Research theme for competitive and other funds (2):
2023 - 2026 悪性髄膜腫に対する末梢血および臍帯血由来NK細胞を用いた免疫細胞療法の開発
2022 - 2025 TIGITノックアウトヒトNK細胞を用いた膠芽腫に対する新規治療法の開発
Papers (27):
Ryosuke Matsuda, Ryosuke Maeoka, Takayuki Morimoto, Tsutomu Nakazawa, Yudai Morisaki, Kenta Nakase, Shohei Yokoyama, Masashi Kotsugi, Yasuhiro Takeshima, Shuichi Yamada, et al. Preoperative blood counts predict overall survival in patients undergoing surgical removal of brain metastasis. World Neurosurgery. 2024
Takayuki Morimoto, Tsutomu Nakazawa, Ryosuke Maeoka, Ryosuke Matsuda, Mitsutoshi Nakamura, Fumihiko Nishimura, Shuichi Yamada, Ichiro Nakagawa, Young-Soo Park, Takahiro Tsujimura. Bulk RNA sequencing reveals the comprehensive genetic characteristics of human cord blood-derived natural killer cells. Regenerative therapy. 2024. 25. 367-376
Ryosuke Matsuda, Masatoshi Hasegawa, Tetsuro Tamamoto, Nobuyoshi Inooka, Takayuki Morimoto, Ryosuke Maeoka, Tsutomu Nakazawa, Tomoko Ochi, Toshiteru Miyasaka, Shigeto Hontsu, et al. Clinical Results and Hematologic Predictors of Linear Accelerator-Based Stereotactic Radiosurgery or Fractionated Stereotactic Radiotherapy for Brain Metastasis in Patients Aged 75 Years or Older: A Retrospective Study. World Neurosurgery. 2024. 183. e944-e952
Takayuki Morimoto, Tsutomu Nakazawa, Ryosuke Matsuda, Ryosuke Maeoka, Fumihiko Nishimura, Mitsutoshi Nakamura, Shuichi Yamada, Young-Soo Park, Takahiro Tsujimura, Ichiro Nakagawa. Antitumor Effects of Intravenous Natural Killer Cell Infusion in an Orthotopic Glioblastoma Xenograft Murine Model and Gene Expression Profile Analysis. International Journal of Molecular Sciences. 2024. 25. 4. 2435-2435
Tsutomu Nakazawa, Ryosuke Maeoka, Takayuki Morimoto, Ryosuke Matsuda, Mitsutoshi Nakamura, Fumihiko Nishimura, Shuichi Yamada, Ichiro Nakagawa, Young-Soo Park, Toshihiro Ito, et al. An efficient feeder-free and chemically-defined expansion strategy for highly purified natural killer cells derived from human cord blood. Regenerative therapy. 2023. 24. 32-42
CRISPR-Cas9-mediated TIM3 knockout in human Natural Killer Cells Enhances Growth Inhibitory Effects on Human Glioma Cells.
(American Association of Immunology (AAI) "IMMUNOLOGY2021" 2021)
Efficient blockade of TIM3 by CRISPR-Cas9 in Human Natural killer cells Enhances an antitumor effect in Human Glioblastoma Cells.
(2020)
Characterization of a novel type NK cell line KHYG-1 carrying EGFRvIII-specific CAR in glioblastoma cells.
(American Association of Immunology (AAI) ”IMMUNOLOGY2020" 2020)