Kurosawa Ryo

クロサワリョウ | Kurosawa Ryo

Affiliation and department：
Job title： Research Scientist

Research field (1)： Cardiology

Research keywords (7)： Cardiogenomics , Bioinformatics , Multi-Omics Analysis , Molecular Biology , Drug Screening , Coronary Heart Disease , Pulmonary Hypertension

Research theme for competitive and other funds (4)：

2022 - 2025 冠攣縮性狭心症に対する世界初のゲノムワイド関連解析による遺伝要因の同定
2019 - 2022 次世代型先制医療実現のための肺高血圧症病因蛋白群の抽出と治療法開発
2019 - 2022 Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension High-Throughput Screening of 5562 Compounds.
2017 - 2019 化合物ライブラリーを利用した新規肺高血圧症治療薬の開発

Papers (35)：

Keiko Hikino, Satoshi Koyama, Kaoru Ito, Yoshinao Koike, Masaru Koido, Takayoshi Matsumura, Ryo Kurosawa, Kohei Tomizuka, Shuji Ito, Xiaoxi Liu, et al. RNF213 Variants, Vasospastic Angina, and Risk of Fatal Myocardial Infarction. JAMA cardiology. 2024
Tomohiko Shindo, Kenta Ito, Tsuyoshi Ogata, Ryo Kurosawa, Kumiko Eguchi, Yuta Kagaya, Kenichiro Hanawa, Yuhi Hasebe, Kensuke Nishimiya, Takashi Shiroto, et al. A randomized, double-blind, placebo-controlled pilot trial of low-intensity pulsed ultrasound therapy for refractory angina pectoris. PLOS ONE. 2023. 18. 6. e0287714-e0287714
Takashi Nakata, Tomohiko Shindo, Kenta Ito, Kumiko Eguchi, Yuto Monma, Sadamitsu Ichijo, Rie Ryoke, Wakako Satoh, Kazunori Kumasaka, Haruka Sato, et al. Beneficial Effects of Low-Intensity Pulsed Ultrasound Therapy on Right Ventricular Dysfunction in Animal Models. JACC: Basic to Translational Science. 2023. 8. 3. 283-297
Kazuo Miyazawa, Kaoru Ito, Masamichi Ito, Zhaonan Zou, Masayuki Kubota, Seitaro Nomura, Hiroshi Matsunaga, Satoshi Koyama, Hirotaka Ieki, Masato Akiyama, et al. Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction. Nature genetics. 2023. 55. 2. 187-197
Hirotaka Ieki, Kaoru Ito, Mike Saji, Rei Kawakami, Yuji Nagatomo, Kaori Takada, Toshiya Kariyasu, Haruhiko Machida, Satoshi Koyama, Hiroki Yoshida, et al. Deep learning-based age estimation from chest X-rays indicates cardiovascular prognosis. Communications medicine. 2022. 2. 1. 159-159

