ITO Takashi

2019 - 2022 Development of physiological monitoring method by NIRS to evaluate appropriate chest compression at cardiac arrest

2019 - 2022 敗血症関連脳症におけるテトラヒドロビオプテリンの関与とその治療標的としての検討

2018 - 2021 A novel therapeutic strategy targeting HMGB1 isoforms in sepsis

2018 - 2021 Research on the interaction of histones in pathophysiology of sepsis and its application

2018 - 2021 Study of the dynamics of tetrahydrobiopterin in sepsis and the potentiality of BH4 as therapeutic target.

2018 - 2020 Cellular and molecular mechanism of blood sludging/skimming. Causative role of cancer exosomes and their pathophysiological view points

2017 - 2020 Novel therapeutic proposal for DIC/Shock: from Damage-Sensing/-Control to Damage Resolution

2016 - 2018 The mechamism of novel alarmin

2015 - 2018 Therapeutic strategy targeting extracellular histones in sepsis-associated DIC

2016 - 2017 Pathophysiological significance of two types of DAMPs, naked- and exosomal type.

2016 - 2017 Novel simulation technique for diagnosing heparin-induced thrombocytopenia (HIT)

2015 - 2017 Construction of the system of

2014 - 2017 Multi-layered and topological regulatory system of PAMPs and DAMPs. Its relevance in various pathophysiology.

2014 - 2017 The analysis of inflammasome activation in extracellular histones

2014 - 2017 evaluation of organ protective effects of anesthetic agents using extra-cellular histone modification in liver ischemia-reperfusion injury

2015 - 2016 Proposal of novel concept, Exosome cargo as a novel DAMPs delivery system

2014 - 2016 The receptor and inhibitor of Nucleophosmin

2014 - 2015 Extracellular histones stimulate endothelial cells to release unusually-large von Willebrand factor multimer: mechanistic insight into the pathogenesis of lethal coagulopathy

2014 - 2015 PAMPs, DAMPs regulation by thrombomodulin(TM). Probable role of epithelial TM

2012 - 2015 HMGB1-induced vaspressin deficiency contributes to septic shock

2012 - 2015 Contribution of vascular permeability for aging erythrocyte selection in spleen

2013 - 2014 Extracellular histones as a myocardial depressant factor

2013 - 2014 Localization and regulation in reactive sites of DAMPs/PAMPs. Role of ATP from the activated plateles

2012 - 2014 Nucleophosmin: immunoactivity as a novel alarmin

2011 - 2014 Cellular mechanism in thrombin mediated HMGB1 release. Effect of cluster formation of HMGB1 on the cell-surface receptors.

2012 - 2012 A role of extracellular histones as mediators of death in sepsis

2012 - 2012 Comprehensive regulatory system of PAMPs/DAMPs by TM-PC/EPCR system

2010 - 2012 Immunomodulatory effects ofB cell derivedVEGF-A in mice

2011 - 2011 Establishment and dynamism of des-HMGB1, degraded HMGB1 by thrombin-thrombomodulin

2011 - 2011 DAMPs : novel molecular targets for DIC therapy

2009 - 2011 Development of a novel anti-inflammation effect in a Thrombomodulin as a platform type molecule

2006 - 2007 死のメディエーター:HMGB1が臓器不全を引き起こす機序

2005 - 2007 Thrombomodulin : As a regulator of multiple mediators

2005 - 2006 凝固外因系と自然免疫系のクロストークとシナージズム