Rchr
J-GLOBAL ID：202101012172901168
Update date: Feb. 01, 2025
OUHARA KAZUHISA
オウハラ カズヒサ | OUHARA KAZUHISA
Affiliation and department：
Research field (3)：
Immunology
, Bacteriology
, Conservative dentistry and endodontics
Research keywords (3)：
Porphyromonas gingivalis
, rheumatoid arthritis
, Periodontal Disease
Research theme for competitive and other funds (17)：
- 2023 - 2026 Development of a rapid diagnostic kit for oral bacteria associated with systemic disease using saliva
- 2022 - 2025 侵襲性歯周炎の新規責任遺伝子の同定と病態解析
- 2022 - 2025 Elucidation of the mechanism of periodontal tissue destruction by ACPA derived from patients with rheumatoid arthritis and periodontopathogenic bacteria-related proteins
- 2021 - 2024 Cnm陽性う蝕原因細菌のPRIPを介した脳出血増悪機序解明による健康寿命の延伸
- 2021 - 2024 Comprehensive study on the effects of periodontal pathogen on the pathophysiology of atrial fibrillation
- 2021 - 2024 Elucidation of the pathological mechanism of rheumatoid arthritis induced by N-linked glycans in the ACPA variable region
- 2020 - 2023 Establishment of rapid detection method for oral bacterial genes associated with systemic diseases
- 2022 - 2023 Epidemiological study on the safety and effectiveness of periodontal disease treatment in patients taking anticoagulants
- 2019 - 2022 Development of inhibitors of osteoclast differentiation with an anti-citrullinated protein monoclonal antibody
- 2018 - 2021 The induced RNA-binding protein, HuR targets of IL-6 mRNA and enhances its stabilization in periodontitis
- 2015 - 2018 The bidirectional effect of Leucine-rich alpha-2-glycoprotein 1 (LRG1) in rheumatoid arthritis and periodontitis
- 2015 - 2017 The basic research for the prevention of periodontitis induced bacterimia by using probiotics
- 2013 - 2016 Elucidate the mechanism of aggravation of endodontic disease on diabetic patients
- 2013 - 2015 The effect of PAD derived from periodontopathogenic bacteria in rheumatoid arthritis
- 2012 - 2015 Induction of cementoblastic differentiation from mesenchymal stem cells and cementogenesis on dentin surface
- 2010 - 2012 The analysis and application for periodontal treatment of FcRn which is tha passive IgG transporter in epithelial cells
- 2009 - 2010 上皮細胞が産生するIgG能動輸送タンパク質FcRnによる歯周炎治療法の開発
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Papers (112)：
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Shoko Kono, Shinya Sasaki, Shinji Matsuda, Katsuhiro Takeda, Tomoyuki Iwata, Kazuhisa Ouhara, Mikihito Kajiya, Hidemi Kurihara, Noriyoshi Mizuno. Brain-derived neurotrophic factor promotes bone regeneration in a canine model of peri-implantitis. International journal of implant dentistry. 2024. 10. 1. 59-59
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Yurika Ninomiya, Shinji Matsuda, Shigeki Suzuki, Shizu Hirata-Tsuchiya, Tomoya Ueda, Fuminori Nakashima, Keisuke Yasuda, Shogo Shimada, Takumi Memida, Tetsuya Yoshimoto, et al. Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis. BMC Oral Health. 2024. 24. 1
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Tomoki Kawayanagi, Miki Kawada-Matsuo, Toru Takeshita, Mi Nguyen-Tra Le, Mikari Asakawa, Yo Sugawara, Chika Arai, Kazuhisa Ouhara, Hiromi Nishi, Noriyoshi Mizuno, et al. The oral cavity is a potential reservoir of gram-negative antimicrobial-resistant bacteria, which are correlated with ageing and the number of teeth. Heliyon. 2024. 10. 21. e39827
