Sugiyama Hirokazu

スギヤマヒロカズ | Sugiyama Hirokazu

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://www.pse.t.u-tokyo.ac.jp/Sugiyama/index.html

Research field (1)： Chemical reaction and process system engineering

Research keywords (3)： Pharma , Process System Engineering , Chemical Engineering

Research theme for competitive and other funds (8)：

2021 - 2025 Development of rapid manufacturing support system for anti-pandemic drugs
2021 - 2024 Development of innovative management strategy for pharmaceutical continuous manufacturing processes
2020 - 2023 Multiscale design platform for innovating freezing processes of iPS cells
2017 - 2021 Development of innovative process design methodology for pharmaceutical manufacturing and tool implementation
2015 - 2018 Safety design method of Lithium ion battery using systems approach

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Papers (100)：

Kozue Okamura, Kota Oishi, Sara Badr, Akira Yamada, Hirokazu Sugiyama. Data-driven parameterization and development of mechanistic cell cultivation models in monoclonal antibody production processes: Shifts in cell metabolic behavior. Computers & Chemical Engineering. 2024. 191. 108822-108822
Kosuke Nemoto, Yusuke Hayashi, Hirokazu Sugiyama. Indicator-based assessment of potential supply risks for pharmaceutical excipients: Method and application. International Journal of Pharmaceutics. 2024. 663. 124498-124498
Benedikt X. Scholz, Yusuke Hayashi, Yuka Higashi, Yuki Uno, Mohamed Rami Gaddem, Masahiro Kino-oka, Hirokazu Sugiyama. Computational fluid dynamics model-based design of continuous forced convection freezing processes for human induced pluripotent stem cells considering supercooling of extracellular solutions. Chemical Engineering Research and Design. 2024. 208. 674-682
Kozue Okamura, Sara Badr, Yusuke Ichida, Akira Yamada, Hirokazu Sugiyama. Modeling of cell cultivation for monoclonal antibody production processes considering lactate metabolic shifts. Biotechnology Progress. 2024. 3486
Mohamed Rami Gaddem, Junu Kim, Kensaku Matsunami, Yusuke Hayashi, Sara Badr, Hirokazu Sugiyama. Roles of mechanistic, data-driven, and hybrid modeling approaches for pharmaceutical process design and operation. Current Opinion in Chemical Engineering. 2024. 44. 101019-101019

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MISC (106)：

石本隼人, 加納学, 小出達夫, 下野龍太郎, 杉山弘和, 高垣恵介, 高山一成, 谷村真爾, 中山幸治, 水丸智絵, et al. 医薬品経口固形製剤の連続生産における多変量統計的プロセス管理の活用事例CTDモックアップ. 日本PDA学術誌GMPとバリデーション. 2024. 26. 1. 30-52
杉山弘和, Badr Sara, 林勇佑. 医薬品製造プロセス設計・運転のためのデジタル技術. 製剤機械技術学会誌133号. 2024. 33. 3. 45-52
Yusuke Hayashi, Benedikt X. Scholz, Hirokazu Sugiyama. A CFD-model-based approach to continuous freezing process design for human induced pluripotent stem cells. Computer Aided Chemical Engineering. 2023. 65-70
杉山弘和, 岡村梢, Badr Sara. 次世代抗体医薬の実用化に向けた生産技術開発:抗体医薬品製造プロセスのハイブリッド・モデリング. 生物工学会誌. 2023. 101. 6
Sara Badr, Kota Oishi, Kozue Okamura, Sei Murakami, Hirokazu Sugiyama. Hybrid modelling and data-driven parameterization of monoclonal antibody cultivation processes: Shifts in cell metabolic behavior. Computer Aided Chemical Engineering. 2023. 985-990

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Books (5)：

Optimization of Pharmaceutical Processes
Springer Optimization and Its Applications 2022
フロー合成、連続生産のプロセス設計、条件設定と応用事例
技術情報協会 2020 ISBN:9784861048203
Continuous Manufacturing of Solid Pharmaceutical Preparations and Biopharmaceutical Drug Substance
2019
注射剤製造における無菌性保証・バリデーションと異物低減ノウハウ・検査事例
サイエンス&テクノロジー 2016
抗体医薬品における細胞構築・培養・ダウンストリームのすべて
2015

Lectures and oral presentations (123)：

原薬フロー合成プロセスのデジタル設計
(日本プロセス化学会2024サマーシンポジウム 2024)
Hybrid-modeling approaches for the design and operation of pharmaceutical processes
(The 3rd PSE state-of-the-art Workshop,Hangzhou Jinxi Hotel, Hangzhou, China)
固形製剤連続生産プロセスシステム工学の視点から
(立命館大学創剤・製剤技術研究コンソーシアム第3回研究会(オンライン) 2023)
プロセス設計のためのモデル化・シミュレーション・最適化技術
(バイオジャパン・主催者セミナー「バイオ医薬分野における製品・プロセスのデジタル開発」 2023)
低分子・抗体・幹細胞製造プロセスのデジタル設計
(第22回メルクバイオフォーラム2023 2023)

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Works (2)：

SoliDecision
Kensaku Matsunami, Fabian Sternal, Keita Yaginuma, Shuichi Tanabe, Hiroshi Nakagawa, Hirokazu Sugiyama 2020 - 現在
TECHoice
Haruku Shirahata, Sara Badr, Yuki Shinno, Shuta Hagimori, Hirokazu Sugiyama 2019 - 現在

Education (2)：

2003 - 2007 ETH Zurich Institute for Chemical and Bioengineering
2001 - 2003 The University of Tokyo The Graduate School of Engineering Department of Chemical System Engineering

Professional career (1)：

Ph.D. (ETH Zurich)

Work history (3)：

2021/04 - 現在 The University of Tokyo The Graduate School of Engineering Department of Chemical System Engineering Professor
2013/02 - 2021/03 The University of Tokyo The Graduate School of Engineering Department of Chemical System Engineering Associate Professor
2007 - 2013 F. Hoffmann-La Roche

Committee career (5)：

- 現在化学工学会理事
- 現在 International Society for Pharmaceutical Engineering, Inc. Japan Affiliate Adjunct Director
- 現在日本学術振興会プロセスシステム工学第143委員会幹事
- 現在化学工学会システム・情報・シミュレーション部会副部会長
Journal of Chemical Engineering of Japan Editor

Awards (13)：

2024/09 - 化学工学会 SIS部会技術賞
2023/12 - Industrial & Engineering Chemistry Research 2023 Class of Influential Researchers - Asia and Pacific
2023/09 - 化学工学会 SIS部会技術賞 CFD-based modeling of a continuous forced convection-based freezer unit for human induced pluripotent stem cells considering supercooling
2023/01 - 東京大学大学院工学系研究科工学系研究科長表彰(研究部門)
2022/07 - (一財)バイオインダストリー協会第6回「バイオインダストリー奨励賞」抗体・幹細胞製造プロセスのデジタル設計を支援するシミュレーション技術

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Association Membership(s) (8)：

日本薬剤学会 , バイオインダストリー協会 , PDA (Parenterals Drug Association) , ISPE (International Society for Pharmaceutical Engineering) , AIChE (American Institute of Chemical Engineers) , The Institute of Life Cycle Assessment, Japan , Society of Chemical Engineering of Japan , ACS (American Chemistry Society)

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