Yamamoto Takeshi

ヤマモトタケシ | Yamamoto Takeshi

Affiliation and department：

Research field (1)： Nephrology

Research theme for competitive and other funds (7)：

2023 - 2026 Development of a novel therapeutic agent targeting TRPC3/6 for refractory and progressive kidney diseases
2023 - 2026 リソソーム-フェロトーシス軸に着目した肥満関連尿細管症の病態解明と治療への応用
2022 - 2024 カルシウムチャネルTRPC3/C6を標的とした腎疾患の治療法確立
2022 - 2023 リソソーム内脂肪蓄積に着目した肥満関連尿細管症の病態解明
2021 - 2023 Unraveling the cooperative action of p53 and autophagy against kidney aging

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Papers (22)：

Mengying Cui, Koji Yamano, Kenichi Yamamoto, Hitomi Yamamoto-Imoto, Satoshi Minami, Takeshi Yamamoto, Sho Matsui, Tatsuya Kaminishi, Takayuki Shima, Monami Ogura, et al. HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence. Proceedings of the National Academy of Sciences. 2024. 121. 2
Takeshi Yamamoto, Jun Nakamura, Yoshitsugu Takabatake, Yoshitaka Isaka. Obesity-related proximal tubulopathy: an emerging threat to kidney health. Autophagy Reports. 2023. 2. 1
Takeshi Yamamoto, Yoshitaka Isaka. Dietary Omega-3 Polyunsaturated Fatty Acids and Amelioration of CKD: Possible Cellular Mechanisms. Kidney360. 2023. 4. 12. 1661-1662
Satoshi Minami, Shinsuke Sakai, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Hiroaki Yonishi, Jun Nakamura, Shihomi Maeda, et al. FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity. Autophagy. 2023
Satoshi Minami, Takeshi Yamamoto, Hitomi Yamamoto-Imoto, Yoshitaka Isaka, Maho Hamasaki. Autophagy and kidney aging. Progress in biophysics and molecular biology. 2023. 179. 10-15

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MISC (56)：

山本毅士. オートファジー停滞に着目した肥満関連尿細管症の病態解明と治療. 第10回JFAS(Japan/Joy of Fatty Acids Secrets/Society). 2024
山本毅士. 老化と肥満に共通するオートファジー停滞に着目した腎臓病進展の病態解明. 最先端循環代謝学の若手研究会(第5回). 2023
山本毅士. エンパグリフロジンは近位尿細管における脂肪酸毒性とオートファジー負担を軽減し腎保護に働く. 第44回日本肥満学会・第41回日本肥満症治療学会学術集会. 2023
山本毅士. オートファジーと腎臓の老化. 第3回日本オートファジーコンソーシアムシンポジウム. 2023
山本毅士, 猪阪善隆. 腎臓の老化とオートファジー. 第53回日本腎臓学会東部学術総会シンポジウム2 老化を司る腎臓の秘密. 2023

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Books (4)：

Lipidomics: new insight into pathophysiology and therapeutic targets of kidney disease
2023
オートファジー研究に基づいた糖尿病性腎臓病の治療戦略
国立大学法人大阪大学共創機構研究シーズ集2022(未来社会共創を目指す) 2022
Obesity-Related Tubulopathy
2022
Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule
2016

Professional career (1)：

Awards (2)：

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