Matsushima Saki

Affiliation and department：

Research field (2)： Virology , Molecular biology

Research keywords (2)：アデノウイルスベクター , 遺伝子治療

Research theme for competitive and other funds (8)：

2021 - 2026 BBB通過型GALC発現AAVベクターはクラッベ病マウスの寿命延長効果を持つか
2022 - 2026 Pompe病の根治を目指した新規遺伝子治療法の開発研究
2021 - 2024 ヒト型受容体介在性トランスサイトーシスを利用したライソゾーム病遺伝子治療法の開発
2015 - 2018 Search for new potential drug targets for Hepatitis B virus genome replication based on chemical biology
2015 - 2017 ウイルスベクターによる高感度HBV複製検出系を用いたcccDNA生成機序の解析

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Papers (23)：

Sayaka Nagamoto, Miyuki Agawa, Emi Tsuchitani, Kazunori Akimoto, Saki Kondo Matsushima, Yumi Kanegae. Short term but highly efficient Cas9 expression mediated by excisional system using adenovirus vector and Cre. Scientific reports. 2021. 11. 1. 24369-24369
Manabu Yamasaki, Norie Matsuda, Kazuaki Matoba, Saki Kondo, Yumi Kanegae, Izumu Saito, Akio Nomoto. Acetophenone 4-nitrophenylhydrazone inhibits Hepatitis B virus replication by modulating capsid assembly. Virus research. 2021. 306. 198565-198565
角皆季樹, 大橋十也, 嶋田洋太, 樋口孝, 木村文香, 松島小貴, 渡部文子, 小林博司. 造血幹細胞を標的としたレンチウイルスベクターを用いたGM1ガングリオシドーシスの遺伝子治療法の開発. 東京慈恵会医科大学雑誌. 2021. 136. 6. 136-137
Malgorzata Gozdecka, Eshwar Meduri, Milena Mazan, Konstantinos Tzelepis, Monika Dudek, Andrew J Knights, Mercedes Pardo, Lu Yu, Jyoti S Choudhary, Emmanouil Metzakopian, et al. UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs. Nature genetics. 2018. 50. 6. 883-894
Mariko Suzuki, Saki Kondo, Manabu Yamasaki, Norie Matsuda, Akio Nomoto, Tetsuro Suzuki, Izumu Saito, Yumi Kanegae. Efficient genome replication of hepatitis B virus using adenovirus vector: a compact pregenomic RNA-expression unit. Scientific reports. 2017. 7. 41851-41851

ｍore...

MISC (2)：

Saki Kondo, Yumi Kanegae, Nic Jones, Izumu Saito. A role of microRNAs for sensitization to cisplatin in ovarian cancer cell lines. HUMAN GENE THERAPY. 2012. 23. 10. A96-A96
Saki Kondo, Miho Terashima, Pei Zheng, Yumi Kanegae, Izumu Saito. Construction of "Humanized" FLP Recombinases Aiming for Efficient Generation of Helper-Dependent Adenovirus Vector. MOLECULAR THERAPY. 2009. 17. S45-S45

Lectures and oral presentations (3)：

Gene therapy for GM1 gangliosidosis mediated by AAV vector carrying BBB-penetrable enzyme
(American Society of Gene and Cell Therapy 2023)
Gene therapy for GM1 gangliosidosis mediated by AAV vector carrying BBB-penetrable enzyme
(2022)
Gene therapy for GM1 gangliosidosis mediated by AAV vector carrying BBB-penetrable enzyme
(2022)

Education (2)：

Professional career (1)：

Work history (5)：

Association Membership(s) (2)：

日本先天代謝異常学会 , 日本遺伝子細胞治療学会

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