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MISC (8)：

Ryo Kurosawa, Kaoru Ito. Up-to-date Genetic Diagnosis and Treatment for Cardiovascular Diseases: Understanding Polygenic Risk Scores for Coronary Artery Disease. Heart View. 2024. 28. 5. 416-420
Masamichi Nogi, Kimio Satoh, Shun Kudo, Junichi Omura, Nobuhiro Kikuchi, Taijyu Satoh, Shinichiro Sunamura, Ryo Kurosawa, Tohmohiro Ohtsuki, Kazuhiko Numano, et al. Protective Roles of Small GTP-Binding Protein GDP Dissociation Stimulator Against Angiotensin II-Induced Thoracic Aortic Aneurysm Formation and Rupture in Mice -A Possible Novel Therapeutic Target. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2017. 37
Ryo Kurosawa, Kimio Satoh, Nobuhiro Kikuchi, Junichi Omura, Taijyu Satoh, Masamichi Nogi, Shinichiro Sunamura, Kazuhiko Numano, Kota Suzuki, Mohammad Abdul Hai Siddique, et al. Celastramycin Inhibits Pulmonary Arterial Smooth Muscle Cell Proliferation and Ameliorates Hypoxia-induced Pulmonary Hypertension in Mice. CIRCULATION. 2016. 134
Shinichiro Sunamura, Kimio Satoh, Kota Suzuki, Shun Kudo, Shohei Ikeda, Kikuchi Nobuhiro, Omura Junichi, Taijyu Satoh, Ryo Kurosawa, Masamichi Nogi, et al. Crucial Role of ROCK1 to Maintain Contractile Cardiac Function in Response to Chronic Pressure-Overload in Mice. CIRCULATION. 2016. 134
Mohammad Abdul Hai Siddique, Kimio Satoh, Ryo Kurosawa, Md. Elias Al-Mamun, Nobuhiro Kikuchi, Junichi Omura, Taijyu Satoh, Masamichi Nogi, Shinichiro Sunamura, Hiroaki Shimokawa. Identification of Emetine as a Novel Therapeutic Agent for Pulmonary Hypertension in Rats -High-throughput Screening of 5,562 Compounds. CIRCULATION. 2016. 134

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Patents (4)：

生薬成分を含む肺高血圧症の予防又は治療剤
メベンダゾール及び/もしくはイトラコナゾール又はその塩を含有する、肺高血圧症の予防又は治療剤
不飽和複素5員環含有化合物を含有する肺高血圧症の予防又は治療剤
生薬成分を含む肺高血圧症の予防又は治療剤

Books (4)：

Heart View Vol.28 No.5 P.4-8 (416-420), 2024
MEDICAL VIEW 2024
Japanese Journal of Circulation Research VOL45 NO.3/2022
The Japanese Society for Circulation Research 2022
Cardioangiology 92.5
2022
Pulmonary Hypertension Update(Vol.6 No.1)
Medical Review Co., Ltd. 2020 ISBN:9784779225109

Lectures and oral presentations (22)：

Basic research and cardiologist
(2022)
スクリーニングによる新規肺高血圧症治療薬Celastramycinの発見(奨励賞受賞講演)
(第5回日本肺高血圧・肺循環学会学術集会 2020)
化合物スクリーニングによる新規肺高血圧症治療薬の発見(Meet the Expert)
(第84回日本循環器学会学術集会 2020)
Identification of Celastrol as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension and Right Ventricular Failure through Suppression of Basigin/Cyclophilin A(Oral Presentation)
(第84回日本循環器学会学術集会 2020)
肺高血圧症、右心不全治療薬としてのBasigin/Cyclophilin A 阻害薬 Celastrol の同定(YIAセッション研究奨励賞優秀賞受賞)
(第49回日本心脈管作動物質学会 2020)

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Awards (10)：

2020/09 - Japanese Pulmonary Circulation and Pulmonary Hypertension Society Japanese Pulmonary Circulation and Pulmonary Hypertension Society 2020 Society Encouragement Award (Basic)
2020/02 - Japanese Society for Circulation Research Research The 49th Annual Japanese Society for Circulation Research Research Incentive Award
2019/09 - European Society of Cardiology European Society of Cardiology Young Reseachers Award(Pulmonary Circulation & Right Ventricular Function)
2019/03 - Japanese Circulation Society The 83th Japanese Circulation Society Young Investigator's Award Basic Research (First Prize)
2018/06 - Japanese Pulmonary Circulation and Pulmonary Hypertension Society The 3rd Annual Scientific Meeting of the Japanese Pulmonary Circulation and Pulmonary Hypertension Society Young Investigator Award

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Association Membership(s) (7)：

American Society of Human Genetics , European Society of Cardiology , Japanese Circulation Society , American Heart Association , the Japanese Pulmonary Circulation and Pulmonary Hypertension Society , The Japanese Society of Internal Medicine , The Japanese Circulation Society

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