Eguchi Takahiro

エグチタカヒロ | Eguchi Takahiro

Affiliation and department：

Research field (4)： Cell biology , Laboratory animal science , Animals: biochemistry, physiology, behavioral science , Molecular biology

Research keywords (4)：サルコペニア , 運動ニューロン , skeletal muscle , neuromuscular junction

Research theme for competitive and other funds (6)：

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Papers (11)：

Takahiro Eguchi, Tohru Tezuka, Yuji Watanabe, Akane Inoue-Yamauchi, Hiroshi Sagara, Manabu Ozawa, Yuji Yamanashi. Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice. iScience. 2024. 27. 2. 108997
Takumi Sugimoto, Chihiro Sakamaki, Tokushi Kimura, Takahiro Eguchi, Shinji Miura, Yasutomi Kamei. Peroxisome proliferator-activated receptor γ coactivator 1α regulates downstream of tyrosine kinase-7 (Dok-7) expression important for neuromuscular junction formation. Scientific Reports. 2024. 14. 1
Takahiro Eguchi, Yuji Yamanashi. Adeno-associated virus-mediated expression of an inactive CaMKIIβ mutant enhances muscle mass and strength in mice. Biochemical and Biophysical Research Communications. 2022. 589. 192-196
Ryo Ueta, Satoshi Sugita, Yoshihiko Minegishi, Akira Shimotoyodome, Noriyasu Ota, Noboru Ogiso, Takahiro Eguchi, Yuji Yamanashi. DOK7 Gene Therapy Enhances Neuromuscular Junction Innervation and Motor Function in Aged Mice. iScience. 2020. 23. 8. 101385-101385
Takahiro Eguchi, Tohru Tezuka, Takayasu Fukudome, Yuji Watanabe, Hiroshi Sagara, Yuji Yamanashi. Overexpression of Dok-7 in skeletal muscle enhances neuromuscular transmission with structural alterations of neuromuscular junctions: Implications in robustness of neuromuscular transmission. Biochemical and biophysical research communications. 2020. 523. 1. 214-219

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Books (4)：

Lectures and oral presentations (11)：

CDK5活性化因子p35を起点とした神経筋シナプス形成・維持制御メカニズムの解析
(第8回日本筋学会学術集会 2022)
骨格筋における変異型CaMKIIβの強制発現は筋肥大を誘導する
(第7回日本筋学会学術集会 2021)
A study of therapeutic interventions aimed at enhancing neuromuscular junction innervation and skeletal muscle mass
(The 16th International Symposium of the Institute Network for Biomedical Sciences 2021)
神経筋接合部(NMJ)の形成・維持シグナルとNMJを標的とした治療技術
(第76回日本体力医学会大会 2021)
DOK7遺伝子を用いた神経筋接合部(NMJ)の形成増強治療は老齢マウスにおけるNMJの神経結合を増強し、運動機能と筋力を強化する
(第6回日本筋学会学術集会 2020)

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Education (2)：

2015 - 2018 The University of Tokyo Graduate School of Frontier Sciences
2013 - 2015 The University of Tokyo Graduate School of Frontier Sciences Department of Medical Genome Sciences

Work history (4)：

2023/03 - 現在 National Center for Geriatrics and Gerontrogy
2019/04 - 2023/02 The Institute of Medical Science, The University of Tokyo Division of Genetics, Department of Cancer Biology Assistant professor
2018/04 - 2019/03 The Institute of Medical Science, The University of Tokyo Division of Genetics, Department of Cancer Biology
2017/04 - 2018/03 The Institute of Medical Science, The University of Tokyo

Awards (3)：

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