Research field (3)：
Molecular biochemistry
, Functional biochemistry
, Parasitology
Research keywords (5)：
Metal Complex
, Peptide
, Drug Discovery
, Infectious Diseases
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Research theme for competitive and other funds (8)：
2018 - 2021 The metal element targeting method that enables to the expression of growth inhibitory effects against pathogenic protozoa, and the analyses on their mode-of-actions
2014 - 2017 Development of anti-infective agents focusing on intracellular changes in metal concentration
2012 - 2015 Development of a chemical biosensing technology for exploring bioactive compounds
2011 - 2012 Development of a novel methodology for exploration of peptides that induce cell differentiations
2010 - 2010 新規リボソーム・ディスプレイ法の開発と非天然型ペプチド阻害剤の創出
2007 - 2009 Creation of growth factors binding to metal or ceramic for and their medical applications
2007 - 2008 Construction of a new reaction field by hybrid of metal complex and protein scaffold for creation of artificial metalloenzymes
1999 - 2000 鉄単核パーオキソ錯体の合成と非ヘム鉄酵素モデルへの展開
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Papers (34)：
Takayuki Shinohara, Akira Wada, Masahiro Abe, Nobuko Nakayama, Minoru Nagi, Yoshitsugu Miyazaki. A Novel Zinc-Chelating Compound Has Antifungal Activity Against a Wide Range of Candida Species, Including Multidrug-Resistant Candida auris. JAC-Antimicrob. Resist. 2024. 6,. dlad155.
Takuto Furuhashi, Kensaku Sakamoto, Akira Wada. Genetic Code Expansion and a Photo-Cross-Linking Reaction Facilitate Ribosome Display Selections for Identifying a Wide Range of Affinity Peptides. Int. J. Mol. Sci. 2023. 24,. 15661.
Hiroko Asahi, Mamoru Niikura, Shin-Ichi Inoue, Fujiro Sendo, Fumie Kobayashi, Akira Wada. Dihydroartemisinin Disrupts Zinc Homeostasis in Plasmodium falciparum to Potentiate Its Antimalarial Action via Pyknosis. ACS Infectious Diseases. 2023. 9,. 1303.
Akira Wada, Yuko Umeki, Takeshi Annoura, Yumiko Saito-Nakano. In Vitro and In Vivo Antiamebic Activity of Iron-Targeting Polypyridine Compounds against Enteric Protozoan Parasite Entamoeba histolytica. ACS Infectious Diseases. 2022. 8,. 457.
Akira Wada. Ribosome Display Technology for Selecting Peptide and Protein Ligands. Biomed. Appl. Funct. Nanomat. 2018. C4,. 89.
