Rchr
J-GLOBAL ID：202101009786567077
Update date: Aug. 26, 2024
KAWAGUCHI KOSUKE
カワグチ コウスケ | KAWAGUCHI KOSUKE
Affiliation and department：
Research field (1)：
Pharmaceuticals - health and biochemistry
Research theme for competitive and other funds (4)：
- 2020 - 2023 リソソームからのビタミンB12輸送障害の分子機構解明と治療薬開発への応用
- 2018 - 2021 Characterization of multifunctional roles of TRAF5 in pro-inflammatory cytokine receptor signaling
- 2018 - 2020 Transport mechanism of very long chain fatty acyl-CoA into peroxisomes mediated by peroxisomal ABC protein ABCD1
- 2014 - 2017 ABC protein subfamily D: Mechanisms about subcellular localization and substrate transport, and regulation of cell function
Papers (26)：
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Momoka Imai, Kosuke Kawaguchi, Masashi Morita, Tsuneo Imanaka, Takanori So. Transmembrane helix 6 of ABCD4 is indispensable for cobalamin transport. Journal of inherited metabolic disease. 2024. 47. 2. 366-373
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Kitai K., Kawaguchi K., Tomohiro T., Morita M., So T., Imanaka T. The lysosomal protein ABCD4 can transport vitamin B12 across liposomal membranes in vitro. Journal of Biological Chemistry. 2021. 296. 100654-100654
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Kawaguchi, K., Mukai, E., Watanabe, S., Yamashita, A., Morita, M., So, T., Imanaka, T. Acyl-CoA thioesterase activity of peroxisomal ABC protein ABCD1 is required for the transport of very long-chain acyl-CoA into peroxisomes. Scientific Reports. 2021. 11. 1. 2192-2192
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Morita, M., Toida, A., Horiuchi, Y., Watanabe, S., Sasahara, M., Kawaguchi, K., So, T., Imanaka, T. Generation of an immortalized astrocytic cell line from Abcd1-deficient H-2KbtsA58 mice to facilitate the study of the role of astrocytes in X-linked adrenoleukodystrophy. Heliyon. 2021. 7. 2. e06228
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Morita, M., Kaizawa, T., Yoda, T., Oyama, T., Asakura, R., Matsumoto, S., Nagai, Y., Watanabe, Y., Watanabe, S., Kobayashi, H., et al. Bone marrow transplantation into Abcd1-deficient mice: Distribution of donor derived-cells and biological characterization of the brain of the recipient mice. Journal of Inherited Metabolic Disease. 2020. 44. 3. 718-727
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MISC (17)：
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守田雅志, 浅倉礼奈, 土手陽世, 山田祥大朗, 渡辺志朗, 川口甲介, 宗孝紀. Involvement of peroxisomal membrane protein ABCD1 in lipid droplet formation. 日本薬学会年会要旨集(Web). 2022. 142nd
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川口甲介, 北井克樹, 守田雅志, 今中常雄, 宗孝紀. The transport mechanism of vitamin B12 from the lysosomal lumen to the cytosol by ABC transporter ABCD4. 日本薬学会年会要旨集(Web). 2021. 141st
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川口甲介, 守田雅志, 今中常雄, 宗孝紀. ペルオキシソーム膜ABCタンパク質ABCD1のアシル化部位の解析. 日本生化学会大会(Web). 2021. 94th
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今井桃香, 川口甲介, 守田雅志, 今中常雄, 宗孝紀. リソソーム膜ABCトランスポーターABCD4の基質認識部位の解析. 日本生化学会大会(Web). 2021. 94th
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川口甲介, 北井克樹, 守田雅志, 今中常雄, 宗孝紀. ABCタンパク質を介したリソソームから細胞質へのビタミンB12輸送機構の解析. ビタミン. 2020. 94. 4
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Education (3)：
- 2005 - 2011 Kyoto University Graduate School of Agriculture Division of Applied Life Sciences
- 2003 - 2005 Kyoto University Graduate School of Agriculture Division of Applied Life Sciences
- 1999 - 2003 Kyoto University Faculty of Agriculture
Work history (3)：
- 2019/10 - 現在 University of Toyama
- 2011/10 - 2019/09 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences for Research
- 2011/04 - 2011/09 Kyoto University Graduate School of Agriculture
Association Membership(s) (5)：
日本ビタミン学会
, トランスポーター研究会
, 日本薬学会
, 日本分子生物学会
, 日本生化学会
