Koba Shinji

コバシンジ | Koba Shinji

Affiliation and department：
Job title： Professor

Research field (1)： Internal medicine - General

Research keywords (7)： heart failure , Geriatric Medicne , physical activity , hypertension , dyslipidemia , atherosclerosis , cardiac rehabilitation

Research theme for competitive and other funds (22)：

2020 - 2024 慢性腎臓病の栄養障害・サルコペニアの発症・進展とエピゲノム異常の関係
2019 - 2024 心大血管リハビリテーションによるHDL機能の改善と再発予防効果の解明
2020 - 2023 MicroRNA-181c as a potential biomarker for efficacy of cardiac rehabilitation in geriatric heart failure
2019 - 2023 Effect of Exercise on Vulnerable Coronary Plaque -Assessment with Optical Computed Tomography-
2018 - 2023 心臓リハビリテーションによるHDL亜分画の変化及び冠動脈イベント回避への影響

2019 - 2022 Investigation of novel vasoactive agents as biomarkers for ischemic heart disease.

2017 - 2021 Beneficial effects of cardiac rehabilitation through mobilazation of inflammatory cytokines

2016 - 2019 Efficacy of Cardiac Rehabilitation on bone marrow aging and immunosenescence in patients with cardiovascular diseases

2016 - 2019 Investigation of new biomarker for atherosclerosis

2015 - 2019 Combined effects of cardiac rehabilitation and ASV on elderly chronic heart failure complicated with sarcopenia

2014 - 2019 Personalized prevention for lifestyle-related diseases in control of reactive oxygen species

2014 - 2019 Exploratory study of diet and nutrient for prevention of fatal cardiovascular disease

2014 - 2017 Investigation of new vasoactive peptides as risk/biomarker for coronary atherosclerosis

2010 - 2012 The study of safe and efficacious for exercise prescription andassessment of cardiac performance determine with heart sound.

2010 - 2012 Therapeutic Strategy of Diabetic Macroangiopathy using the Gut Hormone Incretin

2009 - 2011 Effect of longevity-associated Mitochondrial DNA polymorphism and lifestyle modification on the lifetime of patients with ischemic heart diseases.

2009 - 2011 Impact of exercise therapy on regression of coronary atherosclerotic plaque

2009 - 2010 Analysis of modified low-density lipoproteins in plasma of myocardial infarction

2004 - 2005 Study of adiponectin, structure, functions and clinical meanings.

2001 - 2002 Expression and Role of Inflammatory Cytokines in Acute Myocardial Infarction -usingTNF, IL-1, Il-6 knock out mice-

2000 - 2001 冠動脈形成術後の再狭窄予防-血管平滑筋細胞の増殖制御の分子細胞化学的検討

1999 - 2001 Immunohistochemical and molecular biological studies of vascular smooth muscle cell proliferation after coronary stent implantation

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Papers (290)：

Masanari Kuwabara, Jun Sasaki, Yasuyoshi Ouchi, Shinichi Oikawa, Kiyotaka Nakagawa, Masao Sato, Shinji Koba, Suminori Kono, Tetsunori Saikawa, Hidenori Arai. Higher Cholesterol Absorption Marker at Baseline Predicts Fewer Cardiovascular Events in Elderly Patients Receiving Hypercholesterolemia Treatment: The KEEP Study. Journal of the American Heart Association. 2024. e031865
Teruo Sekimoto, Hiroyoshi Mori, Shinji Koba, Taito Arai, Naoki Matsukawa, Rikuo Sakai, Yuya Yokota, Shunya Sato, Hideaki Tanaka, Ryota Masaki, et al. Assessment of Residual Vasospasm in Patients with Plaque Rupture or Plaque Erosion using Optical Coherence Tomography. Journal of atherosclerosis and thrombosis. 2023
Takayuki Yamaji, Takahiro Harada, Masato Kajikawa, Tatsuya Maruhashi, Shinji Kishimoto, Farina Mohamad Yusoff, Kazuaki Chayama, Chikara Goto, Ayumu Nakashima, Hirofumi Tomiyama, et al. Role of Small Dense Low-density Lipoprotein Cholesterol in Cardiovascular Events in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus Receiving Statin Treatment. Journal of atherosclerosis and thrombosis. 2023
Misato Chimura, Shinji Koba, Yasushi Sakata, Takayuki Ise, Hiroyuki Miura, Ryosuke Murai, Hiroshi Suzuki, Emi Maekawa, Keisuke Kida, Koki Matsuo, et al. Evaluation of the efficacy and safety of an integrated telerehabilitation platform for home-based cardiac REHABilitation in patients with heart failure (E-REHAB): protocol for a randomised controlled trial. BMJ open. 2023. 13. 8. e073846
Nobuyuki Masaki, Takeshi Adachi, Hirofumi Tomiyama, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, et al. Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD-J B study. Physiological reports. 2023. 11. 16. e15786

