Nagata Mizuki

ナガタミズキ | Nagata Mizuki

Affiliation and department：
Job title： Assistant Professor

Research field (2)： Developmental biology , Conservative dentistry and endodontics

Research keywords (6)： Single-cell RNA sequencing analysis , Genetic Lineage Tracing , Tooth Development , Periodontal Ligament , Periodontal Regeneration , Mesenchymal Stem Cell

Research theme for competitive and other funds (4)：

2023 - 細胞系譜追跡とシングルセル解析による歯根尖部幹細胞の分化制御機構の解明
2022 - ヘッジホッグシグナルによる歯周組織形成および再生機構の解明
2021 - シングルセル解析とトランスジェニックマウスを駆使した歯周組織形成・再生機構の解明
2019 - Cxcl12陽性歯乳頭由来幹細胞のin vivoにおける細胞運命と分化制御機構の解明

Papers (25)：

Xiao-xia Li, Man-ting Wang, Zhi-fang Wu, Qiang Sun, Noriaki Ono, Mizuki Nagata, Xiao-long Zang, Wanida Ono. Etiological Mechanisms and Genetic/Biological Modulation Related to PTH1R in Primary Failure of Tooth Eruption. Calcified Tissue International. 2024. 115. 2. 101-116
Yuki Matsushita, Hiroaki Manabe, Takahiro Ohyama, Shogo Nakamura, Mizuki Nagata, Wanida Ono, Noriaki Ono. Hes1 marks peri-condensation mesenchymal cells that generate both chondrocytes and perichondrial cells in early bone development. Journal of Biological Chemistry. 2023. 104805-104805
Yuki Matsushita, Jialin Liu, Angel Ka Yan Chu, Chiaki Tsutsumi-Arai, Mizuki Nagata, Yuki Arai, Wanida Ono, Kouhei Yamamoto, Thomas L. Saunders, Joshua D. Welch, et al. Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis. Nature Communications. 2023. 14. 1
Yuki Matsushita, Angel Ka Yan Chu, Chiaki Tsutsumi-Arai, Shion Orikasa, Mizuki Nagata, Sunny Y. Wong, Joshua D. Welch, Wanida Ono, Noriaki Ono. The fate of early perichondrial cells in developing bones. Nature Communications. 2022. 13. 1
Mizuki Nagata, Jeryl D. English, Noriaki Ono, Wanida Ono. Diverse stem cells for periodontal tissue formation and regeneration. genesis. 2022

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MISC (5)：

Mizuhashi K, Nagata M, Matsushita Y, Ono W, Ono N. Growth plate borderline chondrocytes behave as transient mesenchymal precursor cells. Yearbook of Paediatric Endocrinology. 2020
Nishimori S, OMeara MJ, Castro CD, Noda H, Cetinbas M, da Silva Martins J, Ayturk U, Brooks DJ, Bruce M, Nagata M, et al. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodelling. Yearbook of Paediatric Endocrinology. 2020
Yuki Matsushita, Mizuki Nagata, Joshua D. Welch, Sunny Y. Wong, Wanida Ono, Noriaki Ono. Notch effector Hes1 marks an early perichondrial population of skeletal progenitor cells at the onset of endochondral bone development. 2020
永田睦, 永田瑞. “セメント質剥離と歯周病”アップデート歴史的背景から日常臨床の対応まで. DENTAL DIAMOND. 2019
永田睦, 永田瑞. 超高齢社会とセメント質剥離. DENTAL DIAMOND. 2018

Books (3)：

非外科治療による歯周病コントロール : 歯科医師・歯科衛生士のためのClinical handbook
医歯薬出版 2018 ISBN:9784263445280
歯周外科の基本テクニック術前検査からメインテナンスまで
医歯薬出版株式会社 2017
ITI Treatment Guide Vol.6 審美領域における複数歯欠損
クインテッセンス出版 2013 ISBN:9784781203256

Lectures and oral presentations (11)：

Wnt-directed CXCL12-expressing apical papilla mesenchymal progenitor cells drive tooth root formation
(The 2024 Rolanette and Berdon Lawrence Bone Disease Program of Texas, Bone Research Conference 2024)
Wnt-directed CXCL12-expressing apical papilla mesenchymal progenitor cells drive tooth root formation
(2024)
The mesenchymal cells derived from dental follicle contribute to periodontal regeneration
(University of Texas Health Science Center at Houston School of Dentistry Annual Research Showcase 2023)
Dental Follicle Regulates Periodontium Formation via a Hedgehog-Dependent Mechanism
(American Association for Dental, Oral & Craniofacial Research (AADOCR) Annual Meeting 2023)
Single-cell Transcriptomic Analysis Reveals Developmental Relationships and Specific Markers of Mouse Periodontium Cellular Subsets
(3rd Annual GCC Single Cell Omics Symposium 2022)

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Education (2)：

2013 - 2017 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Department of Periodontology
2005 - 2012 Tokyo Medical and Dental University Faculty of Dentistry School of Dentistry

Work history (6)：

2024/07 - 現在 Tokyo Medical and Dental University Department of Periodontology Assistant Professor
2022/04 - 2024/06 Tokyo Medical and Dental University
2021/07 - 2024/06 University of Texas Health Science Center at Houston School of Dentistry Department of Orthodontics Postdoctoral Research Fellow
2021/04 - 2023/03 Japan Society for the Promotion of Science
2018/01 - 2021/06 Univerisity of Michigan School of Dentistry Department of Orthodontics & Pediatric Dentistry Postdoctoral Research Fellow

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Awards (11)：

2024/04 - Best Poster Award for the Postdoc Category, The 2024 Rolanette and Berdon Lawrence Bone Disease Program of Texas, Bone Research Conference
2024/01 - Travel Award for an Selected Abstract,Gordon Research Conference, Bone and Teeth
2023/10 - University of Texas Health Science Center at Houston School of Dentistry Annual Research Showcase Best Poster Award for the Category of Postdoctoral Research Fellows The mesenchymal cells derived from dental follicle contribute to periodontal regeneration
2023/03 - American Association for Dental, Oral, Craniofacial Research (AADOCR) Finalist of Joseph Lister Award Competition for New Investigators Dental Follicle Regulates Periodontium Formation via a Hedgehog-dependent mechanism
2022/10 - 日本学術振興会卓越研究員候補者

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Association Membership(s) (4)：

International Association for Dental Research (IADR) , 日本口腔インプラント学会 , 日本歯科保存学会 , 日本歯周病学会

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