Takeda Kazuki

タケダカズキ | Takeda Kazuki

Affiliation and department：
Job title： Lecturer/ Junior Associate Professor
Homepage URL (1)： https://kitasatoxlab.jp/

Research field (3)： Biological, health, and medical informatics , Environmental effects of chemicals , Veterinary medicine

Research keywords (16)： SDGs , QSAR , Drug metabolism , Analytical chemistry , Pesticide , Computational Toxicology , Machine Learning , Computational Science , Bioinfomatics , Pharmacokinetics , Rodenticide , Wildlife , Cytochrome P450 , Environmental Polution , Environmental Chemical , Toxicology

Research theme for competitive and other funds (9)：

2021 - 2026 Adaptive evolution/change in mammals to exogenous chemicals (xenobiotics)
2023 - 2026 Development and clinical application of a non-invasive drug sensitivity assessment method for ex situ conservation of threatened avian species
2022 - 2026 Analysis of human and animal toxicological effects and mechanisms of environmental pollution in Africa
2023 - 2025 Establishment of a Novel Method for Predicting Off-Target Toxicity by Comprehensive Binding Simulation
2023 - 2024 3D画像解析を活用した肉用牛におけると畜時の適切な姿勢および放銃位置の探索

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Papers (16)：

Ryohto Koharazawa, Mayu Hayakawa, Kazuki Takeda, Kotone Miyazaki, Chisato Tode, Yoshihisa Hirota, Yoshitomo Suhara. Exploring 2-methyl-substituted vitamin K3 derivatives with potent inhibitory activity against the 3CL protease of SARS-CoV-2. Bioorganic & Medicinal Chemistry Letters. 2024
Kazuki Takeda, Keita Shimizu, Miyu Sato, Masafumi Katayama, Shouta M.M. Nakayama, Kotaro Tanaka, Yoshinori Ikenaka, Takuma Hashimoto, Ryuichi Minato, Yusuke Oyamada, et al. Sensitivity assessment of diphacinone by pharmacokinetic analysis in invasive black rats in the Bonin (Ogasawara) Archipelago, Japan. Pesticide Biochemistry and Physiology. 2024. 199. 105767-105767
Kazuki Takeda, Taki Saito, Sakura Sasaki, Akifumi Eguchi, Makoto Sugiyama, Saeka Eto, Kio Suzuki, Ryo Kamata. Toxicity Assessment of Mixed Exposure of Nine Perfluoroalkyl Substances at Concentrations Relevant to Daily Intake. Toxics. 2024
Kraisiri Khidkhan, Fuyu Yasuhira, Aksorn Saengtienchai, Chaiyan Kasorndorkbua, Ratiwan Sitdhibutr, Kohei Ogasawara, Hikaru Adachi, Yukiko Watanabe, Keisuke Saito, Hidefumi Sakai, et al. Evaluation of anticoagulant rodenticide sensitivity by examining in vivo and in vitro responses in avian species, focusing on raptors. Environmental Pollution. 2023. 122837-122837
Kazuki Takeda, Taki Saito, Sakura Sasaki, Akifumi Eguchi, Makoto Sugiyama, Kio Suzuki, Saeka Eto, Ryo Kamata. Subchronic Toxicity Assessment of Perfluoroalkyl Substances by Mixed Exposure of Nine Substances at Daily Intake Relevant Concentration. BioRxiv. 2023

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MISC (27)：

Kazuki Takeda. Protein Structure Prediction by Deep Learning for Environmental Toxicology Research. Newsletter of the Japan Society of Endocrine Disruptors Research. 2024. 27. 1. 5
Kazuki Takeda. ~From Fieldwork to AI ~ Veterinary Environmental Toxicology by Anything Goes. Promotion of Veterinary Science. 2023. 11. 28-30
川合佑典, 池中良徳, 池中良徳, 生城真一, 西川美宇, 一色乃亜, 武田一貴, 中山翔太, 中山翔太, 久保田彰, et al. Evolutionary history of UGT genes involved in xenobiotic metabolism in mammals and birds and their relationship to plants. 日本進化学会大会プログラム・講演要旨集(Web). 2023. 25th
日置七海, 北野泰佑, 朱子達, 武田一貴, 折野宏一, 吉川泰永. ゾウFANCL-FANCB間の相互作用はヒトホモログより強い. 日本獣医学会学術集会講演要旨集. 2023. 166th
Moyu Miyamae, Satoru Nagaoka, Sanae Yamamoto, Ryo Kamata, Kazuki Takeda. Exploration of In Vivo Factors Contributing to Differences in Pharmacokinetics between cis-trans Isomers of Antihemostatic Rodenticides. Journal of Toxicological Sciences. 2023. 48. Supplement (CD-ROM)

