Mizuno Tadahaya

Mizuno Tadahaya | Mizuno Tadahaya

Affiliation and department：
Job title： assistant professor

Research field (4)： Biological, health, and medical informatics , Clinical pharmacy , Clinical pharmacy , Clinical pharmacy

Research keywords (5)： computational toxicology , representation learning , latent variable model , Cheminformatics , Bioinformatics

Research theme for competitive and other funds (17)：

2023 - 2026 Establishment of a novel experimental system for the comprehensive understanding and quantitative risk assessment of drug-induced intestinal toxicity
2022 - 2025 In situ多層オミクスとリアルワールドデータ活用による口腔がん分子標的探索
2022 - 2025 Development of enzymomics platform for characterization of disease-related alterations of enzymatic activities
2022 - 2024 ニューロンの多階層エピジェネティクス情報の潜在変数モデルによる記憶の解明
2022 - 2024 Mechanism of constituting a cancer cell population resistant to molecular-targeted drugs

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Papers (42)：

Mayano Minoda, Junpei Hatakeyama, Norimichi Nagano, Tadahaya Mizuno, Takumi Iwasaka, Sho Shiga, Kazuki Takahashi, Hideto Hiraide, Shingo Sakamoto, Yu Kagami, et al. Single-Molecule Oxidoreductase Activity Analysis for Activity-Based Diagnosis Based on Proteoform Alterations. Journal of the American Chemical Society. 2025
Koki Kunitake, Tadahaya Mizuno, Kazuki Hattori, Chitose Oneyama, Mako Kamiya, Sadao Ota, Yasuteru Urano, Ryosuke Kojima. Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis and release regulators. Nature Communications. 2024
Iori Azuma, Tadahaya Mizuno, Hiroyuki Kusuhara. GLDADec: marker-gene guided LDA modeling for bulk gene expression deconvolution. Briefings in Bioinformatics. 2024. 25. 4
Tatsuya Ukegawa, Toru Komatsu, Mayano Minoda, Takuya Matsumoto, Takumi Iwasaka, Tadahaya Mizuno, Ryo Tachibana, Shingo Sakamoto, Kenjiro Hanaoka, Hiroyuki Kusuhara, et al. Thioester-Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single-Molecule Enzyme Activities of Esterases with Specified Substrate Recognition. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024. 11. 10. e2306559
Yasuhiro Yoshikai, Tadahaya Mizuno, Shumpei Nemoto, Hiroyuki Kusuhara. Difficulty in chirality recognition for Transformer architectures learning chemical structures from string representations. Nature Communications. 2024. 15. 1. 1197-1197

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MISC (5)：

Nakajima Yoko, Osaka Shuhei, Mizuno Tadahaya, Yokoi Katsuyuki, Nakano Satoshi, Hirai Saeko, Suzuki Mitsuyoshi, Kusuhara Hiroyuki, Hayashi Hisamiysu. Influence of food on pharmacokinetics of 4-phenylbutyrate in patients with urea cycle disorders(和訳中). 日本先天代謝異常学会雑誌. 2021. 37. 160-160
三宅健之, 水野忠快, 望月達貴, 木村美由紀, 松木俊二, 入江伸, 家入一郎, 前田和哉, 楠原洋之. 腎有機カチオントランスポーターOCT2の機能低下を診断するバイオマーカーの探索. 臨床薬理. 2017. 48. Suppl. S340-S340
森大輝, 石田博雄, 水野忠快, 藤田健一, 楠本壮二郎, 前田和哉, 佐々木康綱, 楠原洋之. 内在性基質をプローブとした抗がん剤パクリタキセルによるOATP1B阻害の検出. 臨床薬理. 2017. 48. Suppl. S342-S342
Kensuke Aida, Hisamitsu Hayashi, Kaori Inamura, Tadahaya Mizuno, Yuichi Sugiyama. UBIQUITINATION IS ASSOCIATED WITH THE INTERNALIZATION OF BILE SALT EXPORT PUMP (BSEP/ABCB11) FROM THE PLASMA MEMBRANE. HEPATOLOGY. 2011. 54. 725A-726A
Tadahaya Mizuno, Hisamitsu Hayashi, Yuichi Sugiyama. Ubiquitination Is Associated With Degradation of ATP-binding Cassette Transporter A1 (ABCA1) On Cell Surface. DRUG METABOLISM REVIEWS. 2010. 42. 308-309

Lectures and oral presentations (23)：

毒性学を志向した言語モデルによる潜在表現抽出
(第7回医薬品毒性機序研究部会 2025)
化合物作用の理解に向けた恣意性のない数値化とパターン認識
(CBI学会2024年大会 2024)
AI-based Feature Generation for Molecular Design
(26th North American ISSX and 39th JSSX Meeting 2024)
低分子化合物の潜在表現を抽出するモデリング
(第51回日本毒性学会学術年会 2024)
薬物の作用の包括的言語化に向けた研究基盤の構築
(日本薬学会第144年会 2024)

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Education (3)：

2009 - 2014 The University of Tokyo Laboratory of Molecular Pharmacokinetics Graduate School of Pharmaceutical Sciences
2005 - 2009 The University of Tokyo Faculty of Pharmaceutical Sciences
2002 - 2005 神奈川県立柏陽高校

Work history (1)：

2014/04 - 現在 The University of Tokyo Laboratory of Molecular Pharmacokinetics Graduate School of Pharmaceutical Sciences

Committee career (1)：

Awards (5)：

Association Membership(s) (6)：

日本動物実験代替法学会 , 日本薬学会 , International Society for the Study of Xenobiotics , 情報計算化学生物学会 (CBI学会) , 日本薬物動態学会 , 日本毒性学会

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