Hamada Motoharu

Research field (2)： Hematology and oncology , Fetal medicine/Pediatrics

Research keywords (8)： pediatric hematology , pediatric oncology , inherited bone marrow failure syndrome , Formaldehyde , acute lymphoblastic leukemia , Minimal residual disease , chimeric antigen receptor T cell , stem cell transplantation

Research theme for competitive and other funds (4)：

2021 - 2122 小児急性リンパ性白血病に対するキメラ抗原受容体T細胞療法後の次世代シーケンサーを用いた微小残存病変(NGS-MRD)解析による個別化医療の開発
2021 - 2024 GD2陽性固形腫瘍に対する非ウイルスベクターを用いたキメラ抗原受容体T細胞製剤の開発
2021 - 2024 アルデヒド代謝異常により発症するAMeD症候群の分子病態解明
2020 - 2023 遺伝性骨髄不全症候群の新規原因遺伝子探求を目的とした網羅的遺伝子解析

Papers (52)：

Manabu Wakamatsu, Hideki Muramatsu, Hironori Sato, Masaki Ishikawa, Ryo Konno, Daisuke Nakajima, Motoharu Hamada, Yusuke Okuno, Yusuke Kawashima, Asahito Hama, et al. Integrated proteogenomic analysis for inherited bone marrow failure syndrome. Leukemia. 2024
濱田太立, 村松秀城. 【造血器疾患の遺伝子異常】遺伝性骨髄不全症候群における遺伝子異常. 血液内科. 2024. 88. 5. 491-497
Seiichi Kato, Motoharu Hamada, Akinao Okamoto, Daisuke Yamashita, Hiroaki Miyoshi, Haruto Arai, Akira Satou, Yuka Gion, Yasuharu Sato, Yuta Tsuyuki, et al. EBV+ nodal T/NK-cell lymphoma associated with clonal hematopoiesis and structural variations of the viral genome. Blood Advances. 2024. 8. 9. 2138-2147
Tomoko Fujikawa, Suguru Uemura, Daiichiro Hasegawa, Naoya Morisada, Sayaka Nakamura, Aiko Kozaki, Atsuro Saito, Kenji Kishimoto, Toshiaki Ishida, Takeshi Mori, et al. Novel mutation in <i>KIF23</i> causing congenital dyserythropoietic anemia type III in patients who underwent allogeneic hematopoietic stem cell transplantation. Pediatric Blood & Cancer. 2024. 71. 6
Mari Kagajo, Kyoko Moritani, Mayumi Iwamoto, Machiko Miyamoto, Tsuyoshi Imai, Motoharu Hamada, Manabu Wakamatsu, Hideki Muramatsu, Minenori Eguchi-Ishimae, Mariko Eguchi. Two cases of AMeD syndrome with isochromosome 1q treated with allogeneic stem cell transplantation. Leukemia Research Reports. 2024. 22. 100476-100476

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MISC (178)：

片岡伸介, 佐治木大知, 津村悠介, 前村遼, 今屋雅之, 山森彩子, 若松学, 谷口理恵子, 濱田太立, 西川英里, et al. 脊髄圧迫によるoncologic emergencyを呈した大腰筋内の後腹膜腫瘍. 日本小児血液・がん学会雑誌. 2022. 59. 1. 72-72
山下大紀, 村松秀城, 今屋雅之, 山森彩子, 若松学, 片岡伸介, 濱田太立, 谷口理恵子, 川島希, 西川英里, et al. TREC測定による新生児マススクリーニングにより診断され同種臍帯血移植を行ったX連鎖重症複合免疫不全症. 日本小児科学会雑誌. 2022. 126. 2. 281-281
Nozomu Kawashima, Shinsuke Kataoka, Motoharu Hamada, Eri Nishikawa, Rieko Taniguchi, Atsushi Narita, Hideki Muramatsu, Nobuhiro Nishio, Yoshiyuki Takahashi. Prolonged Hospitalization and Late Gastroenterological Complications in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. PEDIATRIC BLOOD & CANCER. 2021. 68
Motoharu Hamada, Masayuki Imaya, Yusuke Okuno, Nozomu Kawashima, Rieko Taniguchi, Atsushi Narita, Hideki Muramatsu, Nobuhiro Nishio, Shinji Hasegawa, Yoshiyuki Takahashi. Strategy of Intensified Therapy for High Risk Pediatric Acute Lymphoblastic Leukemia Based on NGS-MRD-Based Risk Stratification. PEDIATRIC BLOOD & CANCER. 2021. 68
Masayuki Imaya, Nobuhiro Nishio, Rieko Taniguchi, Shinsuke Kataoka, Motoharu Hamada, Eri Nishikawa, Nozomu Kawashima, Atsushi Narita, Hideki Muramatsu, Yoshiyuki Takahashi. Using Chemotherapy to Treat Neuroblastoma Stage 4S with Hepatomegaly in a Patient Younger than 2 Months Old. PEDIATRIC BLOOD & CANCER. 2021. 68

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Lectures and oral presentations (17)：

Strategy of intensified therapy for high risk pediatric acute lymphoblastic leukemia based on NGS-MRD-based risk stratification
(2021)
HLA one-allele mismatched unrelated BMT using antithymocyte globulin in Japanese pediatric patients.
(2021)
小児再発・難治神経芽腫の自家末梢血幹細胞採取におけるプレリキサホル有効性に関する検討
(第43回日本造血細胞移植学会総会. 2021)
Diagnostic whole exome sequencing for 166 patients with inherited bone marrow failure syndrome.
(The 62nd ASH Annual Meeting and Exposition. 2020)
Strategy of stem cell transplantation at 1st molecular CR for pediatric acute lymphoblastic leukemia with MEF2D-BCL9 fusion
(2020)

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Education (2)：

2015 - 2019 Nagoya University Graduate School of Medicine
2004 - 2009 Nagoya University School of Medicine

Professional career (1)：

Ph.D (Graduate School of Medicine, Nagoya University)

Work history (7)：

2022/04 - 現在 Nagoya City University Graduate School of Medical Sciences Department of Virology
2019/04 - 2022/03 Nagoya university hospital
2015/10 - 2019/03 名古屋大学医学部附属病院小児科医員
2014/10 - 2015/09 名古屋第一赤十字病院小児医療センター医師
2014/04 - 2014/09 名古屋大学医学部附属病院小児科医員

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Committee career (1)：

2021/04 - 現在 Japan Children's Cancer Group Acute lymphoblastic leukemia committee

Awards (4)：

2022/10 - 公益信託日本白血病研究基金令和4年度公益信託日本白血病研究基金一般研究賞キメラ抗原受容体T(CAR-T)細胞製剤の改善に向けた抗腫瘍効果の高いT細胞集団の同定とその特徴の解明
2022/09 - 公益財団法人持田記念医学薬学振興財団 2022年度公益財団法人持田記念医学薬学振興財団研究助成ナンセンス変異依存 mRNA 分解機構の異常により遺伝性骨髄不全症候群を発症する新たな疾患概念の確立
2021/10 - 日本血液学会第82回日本血液学会学術集会奨励賞 Diagnostic whole exome sequencing for 166 patients with inherited bone marrow failure syndrome
2019/10 - 順清会(名古屋大学小児科) 第44回順清会研究奨励賞新規tagmentation-assisted PCR法を用いたCD19キメラ抗原受容体遺伝子導入T細胞(CAR-T細胞)の遺伝子挿入部位解析

Association Membership(s) (4)：

日本造血・免疫細胞療法学会 , 日本血液学会 , 日本小児血液・がん学会 , 日本小児科学会

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