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Books (3)：

Experimental Pharmacology and Toxicology, 4th ed. (written in Japanese)
Bun-eido shuppan co. ltd. 2023 ISBN:9784830032868
Essential Textbook for Pet Nurse(written in Japanese)
Gakken 2022 ISBN:9784780914672
Encyclopedia of Pests
Asakura Publishing Co.,Ltd. 2020 ISBN:9784254640489

Lectures and oral presentations (70)：

Drug Discovery Chemistry and Toxicology in Age of Post-AlphaFold2
(The 25th Continuing Education Course of the Japanese Society of Toxicology 2024)
Evaluation of Vitamin K Derivatives Directed at Inhibition of Enzymes Involved in SARS-CoV-2 Proliferation
(The 144th Annual Meeting of the Pharmaceutical Society of Japan)
Search for Molecules Responsible for Differences in Drug Efficacy between cis-trans Isomers of Warfarin Rodenticides
(6th International Chemical Hazard Symposium 2024)
Evaluation of sensitivity differences of anticoagulant rodenticide, diphacinone in four rodent strains by PK/PD analysis and PBPK modeling.
(GastroPlus® Users Meeting 2023 2023)
Environmentally harmful paper recycling? sensitizer compounds in paper recycling effluent, exerts dioxin-like effects on zebrafish (Danio rerio) via aryl hydrocarbon receptors
(The international joint meeting of the 23rd International Conference on Cytochrome P450 (ICCP450) and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (JSSX) (2023 ICCP450/JSSX International Joint meeting) 2023)

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Education (2)：

2016 - 2020 Hokkaido University Graduate School of Veterinary Medicine
2010 - 2016 Hokkaido University School of Veterinary Medicine

Professional career (1)：

Ph.D. (Veterinary sciences) (Graduate School of Veterinary Medicine, Hokkaido University)

Work history (6)：

2023/04 - 現在 Kitasato University School of Veterinary Medicine Lecturer/Junior Associate Professor
2020/09 - 2023/03 Kitasato University School of Veterinary Medicine Assistant Professor
2020/04 - 2020/08 Tokyo Institute of Technology School of Computing JSPS Superlative Postdoctoral Fellow
2017/04 - 2020/03 Hokkaido University Graduate School of Veterinary Medicine Research Fellowship for Young Scientists, Japan Society for the Promotion of Science
2016/04 - 2020/03 Hokkaido University Faculty of Veterinary Medicine Attending Veterinarian

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Committee career (2)：

2023/10 - 現在 Digital Toxicology Conference Organizing Committee
2023/07 - 2024/07 The 51st Annual Meeting of the Japanese Society of Toxicology Women and Young Researcher Program Committee

Awards (8)：

2021/06 - Japan Society for Environmental Chemistry Royal Society of Chemistry Award Estimating susceptibility of rodenticide by molecular dynamics & machine learning using 3D structure of vitamin K epoxide reductase
2018/07 - The Japanese Society of Toxicology Best Graduate Student Award, the 45th Annual Meeting of the Japanese Society of Toxicology What Makes Super Rats "Super"? ~Exploring the Mechanism of Acquiring Resistance in Rodenticide-Resistant Black Rats Found in Tokyo
2018/03 - Society of Toxicology SOT 57th Annual Meeting and ToxExpo, Molecular and Systems Biology SS Graduated Student Honorable mention Novel Mechanism of Rodenticide (warfarin) Resistance of Wild Rats in Tokyo -Enhanced Pentose Phosphate Pathway Causes Rapid Metabolism of Warfarin -
2018/03 - Society of Toxicology SOT 57th Annual Meeting and ToxExpo, Comparative & Veterinary specialty section, Graduated Student Travel Award Novel Mechanism of Rodenticide (warfarin) Resistance of Wild Rats in Tokyo -Enhanced Pentose Phosphate Pathway Causes Rapid Metabolism of Warfarin -
2017/09 - Graduate School of Veterinary Medicine, Hokkaido University 5th SaSSOH (Sapporo Summer Symposium for One Health) The best oral presentation award Novel investigation of mechanism of rodenticide resistance ~ enhanced pentose phosphate pathway causes rapid metabolism of warfarin ~

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Association Membership(s) (5)：

Society of Environmental Toxicology and Chemistry , Society of Toxicology , The Molecular Biology Society of Japan , The Japanese Society of Toxicology , Japan Society for Environmental Chemistry

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