Morimoto Takayuki

Affiliation and department：

Research field (5)： Genomics , Tumor diagnostics and therapeutics , Tumor biology , Immunology , Neurosurgery

Research keywords (5)：脳腫瘍 , グリオーマ , がん免疫 , がん免疫療法 , 遺伝子工学

Research theme for competitive and other funds (2)：

2023 - 2026 悪性髄膜腫に対する末梢血および臍帯血由来NK細胞を用いた免疫細胞療法の開発
2022 - 2025 TIGITノックアウトヒトNK細胞を用いた膠芽腫に対する新規治療法の開発

Papers (31)：

Ryosuke Matsuda, Ryosuke Maeoka, Takayuki Morimoto, Tsutomu Nakazawa, Noriaki Tokuda, Masashi Kotsugi, Yasuhiro Takeshima, Kentaro Tamura, Shuichi Yamada, Fumihiko Nishimura, et al. Effect of Intraoperative Ventricular Opening on Recurrence Patterns Following Bis-Chloroethyl-Nitrosourea Wafer Implantation for Newly Diagnosed Glioblastoma. Journal of Korean Neurosurgical Society. 2024
Tsutomu Nakazawa(corresponding author), Takayuki Morimoto, Ryosuke Maeoka, Kengo Yamada, Ryosuke Matsuda, Mitsutoshi Nakamura, Fumihiko Nishimura, Shuichi Yamada, Young-Soo Park, Takahiro Tsujimura, et al. Characterization of HIF-1α knockout primary human natural killer cells including populations in allogeneic glioblastoma. International Journal of Molecular Sciences. 2024. 25. 11. 5896
Ryosuke Matsuda, Ryosuke Maeoka, Takayuki Morimoto, Tsutomu Nakazawa, Yudai Morisaki, Shohei Yokoyama, Masashi Kotsugi, Yasuhiro Takeshima, Shuichi Yamada, Fumihiko Nishimura, et al. Pre-treatment systemic inflammation response index and systemic immune inflammation in patients with primary central nerve system lymphoma as a useful prognostic indicator. Journal of Neuro-Oncology. 2024
Ryosuke Matsuda, Ryosuke Maeoka, Takayuki Morimoto, Tsutomu Nakazawa, Yudai Morisaki, Kenta Nakase, Shohei Yokoyama, Masashi Kotsugi, Yasuhiro Takeshima, Shuichi Yamada, et al. Preoperative blood counts predict overall survival in patients undergoing surgical removal of brain metastasis. World Neurosurgery. 2024
Takayuki Morimoto, Tsutomu Nakazawa, Ryosuke Maeoka, Ryosuke Matsuda, Mitsutoshi Nakamura, Fumihiko Nishimura, Shuichi Yamada, Ichiro Nakagawa, Young-Soo Park, Takahiro Tsujimura. Bulk RNA sequencing reveals the comprehensive genetic characteristics of human cord blood-derived natural killer cells. Regenerative therapy. 2024. 25. 367-376

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MISC (19)：

Takayuki Morimoto, Tsutomu Nakazawa, Ryosuke Maeoka, Ichiro Nakagawa, Takahiro Tsujimura, Ryosuke Matsuda. Natural Killer Cell-Based Immunotherapy against Glioblastoma. International Journal of Molecular Sciences. 2023. 24. 3
森本尭之, 永田清, 徳永英守, 出口潤, 小谷有希子, 二階堂雄次. 鉄欠乏性貧血が原因と考えられた脳皮質静脈血栓症の1例. 脳卒中の外科. 2021. 49. 2. 145-150
細川真, 本山靖, 中川一郎, 高村慶旭, 下間惇子, 森本尭之, 速水宏達, 古田隆徳, 佐藤文哉, 角谷美帆, et al. 中大脳動脈瘤破裂における外減圧の必要性. 奈良県医師会医学会年報. 2020. 33. 1. 93-93
中川一郎, 朴憲秀, 木次将史, 古田隆徳, 佐藤文哉, 速水宏達, 森本尭之, 山田修一, 本山靖, 明珍薫, et al. 解離性脳動脈瘤に対する種々のモニタリングを駆使したステント併用コイル塞栓術. 脳血管内治療. 2019. 4. Suppl. S59-S59
中川一郎, 朴憲秀, 木次将史, 古田隆徳, 佐藤文哉, 速水宏達, 森本尭之, 山田修一, 本山靖, 明珍薫, et al. ステント併用脳動脈瘤コイル塞栓術におけるActive Target PRU managementの現在と未来. 脳血管内治療. 2019. 4. Suppl. S99-S99

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Lectures and oral presentations (12)：

転移性脳腫瘍に対する定位放射線治療後に外科的切除を要した症例の検討
(第26回日本脳腫瘍の外科学会 2021)
CRISPR-Cas9-mediated TIM3 knockout in human Natural Killer Cells Enhances Growth Inhibitory Effects on Human Glioma Cells.
(American Association of Immunology (AAI) "IMMUNOLOGY2021" 2021)
深部に局在する転移性脳腫瘍に対する覚醒下手術の治療経験
(第19回日本Awake Surgery学会 2020)
Efficient blockade of TIM3 by CRISPR-Cas9 in Human Natural killer cells Enhances an antitumor effect in Human Glioblastoma Cells.
(2020)
Characterization of a novel type NK cell line KHYG-1 carrying EGFRvIII-specific CAR in glioblastoma cells.
(American Association of Immunology (AAI) ”IMMUNOLOGY2020" 2020)

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Education (1)：

2008 - 2014 Nara Medical University Medical Faculty

Work history (2)：

2019/04 - 現在 Nara Medical University
2014/04 - 2019/03 市立奈良病院脳神経外科

Association Membership(s) (7)：

日本脳腫瘍の外科学会 , 日本分子脳神経外科学会 , 日本ゲノム編集学会 , 日本がん免疫学会 , 日本脳卒中学会 , 日本脳卒中の外科学会 , 日本脳神経外科学会

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