KOYANAGI Satoru

コヤナギサトル | KOYANAGI Satoru

Affiliation and department：
Job title： Professor

Research keywords (3)： Clock gene , Circadian Clock , Chronopharmacotherapy

Research theme for competitive and other funds (18)：

2022 - 2025 がん突発痛の概日性発症メカニズムを基盤にした鎮痛標的分子の探索
2022 - 2025 細胞伝達時計の機能解析と創薬育薬を指向した基礎的研究
2020 - 2022 Elucidation of the generation mechanism of cancer stem cells from circadian clock defective cells and development of strategy for overcoming of chemoresistance
2018 - 2022 Integration analysis between RNA editing and circadian clock system for elucidation of interindividual variation of drug pharmacokinetics
2017 - 2019 Study on molecular mechanism for scaffold protein-regulated circadian localization of transporters on plasma membrane by

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Papers (135)：

Yuya Yoshida, Taiki Fukuda, Tomohito Tanihara, Naoki Nishikawa, Serina Iwasa, Satoka Adachi, Orion Zaitsu, Yuma Terada, Ryotaro Tsukamoto, Hideki Shimoshikiryo, et al. Circadian rhythms in CYP2A5 expression underlie the time-dependent effect of tegafur on breast cancer. Biochemical and Biophysical Research Communications. 2024. 708. 149813-149813
Ai Sato, Sai Yasukochi, Naho Iwanaka, Tomoaki Yamauchi, Akito Tsuruta, Satoru Koyanagi, Shigehiro Ohdo. Dosing time-dependent difference in the suppressive effect of empagliflozin on the development of mechanical pain hypersensitivity in diabetic mice. Journal of Pharmacology and Experimental Therapeutics. 2024
Yuya Yoshida, Kohei Fukuoka, Miyu Sakugawa, Masayuki Kurogi, Kengo Hamamura, Keika Hamasaki, Fumiaki Tsurusaki, Kurumi Sotono, Takumi Nishi, Taiki Fukuda, et al. Inhibition of G protein-coupled receptor 68 using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment. Translational research : the journal of laboratory and clinical medicine. 2024
Yuya Tsurudome, Yuya Yoshida, Kengo Hamamura, Takashi Ogino, Sai Yasukochi, Shinobu Yasuo, Ayaka Iwamoto, Tatsuya Yoshihara, Tomoaki Inazumi, Soken Tsuchiya, et al. Prostaglandin F2α Affects the Cycle of Clock Gene Expression and Mouse Behavior. International journal of molecular sciences. 2024. 25. 3
Wakaba Yamakawa, Sai Yasukochi, Yuya Tsurudome, Naoki Kusunose, Yuta Yamaguchi, Akito Tsuruta, Naoya Matsunaga, Kentaro Ushijima, Satoru Koyanagi, Shigehiro Ohdo. Suppression of neuropathic pain in the circadian clock-deficient Per2m/m mice involves up-regulation of endocannabinoid system. PNAS Nexus. 2023. 3. 1

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MISC (18)：

山川稚葉, 安河内冴, 鶴留優也, 牛島健太郎, 鶴田朗人, 松永直哉, 小柳悟, 大戸茂弘. Mechanistic analysis for prevention of neuropathic pain development during the disturbance of circadian rhythm. 日本薬学会年会要旨集(Web). 2022. 142nd
山川稚葉, 安河内冴, 鶴留優也, 牛島健太郎, 鶴田朗人, 松永直哉, 小柳悟, 大戸茂弘. 時計遺伝子の機能不全マウスにおける神経障害性疼痛の発症抑制メカニズムの解析. 次世代を担う若手のための創薬・医療薬理シンポジウムプログラム・要旨集. 2022. 2022
小柳悟, 加藤泉希, 鶴留優也, 安河内冴, 松永直哉, 大戸茂弘. 白金製剤オキサリプラチン誘発の骨髄抑制に及ぼす薬物排泄トランスポーターMRP4の概日リズムの影響. Fundamental Toxicological Sciences (Web). 2021. 8. Supplement
山川稚葉, 安河内冴, 鶴留優也, 牛島健太郎, 鶴田朗人, 松永直哉, 小柳悟, 大戸茂弘. 神経障害性疼痛の発症における時計遺伝子Period2の機能解析. 日本薬学会九州支部大会講演要旨集. 2021. 38th
木藤弘子, 石田保美, 赤嶺孝祐, 橋本華, 國見美紀, 諸岡由美子, 廣渡隆, 小柳悟, 大戸茂弘, 神村英利. パリペリドン錠一包化後の放出特性と患者の評価. 薬理と治療. 2016. 44. 1. 65-69

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Awards (3)：

2021/03 - 日本薬学会学術振興賞「病態・薬効の概日変動メカニズムを基盤にした時間薬剤学研究」
2013/10 - 日本薬物動態学会学術奨励賞「時計遺伝子を基盤にした薬物動態制御因子の概日変動メカニズムに関する研究」
2008/11 - 日本時間生物学会学術振興賞「体内時計の分子機構を基盤にした抗癌剤の創薬・育薬研究」

Association Membership(s) (7)：

日本薬学会 , 日本薬物動態学会 , 日本薬剤学会 , 日本時間生物学会 , 日本薬理学会 , 日本臨床薬理学会 , 日本毒性学会

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