Sawamoto Kazuki

サワモトカズキ | Sawamoto Kazuki

Research field (3)： Metabolism and endocrinology , Molecular biology , Clinical pharmacy

Research keywords (4)： Clinical pharmacy , Bone targeting , Life-style related disease , Gene therapy

Research theme for competitive and other funds (9)：

2022 - 2025 Role of Nrf2 in glucose and lipid metabolism
2021 - 2022 レドックス調節因子Nrf2が肝臓における肥満特異的な代謝制御に与える影響の解明
2021 - 2022 レドックス調節因子の発現制御に基づく肥満・糖尿病に対する新規予防・治療法の創出
2021 - 2022 Development of new Nrf2-activating therapy for obesity and diabetes
2020 - 2022 Development of a bone-targeted gene therapy using an engineered adeno-associated virus capsid

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Papers (48)：

Suratsawadee Promsuwan, Kazuki Sawamoto, Liang Xu, Mayumi Nagashimada, Naoto Nagata, Yumi Takiyama. A natural Nrf2 activator glucoraphanin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation. Diabetology International. 2023
Matthew Piechnik, Paige C Amendum, Kazuki Sawamoto, Molly Stapleton, Shaukat Khan, Nidhi Fnu, Victor Álvarez, Angelica Maria Herreño Pachon, Olivier Danos, Joseph T Bruder, et al. Sex Difference Leads to Differential Gene Expression Patterns and Therapeutic Efficacy in Mucopolysaccharidosis IVA Murine Model Receiving AAV8 Gene Therapy. International journal of molecular sciences. 2022. 23. 20
Takao Takiyama, Toshihiro Sera, Masanori Nakamura, Masato Hoshino, Kentaro Uesugi, Shin-Ichi Horike, Makiko Meguro-Horike, Ryoichi Bessho, Yuri Takiyama, Hiroya Kitsunai, et al. A maternal high-fat diet induces fetal origins of NASH-HCC in mice. Scientific reports. 2022. 12. 1. 13136-13136
Mayumi Nagashimada, Kazuki Sawamoto, Yinhua Ni, Hironori Kitade, Naoto Nagata, Liang Xu, Masuko Kobori, Naofumi Mukaida, Tatsuya Yamashita, Shuichi Kaneko, et al. CX3CL1-CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice. Endocrinology. 2021. 162. 6
Kazuki Sawamoto, J Víctor Álvarez, Angélica María Herreño, Francisco J Otero-Espinar, Maria L Couce, Carlos J Alméciga-Díaz, Shunji Tomatsu. Bone-Specific Drug Delivery for Osteoporosis and Rare Skeletal Disorders. Current osteoporosis reports. 2020. 18. 5. 515-525

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MISC (49)：

別所瞭一, 滝山貴央, Promsuwan Suratsawadee, 宿田夕季, 橘内博哉, 澤本一樹, 竹田安孝, 坂上英充, 滝山由美. Nrf2活性化剤によるTFAM活性化とSTING抑制作用. 糖尿病. 2021. 64. Suppl.1. I-3
澤本一樹, 長田直人, Promsuwan Suratsawadee, Xu Liang. グルコラファニンによる肥満・インスリン抵抗性に対する治療効果. 糖尿病. 2020. 63. Suppl.1. S-311
永島田まゆみ, 倪銀華, 澤本一樹, 太田嗣人. 肥満により減弱するFractalkine-CX3CR1シグナルの回復は,インスリン抵抗性を改善する. 糖尿病. 2019. 62. Suppl.1. S-196
永島田まゆみ, 倪銀華, 澤本一樹, 太田嗣人. Fractalkine-CX3CR1シグナルの欠損は、脂肪組織マクロファージをM1優位にシフトさせ、インスリン抵抗性を増悪させる. 糖尿病. 2018. 61. Suppl.1. S-364
永島田まゆみ, 倪銀華, 澤本一樹, 太田嗣人. Fractalkine-CX3CR1シグナルの欠損は、肥満によるインスリン抵抗性を増悪させる. 糖尿病. 2017. 60. Suppl.1. S-459

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Patents (2)：

TREATMENT OF MUCOPOLYSACCHARIDOSIS IVA
AN AGENT, A DEVICE AND A BLOOD-CIRCULATION SYSTEM FOR TREATING LYSOSOMAL STORAGE DISEASES, AND A METHOD FOR TREATING LYSOSOMAL STORAGE DISEASES

Books (1)：

Mucopolysaccharidoses update (2 volume set)
Nova Science Publishers 2018 ISBN:9781536139860

Education (3)：

2011 - 2014 Kanazawa University Graduate School of Natural Science and Technology
2009 - 2011 Kanazawa University Graduate School of Natural Science and Technology Division of Phamaceutical Sciences
2005 - 2009 Kanazawa University Faculty of Pharmaceutical Sciences

Professional career (1)：

Ph.D. (Kanazawa University)

Work history (4)：

2021/10 - 2023/03 Asahikawa Medical University
2019/10 - 2021/09 Asahikawa Medical University Prevention and Therapy of Diabetes and Life style Related Diseases Laboratory Assistant Professor
2014/11 - 2019/09 Nemours/Alfred l. duPont Hospital for Children Biomedical Research Post-doctoral Research Fellow
2011/04 - 2014/09 University Hospital, Kanazawa University Department of Hospital Pharmacy Assistant Professor

Awards (2)：

2016/06 - 医療薬学フォーラム2016 優秀ポスター賞タクロリムスの静脈内から経口投与への切り替え時における体格指数の体内動態変動に与える影響
2012/07 - - -

Association Membership(s) (2)：

日本分子生物学会 , 日本薬学会

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