Rchr
J-GLOBAL ID：202101014826704483
Update date: Jan. 31, 2024
WATANABE TOSHIKI
ワタナベ トシキ | WATANABE TOSHIKI
Affiliation and department：
Job title：
Professor
Research field (1)：
Hematology and oncology
Research keywords (1)：
ATL, HTLV
Research theme for competitive and other funds (45)：
- 2022 - 2028 Platform of Supporting Cohort Study and Biospecimen Analysis
- 2020 - 2025 Japan-Australia joint study for epidemiological survey of HTLV-1 a/c subtypes and elucidation of their unique pathogenic mechanims
- 2016 - 2021 コホート・生体試料支援プラットフォーム
- 2016 - 2020 Research on risk factors for the development of ATL: Long-term cohort study of HTLV-1-infected individuals.
- 2015 - 2018 The role of the viral protein Rex in the host-pathogen interaction between HTLV-1 and T cells.
- 2014 - 2017 Integrated analysis of abnormal expression profiles that define phenotype of ATL cells
- 2010 - 2016 Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- 2012 - 2015 Implication of NMD inhibition by Rex to the host cell leukemogenesis
- 2011 - 2014 Oncogene addiction of ATL cells and abnormal Polycomb-miRNA-signal transduction
- 2011 - 2012 HTLV-1 hijacks T-cell differentiation/function by deregulatingHelios gene expression
- 2008 - 2010 Pursuit of a new system for a high throughput screening of drugs to develop a new strategy of prevention and treatment of ATL
- 2005 - 2009 Long term follow up study and prevention of ATL occurrence among HTLV-1 carriers : a nationwide cohort study
- 2007 - 2008 HTLV-1によるTリンパ球腫瘍化機構としてのRNA品質管理機構NMDの撹乱
- 2006 - 2007 Analysis of molecular basis for occurance of Hodgkin lympnoma and anaplastic large cell lymphoma
- 2006 - 2007 Abnormalities in TCR signal transduction in T cell non-Hodgkin's lymphoma as a basis for a new classification system.
- 2004 - 2005 Anti-tumor immunity after non-myeloablative cord blood cell transplantation for Adult T cell leukemia/lymphoma
- 2004 - 2005 Analyses of phenotypic changes of Hodgkin and Reed-Stemberg cells to anaplastic large cell lymphoma cells by p80.
- 2004 - 2005 Studies on abnormalities of membrane receptor signaling in malignant lymphoma cells as a basis of diagnosis and treatment
- 2003 - 2005 Development of model mice of adult T-cell leukemia for evaluation of new therapeutic agents
- 2000 - 2004 ATL発症高危険群の長期追跡と発病予防の検討
- 2002 - 2003 Analyses of molecular bases of Hodgkin lymphoma by CD30-NF-kB pathway.
- 2002 - 2003 Molecular analysis of aberrant signal transduction of membrane receptors as a basis for diagnosis and treatment of malignant lymphomas
- 2001 - 2001 潜伏HIV再活性化における細胞周期依存的・選択的CpG脱メチル化機構
- 2000 - 2001 Regulation Mechanisms of HIV LTR Demethylation through Reactivation Signaling
- 2000 - 2000 HIV潜伏感染と再活性化におけるCpGメチル化制御の意義
- 1999 - 1999 HTLV-1 TaxによるゲノムDNAメチル化制御異常の誘導機構
- 1999 - 1999 HIV潜伏感染と再活性化におけるヒストンアセチル化制御の役割に関する
- 1999 - 1999 TRAFシグナル伝達抑制分子としてのPIAS1の機能の解析
- 1999 - 1999 HTLV-I抗体陽性者の長期追跡
- 1997 - 1998 Mechanisms of suppression on cytokine expression in HTLV-1-infected T cell clones by aqueous humor
- 1996 - 1998 Development of new methods in diagnosis and treatment of tumors by the targeting of chimeric protein
- 1997 - 1997 NFκB活性化制御におけるHIVTatとCD30シグナル伝達系の相互作用
- 1996 - 1997 Characterization of genes involved in the multistep leukemogenesis of ATL
- 1996 - 1996 性ホルモンを介したHTLV-1遺伝子発現調節と感染リンパ球の機能異常の解析
- 1994 - 1996 HTLV-1による細胞がん化の分子機構
- 1994 - 1996 Information Exchange on Cancer Research with North American
- 1995 - 1995 ATL腫瘍細胞におけるL-セレクチン過剰発現の分子機構の解析
- 1994 - 1994 HTLV-1 TaxによるLECAM-1プロモーター活性化の分子機構の解析
- 1993 - 1994 Studies for developing a laboratory diagnostic system for cancers by means of PCR that is applicale to clinical samples such as urine and stool
- 1993 - 1993 ATL腫瘍細胞におけるLECAM-1発現異常の分子機構の解析
- 1992 - 1992 ATL腫瘍細胞の高カルシウム血症因子(PTHγP)過剰発現の分子機構の解明
- 1991 - 1991 HTLVー1感染Tリンパ球の機能異常,特にリンパ球ホ-ミング異常の分子機構の解明
- 1990 - 1991 Analysis of the mechanism of transactivation of gene expression of malignant hypercalcemia factor (PTHrP) by HTLV-1
