Seko Yoshinori

セコヨシノリ | Seko Yoshinori

Research field (1)： Cardiology

Research theme for competitive and other funds (20)：

2022 - 2025 川崎病冠動脈炎における酸化ストレス誘導蛋白(ORAIP)の役割と新規治療薬の開発
2021 - 2024 胸腹部大動脈術後脊髄再灌流障害の新たな細胞障害機序の解明と治療法の開発
2019 - 2022 Elucidation of the relationship of novel apoptosis-inducing substances to the pathophysiology of pulmonary arterial hypertension
2003 - 2004 Identification of the Receptor for ORAIP That Mediates Cardiac Response to Oxidative Stresses and Development of Treatment
2001 - 2002 Identification of the ligands for Cardiac Orphan G protein -Coupled Receptors and Development of T herapy Modulating Cardiac Function

2000 - 2002 心血管系の負荷応答と病態形成:遺伝子転写シグナルと病態生理に基づく治療戦略の確立

1999 - 2001 Development of inhibitors for the activation of cardiovascular interstitial ceils

1999 - 2000 Development of the Specific Immunotherapy for Myocarditis, Dilated Cardiomyopathy(Chronic Myocarditis), and Takayasu Arteritis.

1999 - 2000 Purification and Identification of the Bioactive Subs tance That Mediates Cardiac Response to the Ischemia Reperfusion Stresses and Development of Treatment

1999 - 1999 拡張型心筋症(慢性心筋炎)のモデル動物の作成と治療法開発への応用

1997 - 1998 Elucidation of the Molecular Mechanism of Cardiac Response to the Ischemia Reperfusion Stresses and Establishment of Treatment Based on the Molecular Mechanism

1997 - 1998 Molecular Mechanisms of Genetic Response of Myocardial Cells to Cytotoxic Stress

1997 - 1997 血管平滑筋細胞における転写因子Idの機能と発現調節機序

1995 - 1997 Development of Molecular Biologic Diagnostic and Therapeutic Method of Asymptomatic Myocardial Ischemia and Unstable Angina

1996 - 1996 心筋虚血再灌流障害における細胞内情報伝達機構の解明および抗接着分子療法の確立

1995 - 1995 心筋虚血再灌流障害に対する抗接着分子療法の確立および心筋細胞応答の分子機構の解析

1993 - 1995 The elucidation of the roles of cell-adhesion molecules in heart diseases

1994 - 1994 心筋虚血再灌流障害の細胞内・細胞間分子機構の解明とそれに基づいた予防法の確立

1993 - 1993 心筋虚血再潅流障害の分子機構の解明および接着分子タンパクを用いた予防法の確立

1991 - 1992 Intracellular Signaling of Stretch Mediated Myocyte Growth

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Papers (59)：

Kayoko Sato, Takako Yao, Tsutomu Fujimura, Kimie Murayama, Ko Okumura, Nobuhisa Hagiwara, Yoshinori Seko. Oxidative stress-responsive apoptosis-inducing protein in patients with heterozygous familial hypercholesterolemia. Heart and vessels. 2021. 36. 12. 1923-1932
Masao Kishimoto, Jun Suenaga, Hajime Takase, Kota Araki, Takako Yao, Tsutomu Fujimura, Kimie Murayama, Ko Okumura, Ryu Ueno, Nobuyuki Shimizu, et al. Oxidative stress-responsive apoptosis inducing protein (ORAIP) plays a critical role in cerebral ischemia/reperfusion injury. Scientific reports. 2019. 9. 1. 13512-13512
Yuta Suzuki, Takako Yao, Ko Okumura, Yoshinori Seko, Shigehiko Kitano. Elevation of the vitreous body concentrations of oxidative stress-responsive apoptosis-inducing protein (ORAIP) in proliferative diabetic retinopathy. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2019. 257. 7. 1519-1525
Takako Yao, Tsutomu Fujimura, Kimie Murayama, Ko Okumura, Yoshinori Seko. Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in High Glucose-Induced Apoptosis in Rat Cardiac Myocytes and Murine Pancreatic β-Cells. Cells. 2017. 6. 4
Menno V. Huisman, Kenneth J. Rothman, Miney Paquette, Christine Teutsch, Hans-Christoph Diener, Sergio J. Dubner, Jonathan L. Halperin, Chang Sheng Ma, Kristina Zint, Amelie Elsaesser, et al. The Changing Landscape for Stroke Prevention in AF Findings From the GLORIA-AF Registry Phase 2. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2017. 69. 7. 777-785

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MISC (198)：

世古義規, 野中美希, 呉林なごみ, 上園保仁, 立石健祐, 八尾貴子. Oxidative Stress-responsive Apoptosis Inducing Protein(ORAIP)は癌性悪液質誘発性心臓損傷を媒介する(Oxidative Stress-Responsive Apoptosis Inducing Protein(ORAIP) Mediates Cancer Cachexia-Induced Cardiac Injury). 日本循環器学会学術集会抄録集. 2018. 82回. OJ02-6
山方勇樹, 池田聡司, 中田智夫, 米倉剛, 江口正倫, 古賀聖士, 室屋隆浩, 小出優史, 河野浩章, 八尾貴子, et al. 肺高血圧症患者において酸化ストレス応答アポトーシス誘導蛋白質(ORAIP)の血漿中濃度は肺血行動態と関連している(Plasma Levels of Oxidative Stress-Responsive Apoptosis Inducing Protein(ORAIP) is Associated with Pulmonary Hemodynamics in Patients with Pulmonary Hypertension). 日本循環器学会学術集会抄録集. 2018. 82回. PJ052-2
山方勇樹, 池田聡司, 米倉剛, 古賀聖士, 室屋隆浩, 小出優史, 河野浩章, 八尾貴子, 世古義規, 前村浩二. 肺高血圧症における酸化ストレス応答性アポトーシス誘導タンパク(ORAIP)の意義. 血管. 2018. 41. 1. 35-35
鈴木裕太, 八尾貴子, 世古義規, 北野滋彦. 糖尿病網膜症の硝子体中の酸化ストレス応答性アポトーシス誘導因子ORAIP濃度の解析. 糖尿病合併症. 2017. 31. Suppl.1. 341-341
世古義規, 八尾貴子. 心房細動患者における血漿中oxidative stress-responsive apoptosis inducing protein(ORAIP)濃度の著しい上昇(Marked Elevation of Plasma Levels of Oxidative Stress-Responsive Apoptosis Inducing Protein(ORAIP) in Patients with Atrial Fibrillation). 日本循環器学会学術集会抄録集. 2017. 81回. PJ-335

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