Rchr
J-GLOBAL ID：202201008976786388
Update date: Oct. 24, 2024
Tsutsumi Naotaka
ツツミ ナオタカ | Tsutsumi Naotaka
Affiliation and department：
Job title：
Specially Appointed Associate Professor
Homepage URL (1)：
https://www.linkedin.com/in/naotaka-tsutsumi-8b4571129/
Research theme for competitive and other funds (5)：
- 2024 - 2028 味覚受容体T1rのハロゲンイオン感知能を基盤とする分子機能と生理学的役割の開拓
- 2024 - 2028 Structural study of the initial transducer engagement by GPCR
- 2024 - 2027 タンパク質工学による難生産性タンパク質生産法の確立
- 2022 - 2026 Structural Basis of the Signaling Selection Mechanism of Ghrelin Receptor
- 2022 - 2024 Structure-function analysis of human bitter taste receptors
Papers (23)：
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Naotaka Tsutsumi, Zahra Masoumi, Sophie C. James, Julie A. Tucker, Hauke Winkelmann, William Grey, Lora K. Picton, Lucie Moss, Steven C. Wilson, Nathanael A. Caveney, et al. Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis. Cell. 2023. 186. 19. 4189-4203.e22
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Nathanael A Caveney, Naotaka Tsutsumi, K Christopher Garcia. Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism. eLife. 2023. 12. RP86784
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Titouan Jaunet-Lahary, Tatsuro Shimamura, Masahiro Hayashi, Norimichi Nomura, Kouta Hirasawa, Tetsuya Shimizu, Masao Yamashita, Naotaka Tsutsumi, Yuta Suehiro, Keiichi Kojima, et al. Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota. Nature Communications. 2023. 14. 1730
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Nathanael A. Caveney, Robert A. Saxton, Deepa Waghray, Caleb R. Glassman, Naotaka Tsutsumi, Stevan R. Hubbard, K. Christopher Garcia. Structural basis of Janus kinase trans-activation. Cell Reports. 2023. 42. 112201
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Naotaka Tsutsumi, Sunhee Hwang, Deepa Waghray, Simon Hansen, Kevin M. Jude, Nan Wang, Yi Miao, Caleb R. Glassman, Nathanael A. Caveney, Claudia Y. Janda, et al. Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 11. e2218238120
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MISC (7)：
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Naotaka Tsutsumi, Dagmar F. Kildedal, Olivia K. Hansen, Qianqian Kong, Dominique Schols, Tom Van Loy, Mette M. Rosenkilde. Insight into structural properties of viral G protein-coupled receptors and their role in the viral infection: IUPHAR Review 41. British Journal of Pharmacology. 2024. 1-26
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Naotaka Tsutsumi. Visualization of G protein activation by a GPCR (Japanese commentary). Gendai Kagaku (Current Chemistry). 2024. 6. 639. 9-10
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Naotaka Tsutsumi. Structure of the thrombopoietin-MPL receptor complex guides design of the cytokine variants that bias hematopoiesis (Japanese). Experimental Medicine. 2024. 42. 4. 579-582
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Naotaka Tsutsumi. Illuminating Initiation of Canonical Wnt/β-catenin Signaling by Directed Evolution and Structural Biology (Japanese). Seibutsu Butsuri (Biophysics). 2023. 63. 6. 313-315
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Mette M. Rosenkilde, Naotaka Tsutsumi, Julius M. Knerr, Dagmar F. Kildedal, K. Christopher Garcia. Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses. Annual Review of Virology. 2022. 9. 1. 329-351
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Lectures and oral presentations (4)：
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Structural evolution of human cytomegalovirus GPCRs US27 and US28
(The 4th European Chemokine and Cell Migration Conference (ECMC2023) 2023)
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New Stage of Development in Structural Biology of Membrane Protein Complexes to Accelerate Life Science Research
(The 23rd Annual Meeting of the Protein Science Society of Japan 2023)
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Frontiers in structural biology toward drug discovery
(The 143rd Annual Meeting of the Pharmaceutical Society of Japan 2023)
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Structural mechanism of Janus kinase activation
(20th IPR Retreat 2022)
Professional career (1)：
Awards (6)：
Association Membership(s) (2)：
The Pharmaceutical Society of Japan
, The Molecular Biology Society of Japan
