Rchr
J-GLOBAL ID：202201007490295572
Update date: Sep. 08, 2024
Tsutsumi Hayama
ツツミ ハヤマ | Tsutsumi Hayama
Affiliation and department：
Job title：
Project Assistant Professor
Research field (2)：
Bioorganic chemistry
, Applied microbiology
Research keywords (3)：
Microbiology
, Enzyme
, Biosynthesis
Research theme for competitive and other funds (3)：
- 2023 - 2025 Prediction and analysis of natural product biosynthetic clusters which cannot be predicted by conventional methods
- 2022 - 2025 耐性遺伝子を指標とした微生物資源からの新規薬剤シーズの探索
- 2018 - 2020 放線菌の生産する窒素を含む多環性化合物群の生合成研究
Papers (15)：
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Aoi Kimishima, Atsuka Nishitomi, Iori Tsuruoka, Katsuyuki Sakai, Rei Hokari, Masako Honsho, Sota Honma, Yuki Ono, Naozumi Kondo, Hayama Tsutsumi, et al. Discovery of an anti-malarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity. Bioscience, Biotechnology, and Biochemistry. 2024
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Yuta Awano, Ryoya Ishii, Yume Takahashi, Hayama Tsutsumi, Yoshihiro Watanabe, Masaaki Sonoda, Rei Hokari, Masato Iwatsuki, Yuki Inahashi. A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017. The Journal of Antibiotics. 2024
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Aoi Kimishima, Yuki Suzuki, Shohei Kosaka, Masako Honsho, Sota Honma, Hayama Tsutsumi, Yuki Inahashi, Yoshihiro Watanabe, Takuji Nakashima, Yukihiro Asami, et al. Binding Mode-Based Physicochemical Screening Method Using d-Ala-d-Ala Silica Gel and Chemical Modification Approach to Facilitate Discovery of New Macrolactams, Banglactams A and B, from Nonomuraea bangladeshensis K18-0086. ACS Omega. 2024
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So-Ichiro Kimura, Yoshihiro Watanabe, Yuta Kikuchi, Shiori Shibasaki, Hayama Tsutsumi, Yuki Inahashi, Rei Hokari, Aki Ishiyama, Masato Iwatsuki. Akedanones A-C, In Vitro and In Vivo Antiplasmodial 2,3-Dihydronaphthoquinones Produced by Streptomyces sp. K20-0187. Journal of natural products. 2024
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Aoi Kimishima, Iori Tsuruoka, Hayama Tsutsumi, Masako Honsho, Sota Honma, Hidehito Matsui, Miho Sugamata, Paul Wasuwanich, Yuki Inahashi, Hideaki Hanaki, et al. A new tetronomycin analog, broad-spectrum and potent antibiotic against drug-resistant Gram-positive bacteria. Chemistry & biodiversity. 2024. e202301834
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MISC (21)：
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堤隼馬, 堤隼馬, 大西康夫, 大西康夫, 勝山陽平, 勝山陽平. 実験と計算化学を組み合わせたゲラニル二リン酸C6位メチル基転移酵素の機能解析と合理的改変による基質特異性の改変. 酵素工学ニュ-ス. 2023. 90
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菊池雄太, 渡邊善洋, 川口彩乃, 堤隼馬, 伊藤翔, 岩月正人, 稲橋佑起. Analysis of secondary metabolite biosynthetic potential in rare actinomycetes and searching for novel natural products from their metabolites. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
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鶴岡伊織, 君嶋葵, 菅藤裕貴, 堤隼馬, 有馬直明, 酒井一成, 菅又美穂, 松井秀仁, 渡邊善洋, 岩月正人, et al. Rediscovery of tetronomycin as a broad-spectrum and potent antibiotic against drug-resistant gram-positive bacteria. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
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金井田將裕, 野口吉彦, 堤隼馬, 稲橋佑起, 廣瀬友靖, 砂塚敏明. Synthetic study of middle-sized natural product Dityromycin toward the creation of novel PPI inhibitor. 日本薬学会年会要旨集(Web). 2022. 142nd
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菊池雄太, 堤隼馬, 堤隼馬, 稲橋佑起, 稲橋佑起. Analyzing the ability to produce secondary metabolites of actinomycetes using genome information. 日本放線菌学会大会講演要旨集. 2022. 36th
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Education (3)：
- 2015 - 2020 The University of Tokyo Graduate School of Agricultural and Life Sciences
- 2012 - 2015 The University of Tokyo
- 2010 - 2012 The University of Tokyo College of Arts and Sciences
Professional career (1)：
- Ph. D. (Agriculture) (The University of Tokyo)
Work history (3)：
- 2021/04 - 現在 北里大学大学院感染制御科学府 特任助教
- 2020/04 - 2021/03 Graduate School of Agricultural and Life Sciences, The University of Tokyo
- 2018/04 - 2020/03 日本学術振興会 特別研究員DC2
Association Membership(s) (2)：
The Society for Actinomycetes Japan
, Japan Society for Bioscience, Biotechnology, and Agrochemistry
