Yamamoto Takeshi

ヤマモトタケシ | Yamamoto Takeshi

Affiliation and department：

Research field (1)： Nephrology

Research theme for competitive and other funds (9)：

2024 - 2027 Exploration of aging tubule-inducing factors and their pathophysiology for the development of therapeutic agents for diabetic kidney disease
2024 - 2027 Seeds Search for Preventing AKI in the Elderly Focusing on AKI Vulnerability
2023 - 2026 Development of a novel therapeutic agent targeting TRPC3/6 for refractory and progressive kidney diseases
2023 - 2026 リソソーム-フェロトーシス軸に着目した肥満関連尿細管症の病態解明と治療への応用
2022 - 2024 カルシウムチャネルTRPC3/C6を標的とした腎疾患の治療法確立

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Papers (25)：

Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Satoshi Minami, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, et al. Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4-related amyloidosis. JCI insight. 2024
Sho Matsui, Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, Tomoko Namba-Hamano, Jun Matsuda, Satoshi Minami, Shinsuke Sakai, Hiroaki Yonishi, Jun Nakamura, et al. Empagliflozin protects the kidney by reducing toxic ALB (albumin) exposure and preventing autophagic stagnation in proximal tubules. Autophagy. 2024
Takeshi Yamamoto, Yoshitaka Isaka. Pathological mechanisms of kidney disease in ageing. Nature reviews. Nephrology. 2024
Maeda Shihomi, Sakai Shinsuke, Takabatake Yoshitsugu, Yamamoto Takeshi, Minami Satoshi, Nakamura Jun, Namba-Hamano Tomoko, Takahashi, Atsushi, Matsuda Jun, Yonishi Hiroaki, Matsui Sho, Imai Atsuhiro, Edahiro Ryuya, Yamamoto-Imoto Hitomi, Matsui Isao, Takashima Seiji, Imamura Ryoichi, Nonomura Norio, Yanagita Motoko, Okada Yukinori, Ballabio Andrea, Nakamura Shuhei, Yoshimori Tamotsu, Isaka Yoshitaka. MondoA and AKI and AKI-to-CKD Transition. Journal of the American Society of Nephrology. 2024
Mengying Cui, Koji Yamano, Kenichi Yamamoto, Hitomi Yamamoto-Imoto, Satoshi Minami, Takeshi Yamamoto, Sho Matsui, Tatsuya Kaminishi, Takayuki Shima, Monami Ogura, et al. HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence. Proceedings of the National Academy of Sciences. 2024. 121. 2

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MISC (57)：

Takeshi Yamamoto. Stagnation of autophagy as a driver of kidney disease progression in aging and obesity. 第67回日本腎臓学会学術総会大島賞受賞講演. 2024
山本毅士. 老化と肥満に共通するオートファジー停滞に着目した腎臓病進展の病態解明. 第24回日本抗加齢医学会総会褒章制度受賞者講演. 2024
山本毅士, 中村隼, 猪阪善隆. Age-Related Decline in TFEB Activity in the Kidney Proximal Tubule Affects Systemic Lipid Metabolism and May Cause Amyloidosis. 第24回日本抗加齢医学会総会. 2024
山本毅士. オートファジー停滞に着目した肥満関連尿細管症の病態解明と治療. 第10回JFAS(Japan/Joy of Fatty Acids Secrets/Society). 2024
山本毅士. 老化と肥満に共通するオートファジー停滞に着目した腎臓病進展の病態解明. 最先端循環代謝学の若手研究会(第5回). 2023

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Books (6)：

急性腎障害 Acute kidney injury
医学書院「今日の治療指針」2025年度版 2025
Obesity-related kidney disease
2024
Lipidomics: new insight into pathophysiology and therapeutic targets of kidney disease
2023
オートファジー研究に基づいた糖尿病性腎臓病の治療戦略
国立大学法人大阪大学共創機構研究シーズ集2022(未来社会共創を目指す) 2022
Obesity-Related Tubulopathy
2022

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Professional career (1)：

Medicine (Osaka University)

Awards (3)：

2024/06 - 日本腎臓学会大島賞
2024/05 - 日本抗加齢医学会研究奨励賞
2016/08 - 日本腎臓学会 YIA (Young Investigator Award)

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