたFarnesoid X receptor(FXR)アンタゴニストの創出と,脂肪細胞分化抑制作用. 日本薬学会年会要旨集(CD-ROM). 2019. 139th
  • 篠原早貴, 井口祐介, 小田啓介, 山下ユキコ, 合田圭吾, 手納直規, 藤森功. 脂肪細胞分化制御における核内受容体FXRの機能と調節機構の解析. 日本生化学会大会(Web). 2019. 92nd
ｍore...
Patents (6)：
  • Preparation of bis(arylamino)pyrimidine derivatives as antitumor agents
  • Preparation of spiro-substituted pyrrolopyrimidines as inhibitors of cathepsin S and/or cathepsin K
  • Preparation of heteroaryl nitriles for treating disorders involving cathepsin K
  • Preparation of pyrrolopyrimidinecarbonitriles as inhibitors of cathepsin K
  • Synthesis of dipeptide nitriles as inhibitors of cysteine cathepsins
ｍore...
Books (2)：
  • 化学構造と薬理作用 : 医薬品を化学的に読む
    廣川書店 2015 ISBN:9784567462419
  • 医薬品開発論
    廣川書店 2010 ISBN:9784567397704
Lectures and oral presentations  (1)：
  • 経口カテプシンK阻害剤の開発 -酵素のsubsite特異性の検討を基にした-
    (第34回 日本臨床免疫学会総会 2006)
Education (3)：
  • 1985 - 1988 Kobe Gakuin University
  • 1983 - 1985 Kobe Gakuin University
  • 1979 - 1983 Kobe Gakuin University The Faculty of Pharmaceutical Sciences Department of Biopharmacy
Work history (8)：
  • 2020/04 - 現在 Hiroshima International University
  • 2014/04 - 現在 Hiroshima International University
  • 2014/04 - 2020/03 Hiroshima International University
  • 2008/10 - 2014/03 Hiroshima International University Faculty of Pharmaceutical Sciences
  • 2001/01 - 2008/09 ノバルティスファーマ株式会社 つくば研究所 創薬化学部 主席研究員
Show all
Awards (1)：
  • 2004/11 - 日本薬学会 医薬化学部会 第12回 日本薬学会 医薬化学部会 ポスター賞 経口カテプシンK阻害剤の開発 -Substrate Libraryを基にしたアプローチ-
Association Membership(s) (3)：
American Chemical Society ,  日本薬学会医薬化学部会 ,  日本薬学会
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