Shirai Yoshihiro

シライヨシヒロ | Shirai Yoshihiro

Affiliation and department：
Job title： Clinical Associate

Research field (1)： Digestive surgery

Research keywords (4)： pancreatic cancer , Lysosome , Cancer immunology , Cancer microenvironment

Research theme for competitive and other funds (14)：

2024 - 2027 癌微小環境に着目した肝細胞癌の分子標的薬耐性メカニズム解明と革新的治療法の開発
2024 - 2027 肝細胞癌の宿主免疫回避機構の解明に基づく新たな治療戦略の開発
2024 - 2027 肝癌微小環境における癌関連血管内皮細胞の分子生物学的機能解明と革新的治療法開発
2023 - 2026 Analysis of lysosome enzymes in pancreatic cancer specific immune evasion system
2021 - 2024 The molecular mechanism of hepatocellular carcinoma associated fibroblast oriented exosome miRNA

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Papers (187)：

Munetoshi Akaoka, Koichiro Haruki, Yuto Yamahata, Kohei Okazaki, Kenei Furukawa, Masashi Tsunematsu, Yoshihiro Shirai, Shinji Onda, Michinori Matsumoto, Toru Ikegami. The prognostic impact of perioperative dynamic changes in cachexia index in patients with hepatocellular carcinoma. Annals of gastroenterological surgery. 2024. 8. 5. 917-926
Yuta Yamada, Kenei Furukawa, Koichiro Haruki, Norimitsu Okui, Yoshihiro Shirai, Masashi Tsunematsu, Mitsuru Yanagaki, Jungo Yasuda, Shinji Onda, Toru Ikegami. Abdominal aortic calcification volume as a preoperative prognostic predictor for pancreatic cancer. Surgery today. 2024
Yosuke Igarashi, Koichiro Haruki, Kenei Furukawa, Tomohiko Taniai, Mitsuru Yanagaki, Norimitsu Okui, Yoshihiro Shirai, Masashi Tsunematsu, Taro Sakamoto, Toru Ikegami. Short-term Outcomes of Laparoscopic Versus Open Liver Resection in the Elderly: A Propensity Score-matched Analysis. Anticancer research. 2024. 44. 6. 2731-2736
Koichiro Haruki, Masashi Tsunematsu, Kazutaka Gomisawa, Hirokazu Ashida, Kenei Furukawa, Yoshihiro Shirai, Yuta Yamada, Shun Sato, Shinji Onda, Toru Ikegami. Histological and radiological analysis of simultaneous dual hepatic vein embolization for right-sided major hepatectomy. Surgery today. 2024
Mitsuru Yanagaki, Shinji Onda, Takeshi Gocho, Yosuke Igarashi, Yoshihiro Shirai, Norimitsu Okui, Michinori Matsumoto, Taro Sakamoto, Koichiro Haruki, Toru Ikegami. Prognostic impact of osteosarcopenia in patients undergoing pancreatic resection for pancreatic ductal adenocarcinoma. Langenbeck's archives of surgery. 2024. 409. 1. 130-130

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MISC (260)：

春木孝一郎, 古川賢英, 赤岡宗紀, 柳垣充, 谷合智彦, 恩田真二, 奥井紀光, 松本倫典, 白井祥睦, 池上徹. 肝細胞癌切除例におけるオステオペニア合併椎体骨折の臨床的意義. 日本外科学会定期学術集会(Web). 2024. 124th
谷合智彦, 春木孝一郎, 古川賢英, 柳垣充, 赤岡宗紀, 恩田真二, 白井祥睦, 丹治芳明, 五十嵐陽介, 羽村凌雅, et al. Vessels encapsulating tumor clusters陽性肝細胞癌の免疫細胞プロファイリング. 日本外科学会定期学術集会(Web). 2024. 124th
後町武志, 坂本太郎, 石崎俊太, 柳垣充, 白井祥睦, 春木孝一郎, 奥井紀光, 古川賢英, 松本倫典, 宇和川匡, et al. 正常膵に対する膵頭十二指腸切除術における膵胃吻合の意義. 日本外科系連合学会誌. 2024. 49. 3
柳垣充, 春木孝一郎, 古川賢英, 恩田真二, 石崎俊太, 白井祥睦, 奥井紀光, 松本倫典, 坂本太郎, 後町武志, et al. 肝細胞癌におけるARID4B発現の分子生物学的意義と予後因子としての有用性. 日本外科学会定期学術集会(Web). 2024. 124th
坂本太郎, 後町武志, 柳垣充, 恒松雅, 奥井紀光, 松本倫典, 宇和川匡, 白井祥睦, 羽村凌雅, 池上徹. CY陽性膵癌のconversion手術へ向けた諸問題. 膵臓(Web). 2023. 38. 3

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Education (2)：

2013 - 2016 The Jikei University School of Medicine Graduate School
2004 - 2010 Jikei University Faculty of Medicine

Work history (4)：

2018/04 - 現在 Jikei University
2016/04 - 2018/03 Jikei University
2012/04 - 2013/03 Jikei University
2010/04 - 2012/03 東京慈恵会医科大学付属病院初期臨床研修医

Awards (3)：

2021/04 - The 121st Annual Congress of Japan Surgical Society Young Investigator's Award
2016/06 - Joint Meeting of the Royal College of Surgeons and The Japan Surgical Society Best Paper Award Recombinant thrombomodulin suppresses tumor growth of pancreatic cancer by blocking thrombin-induced PAR1 and NF-κB activation
2016/02 - 11th Annual academic surgical congress JSS top abstract ecombinant thrombomodulin suppresses tumor growth of pancreatic cancer in mice by inhibition of NF-κB activation

Association Membership(s) (12)：

日本癌学会 , 日本消化器癌発生学会 , 日本癌治療学会 , 日本膵臓学会 , 日本臨床腫瘍学会 , 日本内視鏡外科学会 , 日本肝臓学会 , 日本外科学会 , 日本消化器内視鏡学会 , 日本消化器病学会 , 日本肝胆膵外科学会 , 日本消化器外科学会

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