Rchr
J-GLOBAL ID:202101009046370024
Update date: Apr. 23, 2024
Miyoshi Tomohiro
ミヨシ トモヒロ | Miyoshi Tomohiro
Affiliation and department:
Research field (4):
Molecular biology
, Structural biochemistry
, Bacteriology
, Applied microbiology
Research keywords (10):
感染生物学
, ノンコーディングRNA
, 病原性微生物
, シンバイオシス
, 立体構造解析
, リボソーム
, siRNA/miRNA
, RNAi
, 遺伝子発現制御
, DNAサイレンシング
Research theme for competitive and other funds (21):
- 2022 - 2026 A novel gene expression control system based on the prokaryotic Argonaute
- 2021 - 2024 唾液蛋白質によるステロイド薬の副作用軽減とウイルス誘発性炎症の抑制機構解明
- 2019 - 2022 Association between acquisition of virulence factors and Argonaute protein in bacteria
- 2018 - 2021 ロイコトキシン-受容体相互作用に関する分子基盤の解明と新規歯周炎ワクチンの開発
- 2016 - 2019 Research for the mechanism of DNA silencing using small RNA as a guide strand
- 2019 - 新たな遺伝子解析技術の創生に向けた微生物の DNA サイレンシング機構の解析
- 2015 - 2018 Elucidation of the structural basis for the interaction of the ribosomal stalk protein with aminoacyl-tRNA synthetase
- 2018 - 原核 Argonaute を用いた新たな遺伝子解析技術の実用化に向けて
- 2015 - 2017 A new method for producing site-specific anti-protein antibodies at will
- 2017 - 新たな遺伝子解析技術「RNA-guided DNA silencing」の実用化に向けて
- 2013 - 2016 Structural basis for small RNA functional mechanism in eukaryotes
- 2016 - Recognition mechanism of guide RNA-target DNA heterodupulex by Argonaute
- 2012 - 2015 Ribosomal stalk complex driving translation cycle: molecular basis for high-speed and high-efficiency
- 2015 - Argonaute を使用した新規環境保全システムの創出
- 2014 - タンパク質合成の高効率化へのイノベーション
- 2011 - 2013 Analysis of maturation process of endo -siRNA precursor
- 2012 - タンパク質合成系のエネルギー代謝中心で機能する RNA の機能工学研究
- 2012 - 小分子 RNA 作用マシナリーの解明による環境イノベーション創出のための基盤研究
- 2012 - 短鎖 RNA が司る RNA サイレンシングマシナリー
- 2011 - 小分子 RNA 生合成機序の構造基盤解明
- 2011 - 新規農薬開発を目指した RNA 干渉の基盤研究
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Papers (23):
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Tomohiro Miyoshi, Takaomi Nomura, Koich Takeya, Toshio Uchiumi. The natural bicyclic hexapeptide RA-VII is a novel inhibitor of the eukaryotic translocase eEF2. Biochemical and Biophysical Research Communications. 2022. 615. 88-93
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Takahiro Suzuki, Kosuke Ito, Tomohiro Miyoshi, Ryo Murakami, Toshio Uchiumi. Structural insights into the Switching Off of the Interaction between the Archaeal Ribosomal Stalk and aEF1A by Nucleotide Exchange Factor aEF1B. Journal of molecular biology. 2021. 433. 15. 167046-167046
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Tomohiro Miyoshi, Shogo Oge, Satoshi Nakata, Yuji Ueno, Hidehiko Ukita, Reiko Kousaka, Yuki Miura, Nobuo Yoshinari, Akihiro Yoshida. Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis. Scientific reports. 2021. 11. 1. 11742-11742
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Takumi Hiyoshi, Hisanori Domon, Tomoki Maekawa, Kosuke Nagai, Hikaru Tamura, Naoki Takahashi, Daisuke Yonezawa, Tomohiro Miyoshi, Akihiro Yoshida, Koichi Tabeta, et al. Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis. Microbiology and immunology. 2019. 63. 3-4. 100-110
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Hirotatsu Imai, Takaya Abe, Tomohiro Miyoshi, Shuh-Ichi Nishikawa, Kosuke Ito, Toshio Uchiumi. The ribosomal stalk protein is crucial for the action of the conserved ATPase ABCE1. Nucleic acids research. 2018. 46. 15. 7820-7830
more...
Education (3):
- 2005 - 2008 Niigata University
- 2003 - 2005 Shinshu University
- 1999 - 2003 Shinshu University Faculty of Textile Science and Technology
Work history (4):
- 2022/04 - 現在 Oita University
- 2017 - 2022 Matsumoto Dental University
- 2011 - 2017 Niigata University Institute for Research Promotion Center for Transdisciplinary Research
- 2008 - 2011 Keio University School of Medicine Department of Molecular Biology
Awards (4):
- 2017 - 第16回 インテリジェント・コスモス奨励賞
- 2016 - 第3回 学長賞(新潟大学)
- 2011 - 第27回 井上研究奨励賞
- 2009 - JB論文賞
Association Membership(s) (4):
歯科基礎医学会
, 日本細菌学会
, 日本分子生物学会
, 日本RNA学会
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