Goto Masanori

ゴトウマサノリ | Goto Masanori

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Experimental pathology

Research keywords (7)： gastric cancer , liver regeneration , cholangiocarcinoma , base excision repair , hepatocellular carcinoma , Myc , DNA adduct

Research theme for competitive and other funds (6)：

2019 - 2023 Mechanisms determining the wide spectrum of hepatocytic tumors
2021 - 2022 The effect of overexpression of Myc family genes on the progression and metastasis of hepatocellular carcinoma
2021 - 2022 Analysis of the effect of decreased expression of proline-metabolizing enzyme PRODH in hepatocellular carcinoma
2019 - 2020 Effect of non-alcoholic steatohepatitis (NASH) on liver carcinogenesis in mice that introduced oncogene
2019 - 2019 非アルコール性脂肪肝炎の細胞老化と肝発癌への影響:Myc機能阻害による制御の試み

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Papers (39)：

田中宏樹, 堀岡希衣, 後藤正憲, 藤井裕美子, 上小倉佑機, 小川勝洋, 西川祐司. Tumor-educated plateletsの蛋白質合成能の増強による肝発がん促進. 日本病理学会会誌. 2023. 112. 1. 259-259
Masanori Goto, Takako Ooshio, Masahiro Yamamoto, Hiroki Tanaka, Yumiko Fujii, Lingtong Meng, Yuki Kamikokura, Yoko Okada, Yuji Nishikawa. High levels of Myc expression are required for the robust proliferation of hepatocytes, but not for the sustained weak proliferation. Biochimica et biophysica acta. Molecular basis of disease. 2023. 1869. 4. 166644-166644
Yuji Nishikawa, Yasuhiro Matsuo, Ryosuke Watanabe, Mitsuyuki Miyazato, Mikiko Matsuo, Yasuharu Nagahama, Hiroki Tanaka, Takako Ooshio, Masanori Goto, Yoko Okada, et al. Hepatocyte-specific damage in acute toxicity of sodium ferrous citrate: Presentation of a human autopsy case and experimental results in mice. Toxicology reports. 2023. 10. 669-679
Hiroki Tanaka, Kie Horioka, Takumu Hasebe, Koji Sawada, Shunsuke Nakajima, Hiroaki Konishi, Shotaro Isozaki, Masanori Goto, Yumiko Fujii, Yuki Kamikokura, et al. Treatment of hepatocellular carcinoma with autologous platelets encapsulating sorafenib or lenvatinib: A novel therapy exploiting tumor-platelet interactions. International journal of cancer. 2021. 150. 10. 1640-1653
Lingtong Meng, Masanori Goto, Hiroki Tanaka, Yuki Kamikokura, Yumiko Fujii, Yoko Okada, Hiroyuki Furukawa, Yuji Nishikawa. Decreased Portal Circulation Augments Fibrosis and Ductular Reaction in Nonalcoholic Fatty Liver Disease in Mice. The American journal of pathology. 2021. 191. 9. 1580-1591

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MISC (24)：

田中宏樹, 堀岡希衣, 後藤正憲, 人見淳一, 藤井裕美子, 上小倉佑機, 孟玲童, 小川勝洋, 西川祐司. 自己血小板を利用したドラッグデリバリーシステム肝癌・血小板相互作用を利用した新たな治療戦略. 日本病理学会会誌. 2021. 110. 1. 224-224
田中宏樹, 堀岡希衣, 後藤正憲, 人見淳一, 藤井裕美子, 上小倉佑機, 孟玲童, 小川勝洋, 西川祐司. 自己血小板を利用したドラッグデリバリーシステム肝癌・血小板相互作用を利用した新たな治療戦略. 日本病理学会会誌. 2021. 110. 1. 224-224
後藤正憲, 大塩貴子, 山本雅大, 人見淳一, 藤井裕美子, 田中宏樹, 上小倉佑機, 孟玲童, 岡田陽子, 西川祐司. Myc非依存性の肝細胞再生性増殖におけるプロリン代謝の意義. 日本癌学会総会記事. 2020. 79回. OJ13-4
田中宏樹, 堀岡希衣, 後藤正憲, 人見淳一, 藤井裕美子, 上小倉佑機, 孟玲童, 小川勝洋, 西川祐司. 腫瘍・血小板相互作用を利用した肝癌に対する新規治療法. 日本癌学会総会記事. 2020. 79回. PE16-3
新村和也, 加藤寿美, 川西祐一, 後藤正憲, TAO Hong, 吉村克弘, 中村悟己, 三澤清, 椙村春彦. NTHL1関連ポリポーシス(NAP)原因遺伝子であるNTHL1のvariant型のDNAグリコシラーゼ能および変異抑制能評価. 日本病理学会会誌. 2019. 108. 1. 309-310

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Lectures and oral presentations (11)：

Differential effects of Myc and N-Myc on the lung metastatic potential of liver tumors induced in mice
(2023)
プロリン代謝酵素proline dehydrogenase発現亢進によるマウス肝腫瘍の自然破裂頻度の増加
(肝細胞研究会 2023)
Mouse liver tumors induced by activated Notch pathway and Myc: Differential effects of Myc and N-Myc
(2023)
Association between an oncogene Myc and the proline metabolic enzyme, PRODH, in hepatocellular carcinoma.
(The Japanese Society for the Reserch of Hepatic Cells 2022)
Effects of Myc and Mycn on mouse cholangiocarcinoma phenotype induced by activated AKT and YAP
(Annual Meeting og the Japanese Society of Pathology 2022)

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Education (1)：

2006 - 2010 Hamamatsu University School of Medicine

Work history (3)：

2016/05 - 現在 Asahikawa Medical University Department of pathology Assistant Professor
2012/10 - 2016/04 National Cancer Center
2010/04 - 2012/10 Hamamatsu University School of Medicine Department of tumor pathology postdoctoral fellow

Association Membership(s) (4)：

日本病理学会 , 肝細胞研究会 , 日本癌学会 , 環境変異原学会

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