Rchr
J-GLOBAL ID：202101016351549693   Update date: Aug. 03, 2024

Kokubo Kota

コクボ コウタ | Kokubo Kota
Affiliation and department：
Chiba University Graduate School of Medicine

About Chiba University Graduate School of Medicine


Research field  (1)： Immunology
Research keywords  (6)： Asthma ,  Airway inflammation ,  Type 2 helper T cell ,  Tissue resident T cell ,  CD4+ T cell ,  Immunology
Research theme for competitive and other funds  (3)：
  • 2022 - 2024 Research for a novel oxidative stress scavenging mechanisms of Txnip that induce asthma exacerbation
  • 2021 - 2023 Research for the mechanisms of asthma exacerbation through memory Th2 cell formation by oxidative stress control mechanisms
  • 2021 - 2022 Elucidation of the Mechanism of Asthma Exacerbation via Memory Th2 Cell Formation by Oxidative Stress Regulation Mechanism
Papers (26)：
  • Ami Aoki, Chiaki Iwamura, Masahiro Kiuchi, Kaori Tsuji, Atsushi Sasaki, Takahisa Hishiya, Rui Hirasawa, Kota Kokubo, Sachiko Kuriyama, Atsushi Onodera, et al. Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Patients. Journal of Clinical Immunology. 2024. 44. 4
  • 熊谷 仁, 木内 政宏, 小久保 幸太, 飯沼 智久, 小野 啓, 花澤 豊行, 古関 明彦, 中山 俊憲, 平原 潔, 横手 幸太郎. USP7-STAT3-granzyme経路はIL-5/IL-13産生Th2細胞の分化を促進しアレルギー性炎症を制御する. 日本臨床分子医学会学術総会プログラム・抄録集. 2024. 59回. 42-42
  • Shigeru Tanaka, Takuya Yamamoto, Arifumi Iwata, Masahiro Kiuchi, Kota Kokubo, Tomohisa Iinuma, Takahiro Sugiyama, Toyoyuki Hanazawa, Kiyoshi Hirahara, Kei Ikeda, et al. Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease. Arthritis research & therapy. 2024. 26. 1. 55-55
  • Jin Kumagai, Masahiro Kiuchi, Kota Kokubo, Hiroyuki Yagyu, Masahiro Nemoto, Kaori Tsuji, Ken Nagahata, Atsushi Sasaki, Takahisa Hishiya, Miki Onoue, et al. The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 49. e2302903120
  • Atsushi Onodera, Kota Kokubo, Mikiko Okano, Miki Onoue, Masahiro Kiuchi, Chiaki Iwamura, Tomohisa Iinuma, Motoko Y. Kimura, Nobuyuki Ebihara, Toyoyuki Hanazawa, et al. Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases. Pharmacology & Therapeutics. 2023. 247. 108445-108445
ｍore...
MISC (8)：
  • 平原潔, 小久保幸太, 中山俊憲. CD4陽性T細胞と肺の線維化. 医学のあゆみ. 2022. 283. 1. 4-9
  • 小久保幸太, 平原潔. 局所免疫応答における組織常在性メモリーT細胞. 臨床免疫・アレルギー科. 2022. 78. 4. 438-443
  • 青木亜美, 辻香織, 小久保幸太, 木内政宏, 平原潔, 中山俊憲. ベンラリズマブによる好酸球性炎症組織局所での抗体依存性細胞傷害活性についての検討. アレルギー. 2021. 70. 6/7
  • 中山俊憲, 市川智巳, 小久保幸太, 木内政宏, 青木亜美, 平原潔. 病原性Th2細胞による難治性アレルギー性気道炎症の病態制御. アレルギー. 2021. 70. 6/7
  • 小久保幸太, 平原潔, 中山俊憲. CD103highTreg細胞による肺繊維化抑制. 臨床免疫・アレルギー科. 2020. 74. 2. 180-184
ｍore...
Lectures and oral presentations  (8)：
  • Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism
    (2024)
  • The cellular and molecular mechanisms underlying the induction of fibrotic responses in the lung
    (第48回日本免疫学会総会 2019)
  • Epigenetics in the induction and maintenance of effector and memory Th2 cells
    (第47回日本免疫学会総会 2018)
  • Pathogenic Th population disease induction model: From the recruitment of eosinophils to the induction of fibrosis
    (第47回日本免疫学会総会 2018)
  • Menin controls the memory Th2 cell function by maintaining the epigenetic integrityof Th2 cells
    (The 2nd cMAV Symposium Tokyo 2018)
ｍore...
Education (3)：
  • 2017 - 2021 Chiba University Graduate School of Medical and Pharmaceutical Sciences
  • 2015 - 2017 Chiba University Graduate School of Medical and Pharmaceutical Sciences
  • 2010 - 2015 Chiba University Faculty of Science
Professional career (1)：
  • Doctor of Medicine (Chiba University)
Work history (1)：
  • 2021/04 - 現在 Graduate School of Medicine, Chiba University Department of Immunology instructor
Awards (8)：
  • 2024/03 - Japanese Society for Immunology Best Presentation Award in The 52nd Annual Meeting of the Japanese Society for Immunology
  • 2024/02 - 千葉大学大学院医学研究院 千葉大学医学部スカラーシップ指導者賞
  • 2021/03 - 文部科学省 博士課程教育リーディングプログラム (免疫システム調節治療学推進リーダー養成プログラム) 最優秀大学院学生賞
  • 2021/03 - 千葉大学 医学薬学府博士課程 学業成績優秀者表彰
  • 2019/04 - 文部科学省 博士課程教育リーディングプログラム (免疫システム調節治療学推進リーダー養成プログラム) 優秀大学院学生賞
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Association Membership(s) (1)：
日本免疫学会
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