Nakato Gaku

ナカトウガク | Nakato Gaku

Affiliation and department：
Job title： Vice-Leader

Research field (3)： Immunology , Molecular biology , Gastroenterology

Research keywords (1)： Mucosal Immunology, Gut microbiota, Technology for Controlling the Intestinal Environment

Research theme for competitive and other funds (6)：

2023 - 2026 上皮細胞接着分子EpCAM、TROP2機能解析による粘膜免疫構築メカニズム解明
2022 - 2025 Elucidation of the molecular mechanisms of endurance enhancement by gut microbiota-derived metabolites
2018 - 2021 How EpCAM and TROP2 function in the gastrointestinal tract
2012 - 2015 Comprehensive understanding of a unique intestinal epithelial M cells specialized for luminal particulate antigen uptake
2012 - 2012 腸管上皮細胞の分化及び恒常性維持におけるmiRNAの果たす役割の解明

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Papers (21)：

Maiko Sezaki, Yoshikazu Hayashi, Gaku Nakato, Yuxin Wang, Sayuri Nakata, Subinoy Biswas, Tatsuya Morishima, Md Fakruddin, Jieun Moon, Soyeon Ahn, et al. Hematopoietic stem and progenitor cells integrate microbial signals to promote post-inflammation gut tissue repair. The EMBO journal. 2022. 41. 22. e110712
Akimasa Kure, Tomoya Tsukimi, Chiharu Ishii, Wanping Aw, Nozomu Obana, Gaku Nakato, Akiyoshi Hirayama, Haruna Kawano, Toshiyuki China, Fumitaka Shimizu, et al. Gut environment changes due to androgen deprivation therapy in patients with prostate cancer. Prostate Cancer and Prostatic Diseases. 2022. 26. 2. 323-330
Yuxin Wang, Tatsuya Morishima, Maiko Sezaki, Gaku Nakato, Shinji Fukuda, Yuhua Li, Hitoshi Takizawa. Akkermansia Muciniphila induces chronic extramedullary hematopoiesis through cooperative IL-1R and TLR signals. EMBO reports. 2022
Gaku Nakato, Sohshi Morimura, Michael Lu, Xu Feng, Chuanjin Wu, Mark C. Udey. Amelioration of Congenital Tufting Enteropathy in EpCAM (TROP1)-Deficient Mice via Heterotopic Expression of TROP2 in Intestinal Epithelial Cells. Cells. 2020. 9. 8. 1847-1847
Chuan-Jin Wu, Michael Lu, Xu Feng, Gaku Nakato, Mark C. Udey. Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins. Cells. 2020. 9. 4. 1027-1027

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MISC (1)：

鈴木道雄, 中藤学, 渡会雅久, 木村昌伸, 堀内基弘, 長谷耕二, 飛梅実, 阿戸学, 森川茂, 山田章雄, et al. Brucella abortusは腸管パイエル板からの侵入にM細胞上のプリオン蛋白質(PrPc)を利用する. 日本獣医学会学術集会講演要旨集. 2013. 155回. 223-223

Patents (7)：

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Books (4)：

Lectures and oral presentations (4)：

研究者としての視座を高める海外留学のススメ
(第46回日本比較内分泌学会大会及びシンポジウム(若手企画シンポジウム) 2022)
私たちと腸内細菌:腸内環境を整えて、健康寿命を延ばそう
(健康に働くための腸内細菌セミナー 2019)
腸内環境を整えて生活習慣病を予防し、健康寿命をのばそう
(かながわ発・中高生のためのサイエンスフェア 2018)
Cellular prion protein on Peyer’s patch M cells serve as an invasive receptor for Burucella abortus
(3rd Nagasaki Prion mini-symposium Japan 2012)

Education (3)：

2007 - 2010 Yokohama City University International Graduate School of Arts and Sciences
2005 - 2007 Yokohama City University International Graduate School of Arts and Sciences
2001 - 2005 Toho University Faculty of Science Department of Biomolecular Science

Work history (4)：

2017/06 - 現在 Kanagawa Institute of Industrial Science and Technology Gut environmental design Group Vice leader
2014/04 - 2017/05 National Institutes of Health National Cancer Institute, Dermatology Branch Visiting fellow
2013/04 - 2014/03 Columbia University medical center Department of microbiology and Immunology Reserch fellow
2010/04 - 2013/03 RIKEN RCAI

Awards (2)：

2009/07 - 14th International Congress of Mucosal Immunology Young Investigator Travel Award
2007/07 - 13th International Congress of Mucosal Immunology Young Investigator Travel Award

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