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Kana Oue, Yosuke Yamawaki, Kazuhisa Ouhara, Eiji Imado, Tetsuya Tamura, Mitsuru Doi, Yoshitaka Shimizu, Mitsuhiro Yoshida, Noriyoshi Mizuno, Norimitsu Morioka, et al. Oral administration of Porphyromonas gingivalis to mice with diet-induced obesity impairs cognitive function associated with microglial activation in the brain. Journal of Oral Microbiology. 2024. 16. 1
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Shinji Matsuda, Tomoya Ueda, Fuminori Nakashima, Yurika Ninomiya, Keisuke Yasuda, Shinya Sasaki, Yuta Hamamoto, Tomoyuki Iwata, Kazuhisa Ouhara, Naoki Mihara, et al. Predictive factors of periodontal regeneration outcomes using rhFGF-2: A case-control study. Journal of Periodontal Research. 2024
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MISC (7)：
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森本慎, 加治屋幹人, 堀越励, 吉井寛毅, 吉野舞, 應原一久, 松田真司, 岩田倫幸, 佐々木慎也, 濱本結太, et al. ボーンカラーを持った軟骨原基様構造物は早期に軟骨内骨化を介した骨再生を引き起こす. 日本歯周病学会会誌(Web). 2023. 65
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目見田 匠, 松田 真司, 鈴木 茂樹, 加治屋 幹人, 應原 一久, 岡信 愛, 畑野 紗希, 古玉 大祐, 柴 秀樹, 山田 聡, et al. 全身性強皮症患者に出現した多発性歯根外部吸収のメカニズム解明. 日本歯周病学会会誌. 2021. 63. 秋季特別. 122-122
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目見田 匠, 松田 真司, 鈴木 茂樹, 加治屋 幹人, 應原 一久, 岡信 愛, 畑野 紗希, 古玉 大祐, 柴 秀樹, 山田 聡, et al. 全身性強皮症患者に出現した多発性歯根外部吸収のメカニズム解明. 日本歯周病学会会誌. 2021. 63. 秋季特別. 122-122
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SHIBA Hideki, KAJIYA Mikihito, OUHARA Kazuhisa, FUJITA Tsuyoshi, MORIMOTO Mayumi, TAKEDA Katsuhiro, MIZUNO Noriyoshi, KAWAGUCHI Hiroyuki, KURIHARA Hidemi. Effects of LL37 on expressions of inflammatory cytokines and migration in human pulp cells. 2006. 49. 50-50
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應原 一久, 小松澤 均, 落合 恭子, 西 裕美, 栗原 英見, 菅井 基行. MRSAはMSSAに比べヒト抗菌ペプチドに対して感受性が低いか?. 日本細菌学雑誌. 2004. 59. 1. 145-145
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Books (2)：
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歯周病患者における再生療法のガイドライン2023
2023
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ザ・ペリオドントロジー 第4版
2023
Lectures and oral presentations (44)：
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Rheumatoid arthritis affected by periodontogenic bacterium, Porphyromonas gingivalis and SDGs
(Th 76th Annual Meeting of Japanese Stomatological Sciety 2022)
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The pathology of periodontal disease and its effect on systemic diseases
(2022)
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The mechanism of ACPA as a pathogenic factor in the progression of rheumatoid arthritis
(14th Young Researchers in Advanced Rheumatology (YRAR) 2019)
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The mechanism of induction of rheumatois arthritis by ACPA
(Osteoimmunology Seminor 2018 Second Half 2018)
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全身性強皮症に出現した歯の骨様組織置換性吸収の症例報告
(第29回日本リウマチ学会中国・四国支部学術集会 2018)
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Awards (5)：
- 2019/10/25 - 日本歯周病学会理事長 第19回日本歯周病学会 学術賞 歯周病原細菌に対する歯周組織局所の免疫応答が及ぼす全身疾患への影響に関する研究
- 2019/10 - NPO法人 日本歯周病学会 日本歯周病学会学術賞 歯周病原細菌に対する歯周組織局所の免疫応答が及ぼす全身疾患への影響に関する研究
- 2019/05/24 - 日本歯周病学会理事長 2018年度 日本歯周病学会 奨励賞 Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration
- 2018/11/17 - Japanese Association for Dental Research President The 66th Japanese Association for Dental Research / Joseph Lister Award 2018 First prize
- 2015/11/05 - 日本歯科医学会 優秀発表賞 歯周病原細菌Porphyromonas gingivalisが産生するメチルメルカプタン抑制作用を有する漢方の臨床応用
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