Rchr
J-GLOBAL ID:202101018063799203   Update date: Jun. 17, 2024

Inagaki Hiroto

イナガキ ヒロト | Inagaki Hiroto
Affiliation and department:
Research field  (2): Cell biology ,  Molecular biology
Research keywords  (2): mRNAポリA鎖伸長 ,  mRNA医薬
Research theme for competitive and other funds  (2):
  • 2023 - 2025 Ataxin-2の機能破綻が2型脊髄小脳変性症を引き起こす分子メカニズムの解明
  • 2021 - 2025 外来性ウイルスRNAを分解する生体防御機構の全容解明
Papers (6):
  • Ryota Yamagishi, Hiroto Inagaki, Jun Suzuki, Nao Hosoda, Haruka Sugiyama, Kazunori Tomita, Takashi Hotta, Shin-Ichi Hoshino. Concerted action of ataxin-2 and PABPC1-bound mRNA poly(A) tail in the formation of stress granules. Nucleic acids research. 2024
  • Tomoya Kitano, Hiroto Inagaki, S Hoshino. The impact of single-stranded RNAs on the dimerization of double-stranded RNA-dependent protein kinase PKR. Biochemical and biophysical research communications. 2024. 719. 150103-150103
  • Koichi Ogami, Yuka Oishi, Kentaro Sakamoto, Mayu Okumura, Ryota Yamagishi, Takumi Inoue, Masaya Hibino, Takuto Nogimori, Natsumi Yamaguchi, Kazuya Furutachi, et al. mTOR- and LARP1-dependent regulation of TOP mRNA poly(A) tail and ribosome loading. Cell reports. 2022. 41. 4. 111548-111548
  • Hiroto Inagaki, Nao Hosoda, Shin-Ichi Hoshino. DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery. Biochemical and biophysical research communications. 2021. 553. 9-16
  • Hiroto Inagaki, Nao Hosoda, Hitomi Tsuiji, Shin-Ichi Hoshino. Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation. The Journal of biological chemistry. 2020. 295. 47. 15810-15825
more...
Books (1):
  • mRNAの制御機構の解明と治療薬・ワクチンへの活用
    技術情報協会 2023 ISBN:9784861049378
Lectures and oral presentations  (1):
  • mRNA医薬翻訳効率化技術の開発
    (日本核酸医薬学会 第7回年会 2022)
Education (2):
  • 2016 - 2021 Nagoya City University
  • 2010 - 2016 Nagoya City University Medicin Medicin
Professional career (1):
  • Doctor of Pharmacy (Nagoya City University)
Work history (3):
  • 2021/11 - 現在 Nagoya City University
  • 2021/09 - 2021/10 Nagoya City University
  • 2021/04 - 2021/08 Nagoya City University
Awards (3):
  • 2021/05 - 日本生化学会中部支部例会・シンポジウム 日本生化学会中部支部奨励賞受賞 DDX6は脊髄小脳変性症原因因子Ataxin-2/PAPD4による細胞質ポリA鎖伸長の正の制御因子である
  • 2019/07 - 第21回日本RNA学会年会 優秀賞 脊髄小脳変性症原因因子Ataxin-2はポリA鎖伸長を介して標的mRNAの翻訳を性に制御する
  • 2014/07 - 第16回日本RNA学会年会 優秀賞 脊髄小脳変性症の原因遺伝子Ataxin-2はmRNAデキャッピングを促進する
Association Membership(s) (3):
日本薬学会 ,  日本生化学会 ,  日本RNA学会
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