Rchr
J-GLOBAL ID：202101010952811460
Update date: Jul. 01, 2024
Mikame Yu
ミカメ ユウ | Mikame Yu
Affiliation and department：
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (3)：
Design and development of functional small molecule
, Design and development of functional oligonucleotides
, Oligonucleotide Therapeutics
Research theme for competitive and other funds (5)：
- 2024 - 2025 がん細胞選択的な薬効を示す新規ソラレン導入型核酸の開発
- 2022 - 2025 Development of novel psoralen conjugated triplex forming oligonucleotides and its application to photo genome editing technology
- 2023 - 2024 光機能性核酸を用いた新規遺伝子制御法
- 2023 - 2024 プロウイルス遺伝子を標的とした新規光駆動性核酸の開発
- 2022 - 2023 Development of photoreactive oligonucleotide targeting provirus genome
Papers (10)：
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Yu Mikame, Nagisa Maekawa, Soichiro Kimura, Juki Nakao, Asako Yamayoshi. Modular Synthesis of Methyl-Substituted Novel Psoralen N-Hydroxysuccinimide Esters and Evaluation of DNA Photo-Crosslinking Properties of the Corresponding Triplex-Forming Oligonucleotide Conjugates. Synlett. 2023
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Shota Oyama, Mao Tomita, Moeka Hata, Yu Mikame, Tsuyoshi Yamamoto, Eishi Ashihara, Asako Yamayoshi. Exosome-Hijacking Drug Delivery System with Branched Arginine Linker Effectively Deliver Antisense Oligonucleotides into Lung Adenocarcinoma Cells. Chemical & pharmaceutical bulletin. 2023. 71. 11. 819-823
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Yu Mikame, Asako Yamayoshi. Recent Advancements in Development and Therapeutic Applications of Genome-Targeting Triplex-Forming Oligonucleotides and Peptide Nucleic Acids. Pharmaceutics. 2023. 15. 10
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Yu Mikame, Honoka Eshima, Haruki Toyama, Juki Nakao, Misaki Matsuo, Tsuyoshi Yamamoto, Yoshiyuki Hari, Jun A Komano, Asako Yamayoshi. Development and Crosslinking Properties of Psoralen-Conjugated Triplex-Forming Oligonucleotides as Antigene Tools Targeting Genome DNA. ChemMedChem. 2023. e202300348
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Juki Nakao, Yu Mikame, Honoka Eshima, Tsuyoshi Yamamoto, Chikara Dohno, Takehiko Wada, Asako Yamayoshi. Unique Crosslinking Properties of Psoralen-conjugated Oligonucleotides developed by Novel Psoralen N-Hydroxysuccinimide Esters. Chembiochem : a European journal of chemical biology. 2023. 24. 15. e202200789
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Patents (1)：
Books (2)：
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CLINICAL NEUROSCIENCE Vol.41 No.5 「核酸医薬と神経疾患」
2023
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Drug Delivery System
2023
Lectures and oral presentations (20)：
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ゲノム編集を可能とする新規光架橋性人工核酸の開発
(日本薬学会第144年会 2024)
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新規ソラレン導入三重鎖形成核酸によるヒト乳がん細胞への選択的な細胞死誘導効果
(日本化学会第104春期年会 2024)
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糖部架橋型核酸を基盤とした新規ソラレン導入型三重鎖形成核酸の開発
(日本核酸医薬学会 第8回年会 2023)
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Triplex stabilizing effect and photo-crosslinking ability of a novel psoralen-conjugated triplex-forming oligonucleotide
(2023)
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新規ソラレン導入型三重鎖形成核酸の開発と標的ゲノム配列の拡張性評価
(日本化学会第103春季年会 2023)
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Education (3)：
- 2016 - 2019 Tokyo University of Agriculture and Technology Graduate School of Engineering Department of Biotechnology and Life Science
- 2014 - 2016 Tokyo University of Agriculture and Technology Graduate School of Engineering Department of Biotechnology and Life Science
- 2010 - 2014 Tokyo University of Agriculture and Technology Faculty of Engineering Department of Biotechnology and Life Science
Professional career (1)：
- Doctor (Engineering) (Tokyo University of Agriculture and Technology)
Work history (3)：
- 2021/04 - 現在 Nagasaki University Graduate School of Biomedical Sciences
- 2019/04 - 2021/03 Harvard University Chemistry and Chemical Biology building Research scholar
- 2016/04 - 2019/03 RIKEN Cluster for Pioneering Research Junior Research Associate
Association Membership(s) (4)：
Nucleic Acids Therapeutics Society of Japan
, The Japan society of nucleic acids chemistry
, The pharmaceutical society of Japan
, The chemical society of Japan
