Research field (2)：
Biological, health, and medical informatics
, Structural biochemistry
Research keywords (5)：
Virtual screening
, Drug design
, Protein design
, Structure prediction
, Protein folding
Research theme for competitive and other funds (3)：
2018 - 2021 Designing high affinity therapeutic nanobodies through the incorporation of unnatural a mino acids
2018 - 2021 Development of Protein Design Methods and Their Experimental Verification
2016 - 2019 Discovery of human Glutaminyl Cyclase inhibitors for the treatment of Alzheimer's disease
Papers (115)：
Johannes Schimunek, Philipp Seidl, Katarina Elez, Tim Hempel, Tuan Le, Frank Noé, Simon Olsson, Lluís Raich, Robin Winter, Hatice Gokcan, et al. A community effort in SARS-CoV-2 drug discovery. Molecular informatics. 2024. 43. 1. e202300262
Kundan Solanki, Sajjan Rajpoot, Ashutosh Kumar, Kam Y J Zhang, Tomokazu Ohishi, Nik Hirani, Khandu Wadhonkar, Pramod Patidar, Qiuwei Pan, Mirza S Baig. Structural analysis of spike proteins from SARS-CoV-2 variants of concern highlighting their functional alterations. Future virology. 2022
Almasul Alfi, Aleksandr Popov, Ashutosh Kumar, Kam Y. J. Zhang, Svetlana Dubiley, Konstantin Severinov, Shunsuke Tagami. Cell-Free Mutant Analysis Combined with Structure Prediction of a Lasso Peptide Biosynthetic Protease B2. ACS Synthetic Biology. 2022
Wei Chen, Qi Chen, Ashutosh Kumar, Xi Jiang, Kam Y J Zhang, Qing Yang. Structure-based virtual screening of highly potent inhibitors of the nematode chitinase CeCht1. Journal of enzyme inhibition and medicinal chemistry. 2021. 36. 1. 1198-1204
Parismita Kalita, Aditya K. Padhi, Kam Y.J. Zhang, Timir Tripathi. Corrigendum to “Design of a peptide-based subunit vaccine against novel coronavirus SARS-CoV-2” [Microbial Pathog. 145 (2020) 104236](S0882401020305234)(10.1016/j.micpath.2020.104236). Microbial Pathogenesis. 2021. 160
Suryavathi Viswanadhapalli, Kalarickal V. Dileep, Kam Y.J. Zhang, Hareesh B. Nair, Ratna K. Vadlamudi. Targeting LIF/LIFR signaling in cancer. Genes and Diseases. 2021
Education (3)：
1986 - 1989 University of York Physics PhD
1982 - 1984 Peking University Chemistry Master of Science
1978 - 1982 Peking University Chemistry Bachelor of Science
Work history (6)：
2018/04 - 現在 RIKEN, Kanagawa, Japan. Center for Biosystems Dynamics Research Team Leader
2013/04 - 2018/03 RIKEN, Kanagawa, Japan. Center for Life Science Technologies Team Leader
2009/01 - 2013/03 RIKEN, Saitama, Japan. Advanced Science Institute Unit Leader
2002/04 - 2008/12 Plexxikon, Inc., Berkeley, California, USA. Structural Biology Director of Structural Biology
1994/11 - 2001/06 Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. Division of Basic Sciences Assistant Member
1989/11 - 1994/10 University of California at Los Angeles, California, USA. Molecular Biology Institute and Department of Chemistry and Biochemistry, Postdoctoral Research Fellow
