Momose Fumiyasu

モモセフミヤス | Momose Fumiyasu

Affiliation and department：
Job title： Research Assistant Professor

Research field (2)： Tumor diagnostics and therapeutics , Immunology

Research keywords (7)：腫瘍免疫学 , がん免疫療法 , がんワクチン , T細胞療法(TCR-T/CAR-T) , エクソソーム , miRNAs , ドラッグデリバリーシステム(DDS)

Research theme for competitive and other funds (8)：

2023 - 2026 hybrid-TCR法によるがん治療法の検討
2021 - 2026 ヒアルロン酸ナノゲルによるポリペプチドの可溶化・生体内輸送機能解析とワクチンへの応用
2022 - 2025 ヒアルロン酸誘導体がんワクチンのメモリーT細胞誘導作用とがん再発抑制機序の解明
2020 - 2022 CpGによる活性化T細胞エクソソームを介したがん悪性化制御作用及び分子機構の解明
2018 - 2021 Elucidation of ISG-mediated suppression of mesenchymal tumor stromal cells by miRNAs in human T cell-released exosomes

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Papers (8)：

Mikiya Ishihara, Yoshihiro Nishida, Shigehisa Kitano, Akira Kawai, Daisuke Muraoka, Fumiyasu Momose, Naozumi Harada, Yoshihiro Miyahara, Naohiro Seo, Hiroyoshi Hattori, et al. A phase 1 trial of NY-ESO-1-specific TCR-engineered T-cell therapy combined with a lymph node-targeting nanoparticulate peptide vaccine for the treatment of advanced soft tissue sarcoma. International journal of cancer. 2023. 152. 12. 2554-2566
Yoshiyuki Adachi, Fumiyasu Momose, Hiromi Momose, Rui Tada, Naohito Ohno. Potentiation of antitumor activity by antibody drugs and mushroom-derived beta-glucan in the natural killer cell-mediated tumoricidal activities against non-Hodgkin's B-cell lymphoma. Int. J. Med. Mus. 2022
Shohei Iida, Takehisa Nakanishi, Fumiyasu Momose, Masako Ichishi, Kento Mizutani, Yoshiaki Matsushima, Ai Umaoka, Makoto Kondo, Koji Habe, Yoshifumi Hirokawa, et al. IL-17A Is the Critical Cytokine for Liver and Spleen Amyloidosis in Inflammatory Skin Disease. International Journal of Molecular Sciences. 2022. 23. 10. 5726-5726
Eun Jeong Park, Onmanee Prajuabjinda, Zay Yar Soe, Samuel Darkwah, Michael G. Appiah, Eiji Kawamoto, Fumiyasu Momose, Hiroshi Shiku, Motomu Shimaoka. Exosomal regulation of lymphocyte homing to the gut. Blood Advances. 2019. 3. 1. 1-11
Naohiro Seo, Yoshitaka Shirakura, Yoshiro Tahara, Fumiyasu Momose, Naozumi Harada, Hiroaki Ikeda, Kazunari Akiyoshi, Hiroshi Shiku. Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells. Nature Communications. 2018. 9. 1

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MISC (34)：

百瀬文康, 中井貴士, 永春圭規, 山根真妃子, 王立楠, 麻生尚吾, 勝又徹, 下房地剛, 宮原慶裕. HANG Vax drives robust antigen spreading, eradicates target antigen-lost solid tumor and overcomes tumor heterogeneity. 2024
百瀬文康, 中井貴士, 永春圭規, 山根真妃子, 王立楠, 麻生尚吾, 勝又徹, 下房地剛, 宮原慶裕. ヒアルロン酸ナノゲルがんワクチンはAntigen spreadingを介して腫瘍不均一性を克服・打破し得る. 日本がん免疫学会総会プログラム・抄録集 28回. 2024
A novel cancer vaccine based on hyaluronic acid nanogel drives a potent and sustainable antitumor immunity against metastatic- and ICI-resistant-tumors with long lasting memory CD8+ T cells. 2024. 52
百瀬文康, 中井貴士, 藪内昂平, 山根真妃子, 林妙, 中川慶之, 麻生尚吾, 勝又徹, 下房地剛, 宮原慶裕. ヒアルロン酸ナノゲルを用いたがんワクチンのT細胞性免疫を介した抗腫瘍・再発抑制作用. 日本ワクチン学会第64回日本臨床ウイルス学会合同学術集会抄録集. 2023
百瀬文康, 中井貴士, 藪内昂平, 山根真妃子, 林妙, 王立楠, 中川慶之, 麻生尚吾, 勝又徹,下房地剛, 宮原慶裕. Analysis of mechanism of antitumor effect with long lasting memory induced by a novel cancer vaccine based on hyaluronic acid nanogel. 日本癌学会学術総会要旨集 82回. 2023

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Patents (5)：

ヒアルロン酸誘導体、医薬組成物、及び医薬組成物の製造方法
医薬組成物
ヒアルロン酸誘導体、医薬組成物、及び医薬組成物の製造方法
医薬組成物
細胞傷害性T細胞放出エキソソームによる癌間質間葉系細胞を標的とした腫瘍増殖及び転移抑制に係る治療薬

Lectures and oral presentations (38)：

HANG Vax drives robust antigen spreading, eradicates target antigen-lost solid tumor and overcomes tumor heterogeneity
(2024)
ヒアルロン酸ナノゲルがんワクチンはAntigen spreadingを介して腫瘍不均一性を克服・打破し得る
(第28回日本がん免疫学会総会・第37回日本バイオセラピィ学会学術集会総会合同大会 2024)
A novel cancer vaccine based on hyaluronic acid nanogel combined with adoptive T cell therapy induces complete regression of established tumors and long-lasting memory CD8+ T cells
(AACR (American Association for Cancer Research) Annual Meeting 2024 2024)
Engineering Hyaluronic acid-based NPs with enhanced LNs delivery as powerful and versatile priming tool for immunotherapy
(AACR (American Association for Cancer Research) Annual Meeting 2024 2024)
A novel cancer vaccine based on hyaluronic acid nanogel drives a potent and sustainable antitumor immunity against metastatic- and ICI-resistant-tumors with long lasting memory CD8+ T cells
(2024)

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Education (3)：

2012 - 2016 Mie University Graduate School of Medicine
2005 - 2007 Tokyo University of Pharmacy and Life Sciences
2001 - 2005 Tokyo University of Pharmacy and Life Sciences School of Pharmacy School of Pharmacy

Professional career (1)：

博士(医学)

Work history (8)：

2020/04 - 現在 Mie University Graduate School of Medicine Research Assistant Professor
2015/04 - 現在 Mie University
2017/01 - 2020/03 Mie University Graduate School of Medicine
2016/09 - 2016/12 Mie University Graduate School of Medicine
2013/09 - 2016/08 Mie University Hospital

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Awards (5)：

2024/07 - 三重大学生命の駅伝がん研究奨励賞
2023/12 - 三重大学知的財産活用賞
2023/07 - 三重大学生命の駅伝がん研究奨励賞
2016/10 - 三重大学知的財産優秀出願賞
2016/09 - 三重大学学長賞

Association Membership(s) (5)：

日本DDS学会 , 日本ワクチン学会 , 日本免疫学会 , 日本がん免疫学会 , 日本癌学会

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