Hoshino Shotaro

ホシノショウタロウ | Hoshino Shotaro

Affiliation and department：
Job title： Assistant professor

Research field (4)： Environmental and pharmaceutical development resources , Applied biochemistry , Bioorganic chemistry , Applied microbiology

Research keywords (5)： Anibiotics , Actinobacteria , Biosynthesis , Secondary metabolism , Natural product

Research theme for competitive and other funds (4)：

2023 - 2025 新規炭素-ヒ素結合形成反応を基盤とした未開拓天然物生合成経路の集積
2022 - 2024 放線菌におけるヒ素二次代謝経路の開拓及び新規ヒ素二次代謝産物の探索研究
2019 - 2021 Activation of cryptic biosynthetic gene clusters in actinomycetes using high-thr oughput elicitor screening
2016 - 2019 Investigation for ComX pheromone-like molecules in Streptomyces bacteria

Papers (38)：

Nhat Nam Hoang, Shotaro Hoshino, Takeshi Kodama, Yu Nakashima, Kiep Minh Do, Hoang Xuan Thao, Naotaka Ikumi, Hiroyasu Onaka, Hiroyuki Morita. Three neo-Clerodane Diterpenoids from Tinospora cordifolia Stems and Their Arginase Inhibitory Activities. Chemical and Pharmaceutical Bulletin. 2024. 72. 6. 540-546
Kiep Minh Do, Shotaro Hoshino, Takeshi Kodama, Hien Minh Nguyen, Son Van Le, Naotaka Ikumi, Hiroyasu Onaka, Hiroyuki Morita. A new 3,4-seco-isopimarane and three new isopimarane diterpenoids from Kaempferia champasakensis collected from Vietnam and their cytotoxic activities. Journal of Natural Medicines. 2024
Shotaro Hoshino, Shinta Ijichi, Shumpei Asamizu, Hiroyasu Onaka. Insights into Arsenic Secondary Metabolism in Actinomycetes from the Structure and Biosynthesis of Bisenarsan. Journal of the American Chemical Society. 2023
Shinta Ijichi, Shotaro Hoshino, Shumpei Asamizu, Hiroyasu Onaka. SolS-catalyzed sulfoxidation of labionin to solabionin drives antibacterial activity of solabiomycins. Bioorganic & medicinal chemistry letters. 2023. 129323-129323
Esther J. Han, Seoung Rak Lee, Shotaro Hoshino, Mohammad R. Seyedsayamdost. Targeted Discovery of Cryptic Metabolites with Antiproliferative Activity. ACS Chemical Biology. 2022

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MISC (30)：

Shotaro Hoshino, Hiroyasu Onaka. No Title. BIOSCIENCE & INDUSTRY. 2024. 82. 3. 296-298
伊地知新太, 星野翔太郎, 浅水俊平, 浅水俊平, 尾仲宏康, 尾仲宏康. Analysis of oxidoreductase responsible for the formation of a new solabionin scaffold. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
星野翔太郎, 浅水俊平, 浅水俊平, 尾仲宏康, 尾仲宏康. Studies on arsenic-related secondary metabolism in actinobacteria. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
星野翔太郎, 浅水俊平, 尾仲宏康. Exploration of arsenic secondary metabolic pathways distributed in actinomycetes. 日本放線菌学会大会講演要旨集. 2023. 37th
伊地知新太, 星野翔太郎, 浅水俊平, 尾仲宏康. Sulfoxidation of labionin enhances antibacterial activity. 日本放線菌学会大会講演要旨集. 2023. 37th

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Lectures and oral presentations (35)：

Organoarsenic-related secondary metabolic pathway found in actinomycetes
(1st Japan-Korea Actinomycetes Symposium 2024)
Actinomycetes expand the field of organoarsenic natural products
(The 144th Annual Meeting of the Pharmaceutical Society of Japan (Yokohama) 2024)
Accumulation of unexplored natural product biosynthetic pathway based on novel C-As bond forming reaction
(2024)
Actinomycetes expand the diversity of organoarsenic natural products
(2023 The 1st Taiwan-Japan Bilateral Symposium on Natural Products Biosynthesis 2023)
Studies on arsenic-related secondary metabolism in actinobacteria
(2023)

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Education (4)：

2016 - 2019 The University of Tokyo Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Sciences
2014 - 2016 The University of Tokyo Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Sciences
2012 - 2014 The University of Tokyo Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
2010 - 2012 The University of Tokyo College of Arts and Sciences Natural Science I

Professional career (1)：

Ph.D. (Pharmaceutical Science) (The University of Tokyo)

Work history (6)：

2023/04 - 現在 Gakushuin University Faculty of Science Department of Life Science Assistant professor
2022/04 - 2023/03 The University of Tokyo Graduate School of Agricultural and Life Sciences Project Assistant Professor
2021/12 - 2022/02 Princeton University Department of Chemistry Postdoctoral Researcher
2019/06 - 2021/11 JSPS Postdoctral Fellowship for Research Abroad Princeton University Department of Chemistry Postdoctoral Researcher
2019/04 - 2019/05 The University of Tokyo Graduate School of Pharmaceutical Sciences Reserch Fellow

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Awards (10)：

2023/06 - The Pharmaceutical Society of Japan Division of Natural Medicines Incentive Research in 2023 Exploiting untapped secondary metabolic pathways in actinomycetes to discover novel natural products
2023/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA) Hot Topics Award at Annual Meeting of JSBBA 2023 Studies on arsenic-related secondary metabolism in actinobacteria
2022/09 - The Society for Actinomycetes Japan 2022 Poster Presentation Award Studies on organo-arsenic secondary metabolites produced by actinobacteria
2018/04 - 日本薬学会日本薬学会第138年会優秀発表賞『複合培養法を利用した希少放線菌からの生物活性物質探索』
2017/10 - 日本薬学会生薬天然物部会第7回食品薬学シンポジウム優秀発表賞『複合培養法を用いた希少放線菌からの医薬品資源探索』

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Association Membership(s) (4)：

The Pharmaceutical Society of Japan , The Japanese Society of Pharmacognosy , Society for Actinomycetes Japan , Japan Society for Bioscience, Biotechnology, and Agrochemistry

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