2017 - 2021 Comprehensive understanding of the phospholipid flip mechanism in the endoplasmic reticulum and establishment of the control technology of biomembrane dynamics
2016 - 2018 Aggregation of amyloid-beta protein on size-controlled lipid nanoparticles
2014 - 2017 Elucidation of dynamic control of biomembrane functions by phospholipid transfer proteins
2014 - 2016 Structure and molecular interactions in aggregation of amyloid beta protein
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Papers (47):
Keisuke Ikeda, Yuuki Sugiura, Hiroyuki Nakao, Minoru Nakano. Thermodynamics of oligomerization and Helix-to-sheet structural transition of amyloid β-protein on anionic phospholipid vesicles. Biophysical chemistry. 2024. 310. 107248-107248
Hiroyuki Nakao, Michihiro Nagao, Takeshi Yamada, Koki Imamura, Koichi Nozaki, Keisuke Ikeda, Minoru Nakano. Impact of transmembrane peptides on individual lipid motions and collective dynamics of lipid bilayers. Colloids and Surfaces B: Biointerfaces. 2023. 228. 113396-113396
Motomi Matsuda, Keisuke Ikeda, Tomoshi Kameda, Hiroyuki Nakao, Minoru Nakano. Fine-Tuning and Enhancement of pH-Dependent Membrane Permeation of Cyclic Peptides by Utilizing Noncanonical Amino Acids with Extended Side Chains. Journal of medicinal chemistry. 2023
Ayari Miyajima, Hiroyuki Nakao, Keisuke Ikeda, Minoru Nakano. The Nanometer-Scale Proximity of Bilayers Facilitates Intermembrane Lipid Transfer. The journal of physical chemistry letters. 2023. 4172-4178
Kiyoto Kamagata, Atsumi Hando, Maulana Ariefai, Nanako Iwaki, Saori Kanbayashi, Ryotaro Koike, Keisuke Ikeda. Rational design of phase separating peptides based on phase separating protein sequence of p53. Scientific reports. 2023. 13. 1. 5648-5648
清水裕道, 中尾裕之, 池田恵介, 中野実. Phosphatidylserine externalization in the plasma membrane by transmembrane peptides. 日本薬学会年会要旨集(Web). 2022. 142nd
池田恵介. Interactions between Intra- and Extracellular Vesicles and Amyloid- β Protein : Promotion of Fibril Formation by Highly Curved Lipid Membranes. 膜. 2021. 46. 1
松田幹望, 池田恵介, 中尾裕之, 中野実. Effect of side chain length of acidic amino acids on pH-dependent binding, insertion, and permeation of cyclic peptides into lipid membranes. 日本膜学会年会講演要旨集(CD-ROM). 2021. 43rd
中尾裕之, 木村優介, 池田恵介, 中野実. Induction of phagocytosis by lipid flip-flop promoting peptides. 日本膜学会年会講演要旨集(CD-ROM). 2021. 43rd