2019 - 2022 Identification of novel ER stress relieving drugs using a high-content microscope and application to therapeutic development
2018 - 2021 The expression of G protein-coupled receptor 3 modulates presynaptic function in differentiated PC12 cells
2016 - 2019 Identification and application of novel chaperone mechanism using C-terminal deficient serotonin transporter as a sensor
2016 - 2019 Screening and application of drugs that facilitate membrane trafficking in order to overcome ER stress-related diseases
2015 - 2018 Functional analysis of G-protein coupled receptor 3 in the formation of neuronal polarity and future application of central nervous system disorder
2015 - 2018 Elucidation of mechanism on neuronal cell death and development of hemodiagnosis in ischemic stroke
2013 - 2016 Screening and development of drugs that can contribute to the treatment of intractable neuropsychiatric disease by regulating membrane trafficking and lysosomal degradation.
2012 - 2015 Functional analysis of G-protein coupled receptor 3 for future applications of novel stroke therapy utilizing neuronal stem cell transplantation
2012 - 2014 Development of screening methods to find novel therapeutic drugs for neurodegenerative disease using fluorescence-based probe and high-content microscope.
2010 - 2012 Development of therapeutic strategy for intractable neuropsychiatric disease using chemical chaperones
2009 - 2011 Functional analysis of G-protein coupled receptor 6 following brain ischemia
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Papers (51)：
Kana Harada, Ryoma Sho, Hiromiki Takakura, Eri Yokoyama, Reika Koyama, Yuka Yamamoto, Naoko Adachi, Shigeru Tanaka, Izumi Hide, Norio Sakai. S-Palmitoylation of the serotonin transporter promotes its cell surface expression and serotonin uptake. Biochemical and biophysical research communications. 2023. 662. 58-65
Shiraki, Hiroko, Tanaka, Shigeru, Guo, Yun, Harada, Kana, Hide, Izumi, Yasuda, Tomoharu, Sakai, Norio. Potential role of inducible GPR3 expression under stimulated T cell conditions. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2022. 148. 3. 307-314
Tanaka, Shigeru, Shimada, Naoto, Shiraki, Hiroko, Miyagi, Tatsuhiro, Harada, Kana, Hide, Izumi, Sakai, Norio. GPR3 accelerates neurite outgrowth and neuronal polarity formation via PI3 kinase-mediating signaling pathway in cultured primary neurons. MOLECULAR AND CELLULAR NEUROSCIENCE. 2022. 118
Hirakawa, Haruki, Taguchi, Kei, Murakawa, Seiya, Asano, Masaya, Noguchi, Soma, Kikkawa, Satoshi, Harada, Kana, Adachi, Naoko, Ueyama, Takehiko, Hide, Izumi, et al. Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2022. 148. 1. 187-195
Zemgulyte, Gintare, Tanaka, Shigeru, Hide, Izumi, Sakai, Norio, Pampuscenko, Katryna, Borutaite, Vilmante, Rastenyte, Daiva. Evaluation of the Effectiveness of Post-Stroke Metformin Treatment Using Permanent Middle Cerebral Artery Occlusion in Rats. PHARMACEUTICALS. 2021. 14. 4
Shigeru Tanaka, Tatsuhiro Miyagi, Izumi Hide, Toshihiko Shirafuji, E. Antonio Chiocca, Norio Sakai. The expression of GPR3 protects cerebellar granular neurons from various apoptotic stimuli. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 113P-113P
Izumi Hide, Mayumi Kamigaki, Yuhki Yanase, Takahiro Seki, Shigeru Tanaka, Toshihiko Shirafuji, Michihiro Hide, Norio Sakai. Modulation of microglial function by TLR4-mediated adenosine A2a receptor activation. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 211P-211P
Tatsuhiro Miyagi, Shigeru Tanaka, Izumi Hide, Toshihiko Shirafuji, Norio Sakai. The subcellular localization and local function of Gs-linked receptor GPR3 in neuronal cells. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 144P-144P
Shigeru Tanaka, Tatsuhiro Miyagi, Izumi Hide, Takahiro Seki, Norio Sakai. Gbetagamma mediated signaling pathway is partially involved in the neurite outgrowth via GPR3. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 179P-179P
Mayumi Kamigaki, Izumi Hide, Yuhki Yanase, Kana Harada, Takahiro Seki, Shigeru Tanaka, Michihiro Hide, Norio Sakai. Drastic expression of granulocyte macrophage colony-stimulating factor (GM-CSF) by Toll-like receptor 4-activated surviving microglia. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 216P-216P
The Molecular Biology Society of Japan
, The Japan Academy of Neurosonology
, 日本神経学会
, 日本内科学会
, 日本脳循環代謝学会
, 日本脳卒中学会
, 日本神経化学学会
, Society for Neuroscience
, 日本神経科学学会
, 日本薬理学会
