Hiwa Ryosuke

ヒワリョウスケ | Hiwa Ryosuke

Affiliation and department：
Job title： Assistant Professor

Research field (3)： Allergies and connective tissue disease , Immunology , Immunology

Research keywords (5)： Nuclear receptor NR4A family , T cell tolerance , B cell tolerance , MHC class II , ANCA-associated vasculitis

Research theme for competitive and other funds (8)：

2022 - 2025 NR4A低分子アゴニストによる自己免疫疾患の治療効果について
2022 - 2025 Define efficacy of small molecule agonist of NR4A for the treatment of autoimmune diseases
2022 - 2025 Development of treatment for systemic lupus erythematosus by targeting nuclear receptor NR4A
2023 - 2024 核内受容体NR4Aによる関節リウマチの病態解明と治療応用
2022 - 2023 核内受容体NR4Aを標的とした関節リウマチの治療開発

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Papers (46)：

Mayu Shiomi, Ryu Watanabe, Shogo Matsuda, Takuya Kotani, Ayana Okazaki, Yuichi Masuda, Tsuneyasu Yoshida, Mikihito Shoji, Ryosuke Tsuge, Keiichiro Kadoba, et al. Long-term efficacy of mepolizumab in patients with eosinophilic granulomatosis with polyangiitis: a propensity score matching analysis in the multicenter REVEAL cohort study. Frontiers in Immunology. 2024. 15
Hideaki Tsuji, Ran Nakashima, Takahiro Yasumi, Tsuneo Sasai, Yuki Ichimura, Mirei Shirakashi, Hideo Onizawa, Ryosuke Hiwa, Koji Kitagori, Shuji Akizuki, et al. Differences in the autoantibody phenotypes and long-term outcomes between juvenile- and adult-idiopathic inflammatory myopathies. Seminars in arthritis and rheumatism. 2024. 68. 152530-152530
Tsuneo Sasai, Ran Nakashima, Tomohiro Handa, Yasuhiko Yamano, Yasuhiro Kondo, Shogo Matsuda, Takuya Kotani, Hiromi Tomioka, Ryo Tachikawa, Keisuke Tomii, et al. Anti-interferon gamma-inducible protein 16 antibodies: Identification of a novel autoantigen in idiopathic interstitial pneumonia and its clinical characteristics based on a multicenter cohort study. Clinical immunology (Orlando, Fla.). 2024. 110372-110372
Ryota Naito, Ryosuke Hiwa, Ryuta Inaba, Kosaku Murakami, Akihiko Kitoh, Yo Kaku, Teruasa Murata, Yuki Ichimura, Naoko Okiyama, Ichizo Nishino, et al. A Case of Vesiculobullous Dermatomyositis with Anti-NXP-2 Antibody without Malignancy. Modern rheumatology case reports. 2024
Mayu Shiomi, Ryu Watanabe, Shogo Matsuda, Takuya Kotani, Ayana Okazaki, Yuichi Masuda, Tsuneyasu Yoshida, Mikihito Shoji, Ryosuke Tsuge, Keiichiro Kadoba, et al. Factors associated with drug retention of mepolizumab in patients with eosinophilic granulomatosis with polyangiitis: A multicentre REVEAL cohort study. Modern rheumatology. 2024

