Rchr
J-GLOBAL ID：202201005620287051
Update date: Jun. 24, 2024
Machitani Mitsuhiro
マチタニ ミツヒロ | Machitani Mitsuhiro
Affiliation and department：
Job title：
Laboratory Head
Research field (3)：
Virology
, Tumor biology
, Molecular biology
Research theme for competitive and other funds (3)：
- 2022 - 2024 テロメラーゼ逆転写酵素による遺伝子発現制御が標的とする新規遺伝子の同定
- 2020 - 2022 Study about the innate immune response against double-stranded RNAs in cancer cells
- 2015 - 2017 ウイルス遺伝子の非特異的な発現を抑制可能な次世代アデノウイルスベクターの作製
Papers (24)：
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Mitsuhiro Machitani, Akira Nomura, Taro Yamashita, Mami Yasukawa, Saori Ueki, Ken-Ichi Fujita, Toshihide Ueno, Akio Yamashita, Yoshikazu Tanzawa, Masahiko Watanabe, et al. Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity. Nature cell biology. 2024
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Mitsuhiro Machitani, Junko Takei, Mika K Kaneko, Saori Ueki, Hirofumi Ohashi, Koichi Watashi, Yukinari Kato, Kenkichi Masutomi. Development of novel monoclonal antibodies against nsp12 of SARS-CoV-2. Virology journal. 2022. 19. 1. 213-213
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Yoko Matsuda, Taro Yamashita, Juanjuan Ye, Mami Yasukawa, Keiko Yamakawa, Yuri Mukai, Mitsuhiro Machitani, Yataro Daigo, Yohei Miyagi, Tomoyuki Yokose, et al. Phosphorylation of hTERT at threonine 249 is a novel tumor biomarker of aggressive cancer with poor prognosis in multiple organs. The Journal of pathology. 2022. 257. 2. 172-185
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Mitsuhiro Machitani, Ichiro Taniguchi, Asako McCloskey, Tatsuya Suzuki, Mutsuhito Ohno. The RNA transport factor PHAX is required for proper histone H2AX expression and DNA damage response. RNA (New York, N.Y.). 2020. 26. 11. 1716-1725
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Mitsuhiro Machitani, Mami Yasukawa, Jotaro Nakashima, Yasuhiro Furuichi, Kenkichi Masutomi. RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID-19. Cancer science. 2020. 111. 11. 3976-3984
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MISC (4)：
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K. Wakabayashi, M. Machitani, M. Tachibana, F. Sakurai, H. Mizuguchi. Small RNA derived from Adenovirus Virus-Associated RNA II, mivaRNA II, promotes Ad replication via post-transcriptional gene silencing. HUMAN GENE THERAPY. 2016. 27. 11. A174-A174
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K. Tomita, F. Sakurai, M. Machitani, M. Tachibana, H. Mizuguchi. Effects of antibodies against adenoviral capsid proteins on adenovirus vector-mediated in vivo transduction. HUMAN GENE THERAPY. 2016. 27. 11. A148-A148
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Mitsuhiro Machitani, Kazufumi Katayama, Fuminori Sakurai, Hayato Matsui, Tomoko Yamaguchi, Takayuki Suzuki, Hiroyuki Miyoshi, Kenji Kawabata, Hiroyuki Mizuguchi. DEVELOPMENT OF AN ADENOVIRUS VECTOR LACKING THE VIRUS-ASSOCIATED RNA EXPRESSION. JOURNAL OF GENE MEDICINE. 2014. 16. 7-8. 234-235
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Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi. Evaluation of Involvement of microRNA Processing Factors in Adenovirus Replication. MOLECULAR THERAPY. 2014. 22. S32-S32
Books (1)：
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今、着実に実り始めた遺伝子治療 : 最新研究と今後の展開(担当: 第2章 3)
メディカルドゥ 2016 ISBN:9784944157600
Professional career (1)：
Work history (5)：
- 2024/06 - 現在 国立がん研究センター研究所, がん幹細胞研究分野, ユニット長
- 2019/04 - 2024/05 国立がん研究センター研究所 がん幹細胞研究分野 研究員(常勤)
- 2016/04 - 2019/03 京都大学ウイルス・再生医科学研究所 RNAシステム分野 日本学術振興会特別研究員PD
- 2015/04 - 2016/03 大阪大学大学院薬学研究科 分子生物学分野 特任研究員
- 2012/04 - 2015/03 大阪大学大学院薬学研究科 分子生物学分野 日本学術振興会特別研究員DC1
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