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MISC (237)：

木庭新治, 横田裕哉, 正司真, 新家俊郎. 急性冠症候群患者のtriglyceride lipaseにおける心臓リハビリテーションの有益な効果. 日本動脈硬化学会総会プログラム・抄録集. 2022. 54回. 196-196
木庭新治, 横田裕哉, 正司真, 新家俊郎. 急性冠症候群患者における安定期のHDL関連抗酸化酵素活性の増加と心臓リハビリテーションの関与. 日本動脈硬化学会総会プログラム・抄録集. 2022. 54回. 221-221
木庭新治, 横田裕哉, 正司真, 角田史敬, 安達太郎, 関本輝雄, 近藤誠太, 辻田裕昭, 塚本茂人, 新家俊郎. 急性冠症候群患者における血清パラオキソナーゼおよびアリールエステラーゼ活性の改善は心臓リハビリテーションとは無関係である(Amelioration in Serum Paraoxonase and Arylesterase Activities in Patients with Acute Coronary Syndrome were not Related to Cardiac Rehabilitation). 日本循環器学会学術集会抄録集. 2022. 86回. PJ06-5
木庭新治, 横田裕哉, 正司真, 角田史敬, 安達太郎, 関本輝雄, 近藤誠太, 辻田裕昭, 塚本茂人, 新家俊郎. 急性冠症候群患者における血清パラオキソナーゼおよびアリールエステラーゼ活性の改善は心臓リハビリテーションとは無関係である(Amelioration in Serum Paraoxonase and Arylesterase Activities in Patients with Acute Coronary Syndrome were not Related to Cardiac Rehabilitation). 日本循環器学会学術集会抄録集. 2022. 86回. PJ06-5
塚本茂人, 新家俊郎, 原田和昌, 宮崎哲朗, 宮本貴庸, 香坂俊, 松下建一, 飯田圭, 武井眞, 松田淳也, et al. 超高齢者(90歳以上)の急性心不全の臨床像の特徴. ICUとCCU. 2021. 45. 別冊. S41-S42

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Lectures and oral presentations (55)：

高中性脂肪血症の動脈硬化性心血管疾患における意義
(第9回日本心血管協会学術集会 2024)
回復期から維持期への移行時期に生じる心臓リハビリテーションの問題点について-アンケート調査結果から-
(第88回日本循環器学会学術集会 2024)
動脈硬化性心血管疾患に対する運動療法の効果
(第24回動脈硬化教育フォーラム 2024)
健康に生きるための(メタボそしてフレイル対策のための)運動療法
(第57回日本成人病(生活習慣病)学会学術集会市民公開講座 2024)
Effect of Cardiac Rehabilitation on triglyceride metabolism in Patients with Acute Coronary Syndrome
(The 60th annual meeting of The Japanese Society of Clinical Physiology 2023)

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Education (2)：

1988 - 1992 Showa University Graduate School Medical Research Division The Third Department of Internal Medicine
1982 - 1988 Showa University School of Medicine

Work history (9)：

2014/03 - 2018/08 Showa University Department of Medicine, Division of Cardiology Associate Professor
2018/08 - Showa University Department of Medicine, Division of Cardiology Professor
2003/06 - 2014/02 Showa University Department of Medicine, Division of Cardiology Assistant Professor
1998/11 - 2003/05 Showa University The Third Department of Internal Medicine Instructor
1997/10 - 1998/10 Ogikubo General Hospital Cardiology

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Awards (3)：

2018/07 - The Japanese Association of Cardiac rehabilitation Kimura Noboru Award
2005/09 - 財団法人昭和大学医学振興財団寺本勝人学術賞動脈硬化惹起性小粒子LDLと交感神経活性亢進との関連運動療法による介入効果の検討
2002/06 - 昭和大学医学部同窓会昭和大学医学部同窓会賞リポ蛋白の質的異常、脂肪細胞由来サイトカイン、潜在性食後高脂血症の冠動脈疾患の予後への影響について

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