Notomi Takuya

Research theme for competitive and other funds (11)：

2021 - 2024 Identification of mechano-memory for regulating promotion/suppression of osteoclast differentiation
2020 - 2022 Control of the fusion and membrane dynamics for lysosome-cell membrane based on organelle membrane potential.
2018 - 2022 Bone remodeling via RANL/OPG intracellular transportation
2015 - 2018 Proton leak mechanisms in acidic environments
2015 - 2017 The regulation of osteocyte function and mechanosignaling via light stimulus

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Papers (39)：

Takuya Notomi, Miyuki Kuno, Akiko Hiyama, Tadashige Nozaki, Kiyoshi Ohura, Yoichi Ezura, Masaki Noda. Role of lysosomal channel protein TPC2 in osteoclast differentiation and bone remodeling under normal and low-magnesium conditions. The Journal of biological chemistry. 2017. 292. 51. 20998-21010
Tetsuya Nakamoto, Yayoi Izu, Makiri Kawasaki, Takuya Notomi, Tadayoshi Hayata, Masaki Noda, Yoichi Ezura. Mice Deficient in CIZ/NMP4 Develop an Attenuated Form of K/BxN-Serum Induced Arthritis. Journal of cellular biochemistry. 2016. 117. 4. 970-7
Smriti Aryal A C, Kentaro Miyai, Yayoi Izu, Tadayoshi Hayata, Takuya Notomi, Masaki Noda, Yoichi Ezura. Nck influences preosteoblastic/osteoblastic migration and bone mass. Proceedings of the National Academy of Sciences of the United States of America. 2015. 112. 50. 15432-7
Takuya Notomi, Miyuki Kuno, Akiko Hiyama, Yoichi Ezura, Masashi Honma, Toru Ishizuka, Kiyoshi Ohura, Hiromu Yawo, Masaki Noda. Membrane depolarization regulates intracellular RANKL transport in non-excitable osteoblasts. Bone. 2015. 81. 306-314
Makiri Kawasaki, Yoichi Ezura, Tadayoshi Hayata, Takuya Notomi, Yayoi Izu, Masaki Noda. TGF-β Suppresses Ift88 Expression in Chondrocytic ATDC5 Cells. Journal of cellular physiology. 2015. 230. 11. 2788-95

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MISC (10)：

Takuya Notomi, Miyuki Kuno, Akiko Hiyama, Yoichi Ezura, Kiyoshi Ohura, Masaki Noda. Role of the lysosomal channel, Two Pore Channel 2, in osteoclast differentiation and bone remodeling under normal and low-magnesium conditions. JOURNAL OF BONE AND MINERAL RESEARCH. 2017. 32. S235-S235
Yoichi Ezura, Tadayoshi Hayata, Takuya Notomi, Ichiro Sekiya, Masaki Noda. Preferentially expressed genes in synovium derived stromal cells include atypical genes not expressed highly in mouse synovium but in embryonic cartilages. JOURNAL OF BONE AND MINERAL RESEARCH. 2014. 29. S236-S236
Takuya Notomi, Ikuaki Karasaki, Yuichi Okazaki, Nobukazu Okimoto, Yushi Kato, Kiyoshi Ohura, Masaki Noda, Toshitaka Nakamura, Masashige Suzuki. Insulinogenic sucrose plus amino acids mixture ingestion immediately after resistance exercise has an anabolic effect on bone compared with non-insulinogenic fructose plus amino acids mixture in growing rats. JOURNAL OF BONE AND MINERAL RESEARCH. 2014. 29. S138-S138
Takuya Notomi, Yoichi Ezura, Masaki Noda. The role of ion channel and regulation of intracellular Ca2+ during osteoclast differentiation. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 67P-67P
Takuya Notomi, Miyuki Kuno, Yoichi Ezura, Masaki Noda. Depolarizing Membrane Potential by PTH and VD3 Regulates RANKL-intracellular Transportation; A Novel Mechanism of PTH- and VD3-induced Osteoclastogenesis. JOURNAL OF BONE AND MINERAL RESEARCH. 2013. 28

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