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MISC (14)：

山口恵利帆, 田淵裕也, 新川雄高, 辻英輝, 鬼澤秀夫, 北郡宏次, 日和良介, 秋月修治, 中嶋蘭, 村上孝作, et al. リウマチ性疾患における感染症全身性エリテマトーデスの加療中に、播種性スケドスポリウム症による脳膿瘍とノカルジア症を合併した1例. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2022. 66回. 463-463
岩下晶穂, 田淵裕也, 中窪悠登, 辻英輝, 鬼澤秀夫, 北郡宏次, 日和良介, 秋月修治, 中嶋蘭, 村上孝作, et al. リウマチ性疾患における感染症慢性再発性多発性骨髄炎の治療中に抗IFN-γ自己抗体陽性播種性NTM症による髄膜炎を発症し、リツキシマブ投与を行った1例. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2022. 66回. 463-463
増尾優輝, 吉藤元, 日和良介, 田中望美, 秋月修治, 村上孝作, 中嶋蘭, 大村浩一郎, 三森経世. 全身性エリテマトーデスに自己免疫性好中球減少症、びまん性肺胞出血、IgA腎症を合併した1例. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2019. 63回. 835-835
山木妙夏, 日和良介, 中嶋蘭, 秋月修治, 藏本伸生, 村上孝作, 橋本求, 吉藤元, 田中真生, 大村浩一郎, et al. 神経ベーチェット病と傍腫瘍性小脳変性症の合併が疑われた一例. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2018. 62回. 851-851
日和良介, 三森経世. 意識障害患者を診る意識障害を来す疾患の診療膠原病. 月刊臨床と研究. 2017. 94. 9

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Lectures and oral presentations (5)：

Negative Regulation of B Cell Responses by Nr4a1 and Nr4a3
(Keystone Symposia, B Cell Renaissance: Epigenetics, Regulation and Immunotherapy 2020)
Trough concentration of mycophenolic acid correlates with renal function and serum albumin level in Japanese patients with SLE
(Annual European Congress of Rheumatology (EULAR) 2018 2018)
Myeloperoxidase/HLA class II complexes are targets for autoantibodies in ANCA-associated vasculitis
(The 13th International Workshop on Autoantibodies and Autoimmunity 2016)
Clinical characteristics of rheumatoid factor-positive or negative subsets of anti-citrullinated peptide/protein antibody-negative rheumatoid arthritis
(2013 ACR/ARHP Annual Meeting 2013)
Only Rheumatoid factor-positive subset of anti-citrullinated peptide/protein antibody-negative rheumatoid arthritis seroconverts to anti-citrullinated peptide/protein antibody-positive
(2013 ACR/ARHP Annual Meeting 2013)

Education (3)：

2016 - 2017 Kyoto University Faculty of Medicine Department of Rheumatology and Clinical Immunology
2012 - 2016 Kyoto University Graduate School of Medicine Department of Rheumatology and Clinical Immunology
2001 - 2007 Kobe University School of Medicine Faculty of Medicine

Professional career (1)：

医学博士 (京都大学大学院医学研究科)

Work history (6)：

2021/09 - 現在 Kyoto University Hospital Department of Rheumatology and Clinical Immunology Assistant Professor
2018/11 - 2021/08 University of California, San Francisco Division of Rheumatology, Department of Medicine Postdoctoral Scholar
2017/04 - 2018/10 Kyoto University Hospital Department of Rheumatology and Clinical Immunology Physician
2011/04 - 2012/03 Tenri Hospital General Internal Medicine Chief Resident
2009/04 - 2011/03 Tenri Hospital General Internal Medicine Senior Resident

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Awards (5)：

2020 - Uehara Memorial Foundation Research Fellowship Define the role of the Nr4a family in regulating B cell tolerance and B cell immune responses
2018 - Japan Rheumatism Foundation Travel Bursary for Presentation in International Conference (EULAR)
2016 - International Workshop Award HLA-DRB1 analysis utilizing consecutive data of rheumatoid factor (RF) identified a genetically unique subset among rheumatoid arthritis and distinct genetic background of RF levels from anti-cyclic citrullinated peptide antibodies.
2016 - The 13th International Workshop on Autoantibodies and Autoimmunity Award for Exceptional Abstract and Presentation "Myeloperoxidase/HLA class II complexes are targets for autoantibodies in ANCA-associated vasculitis."
2013 - 日本リウマチ財団国際学会におけるリウマチ性疾患調査・研究発表助成 (ACR) Only Rheumatoid factor-positive subset of anti-citrullinated peptide/protein antibody-negative rheumatoid arthritis seroconverts to anti-citrullinated peptide/protein antibody-positive.

Association Membership(s) (4)：

日本リウマチ学会 , 日本内科学会 , 日本臨床免疫学会 , 日本免疫学会

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