Mihara Taiki

ミハラタイキ | Mihara Taiki

Affiliation and department：
Homepage URL (1)： http://www.vm.a.u-tokyo.ac.jp/yakuri/

Research field (1)： Veterinary medicine

Research keywords (5)：炎症 , 肝線維症 , α7ニコチン性アセチルコリン受容体 , Pharmacology , Veterinary medical science

Research theme for competitive and other funds (8)：

2023 - 2027 Role of gastrointestinal stromal cells in the gastrointestinal motility and pathogenesis and repair of gastrointestinal diseases.
2024 - 2026 線維芽細胞増殖因子23に着目した肝硬変および続発する合併症の増悪メカニズムの解明
2023 - 2025 腹膜透析に起因する腹膜劣化に対する新規予防・治療・診断薬の開発
2022 - 2025 Catalyst Unit
2022 - 2024 線維芽細胞増殖因子23が担う肝-骨の臓器連環を介した骨粗鬆症の新規発症メカニズム

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Papers (12)：

Taiki Mihara, Yoshiharu Tsuru, Tamaki Kurosawa, Yuma Nonoshita, Yuki Yamakawa, Masatoshi Hori. Pemigatinib suppresses liver fibrosis and subsequent osteodystrophy in mice. Hepatology Communications. 2024
Nanami Ishida, Tamaki Kurosawa, Momo Goto, Noriyuki Kaji, Yayoi Tokunaga, Taiki Mihara, Masatoshi Hori. Dasatinib promotes muscle differentiation and disrupts normal muscle regeneration. International Journal of Medical Sciences. 2024. 21. 8. 1461-1471
Taiki Mihara, Masatoshi Hori. Nicotine aggravates liver fibrosis via α7 nicotinic acetylcholine receptor expressed on activated hepatic stellate cells. Hepatology Communications. 2024. 8. 6
Hitomi Kimura, Takako Yamazaki, Taiki Mihara, Noriyuki Kaji, Kazuhisa Kishi, Masatoshi Hori. Purinergic P2X7 receptor antagonist ameliorates intestinal inflammation in postoperative ileus. The Journal of veterinary medical science. 2022. 84. 4. 610-617
Chizuru Sogawa-Fujiwara, Yasuhiro Fujiwara, Atsuki Hanagata, Qunhui Yang, Taiki Mihara, Noriyuki Kaji, Tetsuo Kunieda, Masatoshi Hori. Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery. BMC research notes. 2021. 14. 1. 438-438

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MISC (17)：

山田舜己, 三原大輝, 黒澤珠希, 岸和寿, 神崎萌絵, 丸山彩, 水戸部祐子, 大橋(土井)雅津代, 堀正敏. 鉄剤は胃排泄を遅延させ,その遅延は5-HT3受容体阻害薬によって改善される. 日本神経消化器病学会プログラム・抄録集. 2023. 25th
堀正敏, 三原大輝, 後藤もも, 徳永弥月, 伊藤浩人, 茶圓貴志, 黒澤珠希, 北嶋聡. Food Biohazard Study for cultured cells: 1; Gene expression analysis using mouse fibroblasts and bovine tracheal smooth muscle cells. Journal of Toxicological Sciences. 2023. 48. Supplement (CD-ROM). S149-S149
三原大輝, 堀正敏. Nicotine exacerbates liver fibrosis via alpha7 nicotinic acetylcholine receptors. Journal of Toxicological Sciences. 2023. 48. Supplement (CD-ROM). S96-S96
徳永弥月, 黒澤珠希, 三原大輝, 堀正敏. 妊娠期の高血糖環境が子の筋発育不良を生じる機序の解明. 日本筋学会学術集会プログラム・抄録集. 2023. 9th. 134-134
徳永弥月, 黒澤珠希, 三原大輝, 堀正敏. 妊娠期の高血糖環境が子の筋発育不良を生じる機構の解明. 日本獣医学会学術集会講演要旨集. 2023. 166th

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Patents (1)：

Books (1)：

Lectures and oral presentations (24)：

ニコチンは肝星細胞に発現するα7ニコチン性アセチルコリン受容体を介して肝臓線維化を増悪する
(2024)
Liver-bone crosstalk mediated by fibroblast growth factor 23: Pemigatinib suppresses liver fibrosis and subsequent osteodystrophy
(The 1st Annual Meeting of the Japanese Cytokine Society 2024)
Pemigatinib suppresses liver fibrosis and subsequent osteoporosis
(The 97th Annual Meeting of the Japanese Pharmacological Society 2023)
Osteopontin is an etiologic factor and a potential novel biomarker of peritoneal dysfunction
(2023)
ニコチンはα7ニコチン性アセチルコリン受容体を介して肝臓線維化を増悪する
(第50回日本毒性学会学術年会 2023)

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Education (4)：

2017 - 2021 The University of Tokyo Graduate School of Agricultural and Life Sciences Veterinary Medical Sciences
2013 - 2017 The University of Tokyo Faculty of Agriculture Veterinary Medical Sciences
2011 - 2013 The University of Tokyo College of Arts and Sciences
2008 - 2011 栄光学園高等学校

Professional career (2)：

Work history (2)：

2021/04 - 現在 The University of Tokyo Graduate School of Agricultural and Life Sciences Assistant Professor
2018/04 - 2021/03 Japan Society for the Promotion of Science

Awards (8)：

2023/12 - 92th JPS Annual Meeting Award
2023/07 - Young Investigator Award
2023/06 - 日本毒性学会第50回日本毒性学会学術年会優秀研究発表賞
2022/09 - 日本獣医学会学術集会優秀発表賞
2022/06 - Japanese Society of Interferon & Cytokine Research ICIS 2022 Travel Award Novel osteoporosis mechanism: liver-bone crosstalk mediated by fibroblast growth factor 23

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Association Membership(s) (6)：

日本腹膜透析医学会 , 日本毒性学会 , 日本獣医学会 , 日本サイトカイン学会 , 日本実験動物学会 , 日本薬理学会

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