KUSHIKATA Tetsuya

クシカタテツヤ | KUSHIKATA Tetsuya

Affiliation and department：
Job title： Associate Professor

Research field (2)： Anesthesiology , Clinical pharmacy

Research keywords (5)： mechanism of general anesthesia , sleep , orexin , noradrenaline , neuropeputaide S

Research theme for competitive and other funds (26)：

2021 - 2026 Regulation of anesthetic efficacy through GABA-A R phosphorilation
2021 - 2025 Clinical study for preoperative prediction of depression in older adult patients by deep learning and basic study for clarifying mechanism of depression and developing its prophylaxis.
2020 - 2023 自律神経機能調節に注目した新しい集中治療時の鎮静法の探求
2019 - 2023 うつ病病態発現神経回路の解明とケタミン抗うつ作用機序の検討
2020 - 2023 バーチャルリアリティを用いたプレハビリテーションプログラムによる術後譫妄予防

2018 - 2022 術後アウトカム指向麻酔法の探求:内因性睡眠物質を応用した円滑な周術期管理への道標

2018 - 2021 Study of regulatory system for anesthetic efficacy using GABA-A receptor plasticity

2017 - 2021 Investigation of mechanism of pathogenesis of postoperative and sepsis-associated delirium and cognitive dysfunction and development of the prophylaxis.

2015 - 2018 Role of orexinergic neurons in sepsis

2014 - 2018 Searching way of more gentle emergence from general anesthesia-An approach from anesthesiology and sleep to ERAS-

2012 - 2015 Study on analgesic effects of neuropeptide S

2011 - 2013 A study on the treatment of post anesthesia and surgical sleep disturbance

2010 - 2012 Sleep and general anesthesia : maintaining patient safety and improving the QOL during perioperative period

2009 - 2012 Stud for the mechanism of aging and anesthesia-related sleep disorder and its treatment.

2008 - 2010 Study on a mechanism of emergence from general anesthesia-apply of the ascending arousal system for smooth recovery from general anesthesia

2007 - 2009 生理活性物質ウロテンシンIIの全身麻酔および睡眠への関与

2006 - 2008 The relationship between sleep and anesthesia as a clueto elucidate the mechanism of general anesthesia

2005 - 2007 Brain orexinergic-noradrenergic neurons and mechanism of general anesthesia

2005 - 2007 A study of post anesthetic and operative sleep disturbance. An approach to the mechanism and treatment on the disturbance.

2002 - 2004 Unitary mechanism of general anesthesia using brain noradrenergic neuronal network.

2003 - 2003 全身麻酔中の低体温予防の研究-中枢性ノルエピネフリン作動性神経活性は関与するか

2001 - 2002 A study on the mechanism of General Anesthesia-inuduced sleep-relation to endogenous sleep related substances

2000 - 2002 Relationship between sleep and anesthesia

1997 - 2000 Contribution of L-type Voltage Sensitive Ca^<2+> Channels to Mechanism of General Anesthesia

1993 - 1994 Pharmacokinetic study for target controlled infusion of ketamine and fentanyl

1993 - 1993 マイクロダイアリシス法を用いた麻酔下における神経伝達物質の動向に関する研究

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Papers (151)：

Naoki Hirai, Hirotaka Kinoshita, Masato Kitayama, Tetsuya Kushikata, Kazuyoshi Hirota. Anesthetic management of external iliac artery transection in a morbidly obese patient with Klippel-Trenaunay-Weber syndrome: a case report. JA Clinical Reports. 2023. 9. 1
Hirotaka Kinoshita, Junichi Saito, Tetsuya Kushikata, Tasuku Oyama, Daiki Takekawa, Eiji Hashiba, Teiji Sawa, Kazuyoshi Hirota. The Perioperative Frontal Relative Ratio of the Alpha Power of Electroencephalography for Predicting Postoperative Delirium After Highly Invasive Surgery: A Prospective Observational Study. Anesthesia and analgesia. 2023
Gentaro Kumagai, Kanichiro Wada, Toru Asari, Yohshiro Nitobe, Hirotaka Kinoshita, Tetsuya Kushikata, Kazuyoshi Hirota, Yasuyuki Ishibashi. Association of cervical atherosclerosis on Doppler ultrasonography and postoperative delirium in patients undergoing spinal surgery: a single-center, retrospective, observational study. European Spine Journal. 2023
Tasuku Oyama, Hirotaka Kinoshita, Daiki Takekawa, Junichi Saito, Tetsuya Kushikata, Kazuyoshi Hirota. Higher neutrophil-to-lymphocyte ratio, mean platelet volume, and platelet distribution width are associated with postoperative delirium in patients undergoing esophagectomy: a retrospective observational study. Journal of anesthesia. 2022. 36. 1. 58-67
Masahiro Akaishi, Eiji Hashiba, Daiki Takekawa, Tetsuya Kushikata, Kazuyoshi Hirota. Plasma orexin A does not reflect severity of illness in the intensive care units patients with systemic inflammation. JA clinical reports. 2022. 8. 1. 7-7

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MISC (193)：

櫛方哲也. 【最新主要文献とガイドラインでみる麻酔科学レビュー 2023】静脈麻酔薬(麻薬を除く). 麻酔科学レビュー. 2023. 2023. 35-41
木下裕貴, 櫛方哲也, 廣田和美. 全身麻酔中の脳波研究最前線高侵襲手術における全身麻酔中の脳波変化と術後せん妄の関連. 日本臨床麻酔学会誌. 2022. 42. 6. S115-S115
濱欠美優, 三浦菜々, 工藤怜子, 櫛方哲也, 廣田和美. 麻酔科術前診察で重症大動脈弁閉鎖不全症が判明しリスクを回避した一例. 日本臨床麻酔学会誌. 2022. 42. 6. S205-S205
内田達士, 木下裕貴, 竹川大貴, 大山翼, 櫛方哲也, 廣田和美. The effects of acute normovolemic hemodilution to the postoperative delirium in patients undergoing free-flap reconstruction of the head and neck: A retrospective observational study. 日本麻酔科学会学術集会(Web). 2022. 69th
竹川大貴, 櫛方哲也, 木下裕貴, 廣田和美. Effects of the orexigenic neurons on sleep disorders due to low-grade inflammation. 日本麻酔科学会学術集会(Web). 2022. 69th

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