Rchr
J-GLOBAL ID：202101019807953989
Update date: Feb. 01, 2024
Hitomi Junichi
ヒトミ ジュンイチ | Hitomi Junichi
Affiliation and department：
Research field (1)：
Molecular biology
Research keywords (1)：
cancer, cell death, liver, cell cycle, inflammation
Research theme for competitive and other funds (4)：
- 2021 - 2025 Elucidation of new function of Noggin, a BMP inhibitor, in cerebral infarction and spinal cord injury
- 2021 - 2024 Molecular analysis of cell death independent function of necroptosis mediator MLKL in liver cancer cells.
- 2010 - 2011 脊髄小脳変性症マウスの運動失調回復の検討
- 2010 - 2010 脊髄小脳変性症1型モデルマウスにおける神経変性機構の解明と遺伝子治療効果の検討
Papers (18)：
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Yasushi Ito, Dimitry Ofengeim, Ayaz Najafov, Sudeshna Das, Shahram Saberi, Ying Li, Junichi Hitomi, Hong Zhu, Hongbo Chen, Lior Mayo, et al. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science. 2016. 353. 6299. 603-608
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D E Christofferson, Y Li, J Hitomi, W Zhou, C Upperman, H Zhu, S A Gerber, S Gygi, J Yuan. A novel role for RIP1 kinase in mediating TNFα production. Cell Death & Disease. 2012. 3. 6. e320-e320
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Junichi Hitomi, Dana E. Christofferson, Aylwin Ng, Jianhua Yao, Alexei Degterev, Ramnik J. Xavier, Junying Yuan. Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway. Cell. 2008. 135. 7. 1311-1323
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Alexei Degterev, Junichi Hitomi, Megan Germscheid, Irene L Ch'en, Olga Korkina, Xin Teng, Derek Abbott, Gregory D Cuny, Chengye Yuan, Gerhard Wagner, et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology. 2008. 4. 5. 313-321
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Futoshi Yukioka, Shinsuke Matsuzaki, Keisuke Kawamoto, Yoshihisa Koyama, Junichi Hitomi, Taiichi Katayama, Masaya Tohyama. Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis. Neurochemistry International. 2008. 52. 4-5. 683-687
ｍore...
MISC (4)：
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加藤信介, 山岸覚, 小山佳久, 片山泰一, 谷口学, 人見淳一, 松崎伸介, 加藤昌明, 青木正志, 糸山泰人, et al. ヒトFALS・ALSマウスとIn vitro ALSモデルとの共通点に関する基盤研究. 臨床神経学. 2008. 48. 10. 770-770
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Taiichi Katayama, Kazunori Imaizumi, Takayuki Manabe, Junichi Hitomi, Takashi Kudo, Masaya Tohyama. Induction of neuronal death by ER stress in Alzheimer’s disease. Journal of Chemical Neuroanatomy. 2004. 28. 1-2. 67-78
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山岸覚, 山口淳, 人見淳一, 片山泰一, 遠山正弥, 加藤昌昭, 青木正志, 糸山泰人. Development of a new treatment technique for amyotrophic lateral sclerosis. Influence of endoplasmic reticulum stress on development of amyotrophic lateral sclerosis (ALS). 筋萎縮性側索硬化症の病因・病態に関わる新規治療法の開発に関する研究班 平成15年度 研究報告書. 2004
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人見淳一, 片山泰一, 恵口豊, 工藤喬, 矢寺美佐子, 辻本賀英, 遠山正弥. 小胞体ストレスによって活性化されるカスペース. 解剖学雑誌. 2003. 78. Supplement
Books (1)：
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ネクロプトーシスシグナリングの網羅的解析
羊土社 2009 ISBN:9784758100489
Lectures and oral presentations (2)：
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プログラム型ネクローシスであるネクロプトーシス分子機構の解析
(日本解剖学会総会・全国学術総会 2010)
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小胞体ストレス特異的に活性化されるヒトカスペースの探索
(第46回日本神経化学会 2003)
Education (3)：
- 2000 - 2004 Osaka University Graduate School of Medicine
- 1998 - 2000 Osaka University Graduate School of Medicine
- 1994 - 1998 University of Tsukuba School of Life and Environmental Sciences, College of Biological Sciences
Professional career (1)：
Work history (1)：
- 2019/06 - 現在 Asahikawa Medical University
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