Rchr
J-GLOBAL ID:202201005248398640   Update date: Feb. 01, 2024

Fujii Takuto

フジイ タクト | Fujii Takuto
Affiliation and department:
Job title: Assistant Professor
Research field  (6): Physiology ,  Pharmacology ,  Biophysics ,  Cell biology ,  Molecular biology ,  Tumor biology
Research keywords  (10): 分子生理学 ,  膜輸送 ,  細胞生理学 ,  イオンポンプ ,  H+,K+-ATPase ,  Na+,K+-ATPase ,  トランスポーター ,  イオンチャネル ,  胃酸 ,  がん
Research theme for competitive and other funds  (9):
  • 2022 - 2025 Regulatory mechanisms of the cancer cell survival triggered by intracellular sodium pump present in the vesicles
  • 2022 - 2025 消化器癌における血中循環腫瘍細胞のクラスター化阻害に着目した新規治療開発
  • 2020 - 2023 Regulatory mechanism of calcium signaling in endoplasmic reticulum by novel K+ pump
  • 2017 - 2020 Physiological and pathophysiological properties of Parkinson's disease-related cation pump ATP13A2
  • 2014 - 2017 Novel anti-cancer mechanism of the targeting of the association between receptor-type sodium pump and VSOR channels
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Papers (41):
  • Takuto Fujii, Shushi Nagamori, Pattama Wiriyasermkul, Shizhou Zheng, Asaka Yago, Takahiro Shimizu, Yoshiaki Tabuchi, Tomoyuki Okumura, Tsutomu Fujii, Hiroshi Takeshima, et al. Parkinson's disease-associated ATP13A2/PARK9 functions as a lysosomal H+,K+-ATPase. Nature communications. 2023. 14. 1. 2174-2174
  • Takuto Fujii, Mizuki Katoh, Manami Ootsubo, Oanh T T Nguyen, Mayumi Iguchi, Takahiro Shimizu, Yoshiaki Tabuchi, Yasuharu Shimizu, Hiroshi Takeshima, Hideki Sakai. Cardiac glycosides stimulate endocytosis of GLUT1 via intracellular Na+ ,K+ -ATPase α3-isoform in human cancer cells. Journal of cellular physiology. 2022. 237. 7. 2980-2991
  • Takahiro Shimizu, Nobuhiro Yanase, Takuto Fujii, Haruka Sakakibara, Hideki Sakai. Regulation of TRPV1 channel activities by intracellular ATP in the absence of capsaicin. Biochimica et biophysica acta. Biomembranes. 2022. 1864. 1. 183782-183782
  • Takuto Fujii, Kenji Sugimoto, Takafumi Noda, Takahiro Shimizu, Yuji Matsuya, Hideki Sakai. Inhibition of gastric H+,K+-ATPase by new dihydropyrazole derivative KYY-008. Biochemical and biophysical research communications. 2021. 567. 177-182
  • Takuto Fujii, Takahiro Shimizu, Mizuki Katoh, Shushi Nagamori, Keiichi Koizumi, Junya Fukuoka, Yoshiaki Tabuchi, Akira Sawaguchi, Tomoyuki Okumura, Kazuto Shibuya, et al. Survival of detached cancer cells is regulated by movement of intracellular Na+,K+-ATPase. iScience. 2021. 24. 5. 102412-102412
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MISC (8):
  • Taiga Higuchi, Takahiro Shimizu, Takuto Fujii, Noriaki Takeguchi, Bernd Nilius, Hideki Sakai. Modulation of TRPP3 channel function by increasing temperature. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S196-S196
  • Takahiro Shimizu, Yuta Takahashi, Takuto Fujii, Noriaki Takeguchi, Hideki Sakai. The role of Kv7.1 K+ channels in thromboxane A(2)-induced cell proliferation of human colonic cancer cells. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S198-S198
  • Takuto Fujii, Yuji Takahashi, Kyosuke Fujita, Takahiro Shimizu, Noriaki Takeguchi, Hideki Sakai. Chloride-proton antiporter ClC-5 is functionally associated with gastric proton pump. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S218-S218
  • Takuto Fujii, Kazuto Shibuya, Eri Shimoda, Takahiro Shimizu, Noriaki Takeguchi, Kazuhiro Tsukada, Hideki Sakai. Properties of ouabain-insensitive Na+-ATPase activity in human liver cells. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2010. 60. S106-S106
  • Kyosuke Fujita, Takahiro Shimizu, Takuto Fujii, Noriaki Takeguchi, Hideki Sakai. The role of Cl- on membrane potentials in parietal cells of mechanically isolated mouse gastric glands. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2010. 60. S81-S81
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