OUHARA KAZUHISA

オウハラカズヒサ | OUHARA KAZUHISA

Affiliation and department：

Research field (3)： Immunology , Bacteriology , Conservative dentistry and endodontics

Research keywords (3)： Porphyromonas gingivalis , rheumatoid arthritis , Periodontal Disease

Research theme for competitive and other funds (17)：

2023 - 2026 Development of a rapid diagnostic kit for oral bacteria associated with systemic disease using saliva
2022 - 2025 侵襲性歯周炎の新規責任遺伝子の同定と病態解析
2022 - 2025 Elucidation of the mechanism of periodontal tissue destruction by ACPA derived from patients with rheumatoid arthritis and periodontopathogenic bacteria-related proteins
2021 - 2024 Cnm陽性う蝕原因細菌のPRIPを介した脳出血増悪機序解明による健康寿命の延伸
2021 - 2024 Comprehensive study on the effects of periodontal pathogen on the pathophysiology of atrial fibrillation

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Papers (99)：

Mizuho Kittaka, Noriyoshi Mizuno, Hiroyuki Morino, Tetsuya Yoshimoto, Tianli Zhu, Sheng Liu, Ziyi Wang, Kotoe Mayahara, Kyohei Iio, Kaori Kondo, et al. Loss-of-function OGFRL1 variants identified in autosomal recessive cherubism families. JBMR plus. 2024. 8. 6. ziae050
Kazuhisa Ouhara, Tasuku Takemura, Yuri Taniguchi, Ryousuke Fujimori, Tetsuya Tamura, Yuki Akane, Shinji Matsuda, Yuta Hamamoto, Tomoaki Shintani, Mikihito Kajiya, et al. Leucine-rich alpha-2-glycoprotein 1 affects bone destruction via IL-6 in mouse periodontitis model. Oral diseases. 2024
Shunsuke Miyauchi, Kazuhisa Ouhara, Tomoaki Shintani, Takehito Tokuyama, Yousaku Okubo, Sho Okamura, Shogo Miyamoto, Naoto Oguri, Yukimi Uotani, Tasuku Takemura, et al. Periodontal Treatment During the Blanking Period Improves the Outcome of Atrial Fibrillation Ablation. Journal of the American Heart Association. 2024. 13. 8. e033740
Reika Hirata, Tomoyuki Iwata, Tsuyoshi Fujita, Takayoshi Nagahara, Shinji Matsuda, Shinya Sasaki, Yuri Taniguchi, Yuta Hamamoto, Kazuhisa Ouhara, Yasusei Kudo, et al. Periostin regulates integrin expression in gingival epithelial cells. Journal of oral biosciences. 2023
Mai Yoshino, Mikihito Kajiya, Hiroki Yoshii, Shin Morimoto, Susumu Horikoshi, Misako Tari, Tomoyuki Iwata, Kazuhisa Ouhara, Toshinori Ando, Tetsuya Yoshimoto, et al. Distinctive Biological Properties between Mesenchymal Stem Cell Spheroids and Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes in 3D Culture Systems. Applied Sciences. 2023. 13. 23. 12790-12790

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MISC (6)：

目見田匠, 松田真司, 鈴木茂樹, 加治屋幹人, 應原一久, 岡信愛, 畑野紗希, 古玉大祐, 柴秀樹, 山田聡, et al. 全身性強皮症患者に出現した多発性歯根外部吸収のメカニズム解明. 日本歯周病学会会誌. 2021. 63. 秋季特別. 122-122
目見田匠, 松田真司, 鈴木茂樹, 加治屋幹人, 應原一久, 岡信愛, 畑野紗希, 古玉大祐, 柴秀樹, 山田聡, et al. 全身性強皮症患者に出現した多発性歯根外部吸収のメカニズム解明. 日本歯周病学会会誌. 2021. 63. 秋季特別. 122-122
SHIBA Hideki, KAJIYA Mikihito, OUHARA Kazuhisa, FUJITA Tsuyoshi, MORIMOTO Mayumi, TAKEDA Katsuhiro, MIZUNO Noriyoshi, KAWAGUCHI Hiroyuki, KURIHARA Hidemi. Effects of LL37 on expressions of inflammatory cytokines and migration in human pulp cells. 2006. 49. 50-50
應原一久, 小松澤均, 落合恭子, 西裕美, 栗原英見, 菅井基行. MRSAはMSSAに比べヒト抗菌ペプチドに対して感受性が低いか?. 日本細菌学雑誌. 2004. 59. 1. 145-145
落合恭子, 應原一久, 小松澤均, 菅井基行, 橋本公二, 佐山浩二. マウス上皮細胞の抗菌ペプチドの発現. 日本細菌学雑誌. 2003. 58. 1. 281-281

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Lectures and oral presentations (44)：

Rheumatoid arthritis affected by periodontogenic bacterium, Porphyromonas gingivalis and SDGs
(Th 76th Annual Meeting of Japanese Stomatological Sciety 2022)
The pathology of periodontal disease and its effect on systemic diseases
(2022)
The mechanism of ACPA as a pathogenic factor in the progression of rheumatoid arthritis
(14th Young Researchers in Advanced Rheumatology (YRAR) 2019)
The mechanism of induction of rheumatois arthritis by ACPA
(Osteoimmunology Seminor 2018 Second Half 2018)
全身性強皮症に出現した歯の骨様組織置換性吸収の症例報告
(第29回日本リウマチ学会中国・四国支部学術集会 2018)

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Awards (5)：

2019/10/25 - 日本歯周病学会理事長第19回日本歯周病学会学術賞歯周病原細菌に対する歯周組織局所の免疫応答が及ぼす全身疾患への影響に関する研究
2019/10 - NPO法人日本歯周病学会日本歯周病学会学術賞歯周病原細菌に対する歯周組織局所の免疫応答が及ぼす全身疾患への影響に関する研究
2019/05/24 - 日本歯周病学会理事長 2018年度日本歯周病学会奨励賞 Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration
2018/11/17 - Japanese Association for Dental Research President The 66th Japanese Association for Dental Research / Joseph Lister Award 2018 First prize
2015/11/05 - 日本歯科医学会優秀発表賞歯周病原細菌Porphyromonas gingivalisが産生するメチルメルカプタン抑制作用を有する漢方の臨床応用

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