Onogi Yasuhiro

Affiliation and department：

Research field (1)： Metabolism and endocrinology

Research keywords (6)：組換えアデノ随伴ウイルスによる遺伝子組換え , Single-nucleus RNA-seq , Adipocytes , Obesity , Macrophage , Pericytes

Research theme for competitive and other funds (5)：

2024 - 2028 脂肪組織の可塑性メモリーを規定するエピゲノム制御による肥満リバウンド抑止法の開発
2023 - 2025 脂肪細胞機能の多様性を生み出す細胞ネットワークの同定
2020 - 2022 Role of P2X receptor 5 on Thermogenesis in Brown Adipocytes of Mice
2017 - 2019 Impacts of pericyte behavior on vascular niche maintaining adipocyte progenitor cells in obesity
2012 - 2015 Enhanced PDGF signaling contributes adipose tissue angiogenesis, expansion, and systemic glucose intolerance in obesity.

Papers (14)：

Akira Okekawa, Tsutomu Wada, Yasuhiro Onogi, Yuki Takeda, Yuichiro Miyazawa, Masakiyo Sasahara, Hiroshi Tsuneki, Toshiyasu Sasaoka. Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity. Molecular Medicine. 2024. 30. 1
Tsutomu Wada, Yuichiro Miyazawa, Misa Ikurumi, Kento Fuse, Akira Okekawa, Yasuhiro Onogi, Shigeru Saito, Hiroshi Tsuneki, Toshiyasu Sasaoka. A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice. Nutrition & Metabolism. 2023. 20. 1
Hiroshi Tsuneki, Takahiro Maeda, Shinjiro Takata, Masanori Sugiyama, Koyuki Otsuka, Hinako Ishizuka, Yasuhiro Onogi, Emi Tokai, Chiaki Koshida, Kanta Kon, et al. Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity. Cell Reports. 2022. 41. 3. 111497-111497
Elena López-Gonzales, Lisa Lehmann, Francisco Javier Ruiz Ojeda, René Hernández-Bautista, Irem Altun, Yasuhiro Onogi, Ahmed Elagamy Khalil, xue liu, Andreas Israel, Siegfried Ussar. L-Serine Supplementation Blunts Fasting-Induced Weight Regain by Increasing Brown Fat Thermogenesis. Nutrients. 2022. 14. 9. 1922-1922
Jiefu Wang, Yasuhiro Onogi, Martin Krueger, Josef Oeckl, Ruth Karlina, Inderjeet Singh, Stefanie M. Hauck, Regina Feederle, Yongguo Li, Siegfried Ussar. PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes. Molecular Metabolism. 2022. 101508-101508

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MISC (15)：

Yasuhiro Onogi, Siegfried Ussar. Regulatory networks determining substrate utilization in brown adipocytes. Trends in Endocrinology & Metabolism. 2022
Yasuhiro Onogi, Siegfried Ussar. Is epiploic fat the dermal fat of the intestine?. Gut. 2021. gutjnl-2021
Yasuhiro Onogi, Ahmed Elagamy Mohamed Mahmoud Khalil, Siegfried Ussar. Identification and characterization of adipose surface epitopes. Biochemical Journal. 2020. 477. 13. 2509-2541
Watanabe Eri, Wada Tsutomu, Onogi Yasuhiro, Tsuneki Hiroshi, Sasaoka Toshiyasu. Anagliptin, a DPP-4 Inhibitor, Attenuates Diet-Induced Obesity by Modulating Adipose Tissue Angiogenesis in Mice. DIABETES. 2017. 66. A541-A541
和田努, 小野木康弘, 松澤崇俊, 山本誠士, 石井陽子, 笹原正清, 恒枝宏史, 笹岡利安. 脂肪組織の肥大化における脂肪血管ペリサイトの局在変化の意義. 日本内分泌学会雑誌. 2017. 93. 1. 268-268

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Books (1)：

Lectures and oral presentations (6)：

シングルセル解析による肥満の未病探索
(第98回日本糖尿病学会中部地方会 2024)
Comparison of Nuclear Preparation for Single-Nucleus RNA-seq of Adipose Tissue
(ADA 84th Scientific Sessions 2024)
Impact of SDF1/CXCR4 signaling on pericyte mobilization during obesity development.
(The 17th Japan-Korea Diabetic Nephropathy Seminar)
Pro-inflammatory macrophages promote vascular remodeling in white adipose tissue during diet-induced obesity.
(The 17th Japan-Korea Diabetic Nephropathy Seminar)
A novel mechanism of adipose-tissue angiogenesis via PDGF-B signaling in fat tissue expansion during obesity.
(International Symposium of Korea University College of Medicine BK21 Plus Graduate Program)

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Education (1)：

Professional career (1)：

Work history (3)：

2022/08 - 現在 University of Toyama
2019/04 - 2022/08 Institute for Diabetes and Obesity, Helmholtz Center Munich RG Adipocytes and Metabolism Postdoctoral Fellow
2017/04 - 2019/03 富山大学大学院医学薬学研究部(薬学系) 病態制御薬理学博士研究員

Awards (9)：

2020/06 - The Alexander von Humboldt Foundation Postdoctoral Research Fellowship
2019/04 - The Uehara Memorial Foundation Postdoctoral Fellowship
2017/05 - The 60th annual meeting of the Japan Diabetes Society Young Investigator Award
2016/12 - The 28th annual meeting of the study group of Molecular Diabetology in Japan Young Investigator Award and Research Travel Grant
2015/12 - The 27th annual meeting of the study group of Molecular Diabetology in Japan Research Travel Grant

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Association Membership(s) (2)：

Japanease Society for Bioinfomatics , 日本糖尿病学会

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