- 1989 - 1990 ヒト白血病ウイルスの遺伝子発現と成人T細胞白血病の発症機構
- 1987 - 1989 Hypercalcemic Factors in ATL
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Papers (165)：
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Asami Yamada, Jun-Ichirou Yasunaga, Lihan Liang, Wenyi Zhang, Junya Sunagawa, Shinji Nakaoka, Shingo Iwami, Yasunori Kogure, Yuta Ito, Keisuke Kataoka, et al. Anti-HTLV-1 immunity combined with proviral load as predictive biomarkers for adult T-cell leukemia-lymphoma. Cancer science. 2023
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Hiroo Katsuya, Hideaki Nakamura, Aya Maeda, Keitaro Ishii, Toshiaki Nagaie, Haruhiko Sano, Haruna Sano, Hidekazu Itamura, Sho Okamoto, Toshihiko Ando, et al. HTLV-1 cell-free DNA in plasma as a potential biomarker in HTLV-1 carriers and adult T-cell leukemia-lymphoma. eJHaem. 2023
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Mariko Watanabe, Hiromi Hatsuse, Kazuaki Nagao, Yuetsu Tanaka, Toshiki Watanabe, Ryouichi Horie. CD30 stimulation induces multinucleation and chromosomal instability in HTLV-1-infected cell lines. International Journal of Hematology. 2023. 118. 1. 75-87
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Takuro Kameda, Keisuke Kataoka, Ayako Kamiunten, Michihiro Hidaka, Hiroaki Miyoshi, Nobuaki Nakano, Kisato Nosaka, Makoto Yoshimitsu, Jun-Ichirou Yasunaga, Yasunori Kogure, et al. Integrated genetic and clinical prognostic factors for aggressive adult T-cell leukemia/lymphoma. Haematologica. 2023. 108. 8. 2178-2191
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Makoto Nakashima, Atae Utsunomiya, Toshiki Watanabe, Ryouichi Horie, Kaoru Uchimaru. The oncogenic driving force of CD30 signaling-induced chromosomal instability in adult T-cell leukemia/lymphoma. Cancer science. 2022. 114. 4. 1556-1568
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MISC (96)：
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山岸 誠, 鈴木 穣, 窪川 美雪, 久世 裕太, 横溝 明香里, 鈴木 絢子, 小林 誠一郎, 中島 誠, 宇都宮 與, 森島 聡子, et al. 多層シングルセルプラットフォームによるクローン構造解析とTCR経路変異の生物学的意義の検討. 日本癌学会総会記事. 2020. 79回. OE7-7
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勝屋 弘雄, Islam Saiful, 伊東 潤平, 宮里 パオラ, 内山 良一, 畑 裕之, 佐藤 和雄, 八木下 尚子, 新谷 奈津美, 上野 孝治, et al. 自然感染した患者におけるHTLV-1プロウイルスの性質についてのウイルスDNAキャプチャーシークエンス分析による解析(The nature of HTLV-1 provirus in naturally infected individuals analyzed by viral DNA-capture-seq approach). 日本リンパ網内系学会会誌. 2019. 59. 118-118
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勝屋 弘雄, Islam Saiful, 伊東 潤平, 宮里 パオラ, 内山 良一, 畑 裕之, 佐藤 和雄, 八木下 尚子, 新谷 奈津美, 上野 孝治, et al. 自然感染した患者におけるHTLV-1プロウイルスの性質についてのウイルスDNAキャプチャーシークエンス分析による解析(The nature of HTLV-1 provirus in naturally infected individuals analyzed by viral DNA-capture-seq approach). 日本リンパ網内系学会会誌. 2019. 59. 113-113
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Lucy B Cook, Shigeo Fuji, Olivier Hermine, Ali Bazarbachi, Juan Carlos Ramos, Lee Ratner, Steve Horwitz, Paul Fields, Alina Tanase, Horia Bumbea, et al. Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2019. 37. 8. 677-687
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佐藤 知雄, 八木下 尚子, 新谷 奈津美, 井上 永介, 古田 梨愛, 渡邉 俊樹, 内丸 薫, 松岡 雅雄, 松本 直樹, 長谷川 泰弘, et al. HAM治療薬としての抗CCR4抗体製剤(モガムリズマブ). NEUROINFECTION. 2018. 23. 2. 236-236
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Patents (1)：
Committee career (4)：
- 2020 - 現在 厚生労働省「HTLV-1対策推進協議会HTLV-1感染症法上の取扱いを検討する小委員会」 委員長
- 2015/02 - 現在 厚生労働省「希少がん医療・支援のあり方に関する検討会」 委員
- 2011/07 - 現在 厚生労働省「HTLV-1対策推進協議会」 座長
- 2010/10 - 内閣府「HTLV-1特命チーム」 オブザーバー
Awards (2)：
- 2008/05 - 財団法人 癌研究会 第13回比較腫瘍学常陸宮賞 サルのT細胞白血病ウイルスの研究
- 2007 - International Retrovirology Association (IRA) David McFarlin Award
Association Membership(s) (7)：
日本ウイルス学会
, 日本リンパ網内系学会
, International Association for Comparative Research of Leukemia and Related Diseases(IACRLRD)
, 日本HTLV-1学会
, International Retrovirology Association(IRVA)
, 日本血液学会
, 日本癌学会
