Sohma Youhei

ソウマヨウヘイ | Sohma Youhei

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://www.wakayama-med.ac.jp/pharm/yakuhinkagaku/

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (5)：生物有機化学 , ペプチド , タンパク質 , 神経変性疾患 , アミロイド

Research theme for competitive and other funds (5)：

2021 - 2024 神経変性疾患の原因アミロイドタンパク質に対する革新的凝集阻害戦略の開発
2019 - 2021 Control of intracellular amyloid dynamics using photooxygenation catalysts
2016 - 2020 Development of aggregation inhibition strategy for pathogenic amyloid proteins
2009 - 2012 Design and Medicinal Chemistry Research on Therapeutics ofDifficult Diseases based on Molecular Recognition
2010 - 2011 Research on pathological mechanism of amyloid beta peptide and application to the aggregation inhibitor

Papers (33)：

Reito Nakamura, Ikumi Tomizawa, Atsushi Iwai, Tetsuo Ikeda, Kota Hirayama, Yung Wen Chiu, Takanobu Suzuki, Airi Tarutani, Tatsuo Mano, Atsushi Iwata, et al. Photo-oxygenation of histidine residue inhibits α-synuclein aggregation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023. 37. 12. e23311
Hiroki Umeda, Taka Sawazaki, Masahiro Furuta, Takanobu Suzuki, Shigehiro A Kawashima, Harunobu Mitsunuma, Yukiko Hori, Taisuke Tomita, Youhei Sohma, Motomu Kanai. Quantitative Assays for Catalytic Photo-Oxygenation of Alzheimer Disease-Related Tau Proteins. ACS chemical neuroscience. 2023. 14. 15. 2710-2716
Atsushi Iwai, Reito Nakamura, Ikumi Tomizawa, Harunobu Mitsunuma, Yukiko Hori, Taisuke Tomita, Youhei Sohma, Motomu Kanai. Attenuation of α-synuclein aggregation by catalytic photo-oxygenation. Chemical communications (Cambridge, England). 2023. 59. 38. 5745-5748
Joaquim Torra, Taka Sawazaki, Patricia Bondia, Santi Nonell, Motomu Kanai, Youhei Sohma, Cristina Flors. Activatable iodinated BODIPYs for selective imaging and photodynamic disruption of amyloid structures in pathogenic bacterial biofilms. Sensors and Actuators B: Chemical. 2022. 371. 132475-132475
Yukiko Hori, Youhei Sohma, Motomu Kanai, Taisuke Tomita. Promotion in the Clearance of Aggregated Aβ In Vivo Using Amyloid Selective Photo-Oxygenation Technology. Neuroscience insights. 2022. 17. 26331055221126179-26331055221126179

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MISC (18)：

浅井秀一朗, 渡邉謙一, 相馬洋平, 金井求, 堀由起子, 富田泰輔. AAアミロイドーシス治療を目指した光酸素化法の検証. 日本アミロイドーシス学会学術集会プログラム・抄録集. 2023. 10th
栗山摩衣, 鈴木崇允, 澤崎鷹, 澤崎鷹, 相馬洋平, 相馬洋平, 金井求, 堀由起子, 富田泰輔. 細胞内凝集タウに対する光酸素化の薬効の評価. Dementia Japan. 2023. 37. 4
中川葉奈子, 鈴木崇允, 澤崎鷹, 澤崎鷹, 相馬洋平, 相馬洋平, 金井求, 堀由起子, 富田泰輔. Elucidation of mechanism of the aggregated tau clearance by photo-oxygenation. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
古田将大, 堀由起子, 富田泰輔, 相馬洋平, 三ツ沼治信, 三ツ沼治信, 金井求. Development of highly active photooxygenation catalysts for amyloids toward in-vivo applications. 日本薬学会年会要旨集(Web). 2023. 143rd
渥美渉, 川畑恵一, 山根三奈, 大井未来, 三ツ沼治信, 堀由起子, 富田泰輔, 相馬洋平, 金井求. Development of ultradound-mediated Amyloid β oxygenation catalyst toward clinical applications. 日本薬学会年会要旨集(Web). 2023. 143rd

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Patents (5)：

Education (1)：

Professional career (1)：

Work history (5)：

Committee career (1)：

Awards (6)：

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Association Membership(s) (4)：

日本ケミカルバイオロジー学会 , 日本ペプチド学会 , 日本化学会 , 日本薬学会

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