Rchr
J-GLOBAL ID：202201015950307461
Update date: Aug. 01, 2024
Takano Kazunori
タカノ カズノリ | Takano Kazunori
Affiliation and department：
Job title：
Assistant Professor
Research field (2)：
Cell biology
, Functional biochemistry
Research keywords (10)：
Muscle hypertrophy
, N-WASP
, Plasma membrane
, Actin cytoskeleton
, Fluorescent imaging
, Muscle cell fusion
, muscle regeneration
, Intracellular signaling
, Cell migration
, Cytoskeleton
Research theme for competitive and other funds (8)：
- 2021 - 2024 BAR protein and N-WASP-mediated regulation of skeletal muscle fusion by cooperating with cell migration
- 2017 - 2020 Elucidation of mechanism of the nuclear arrangement regulation by N-WASP and membrane deforming protein during skeletal muscle regeneration
- 2015 - 2018 Molecular mechanisms of tissue formation, regeneration, and tumor suppression by the Ras-ERK pathway antagonist DA-Raf
- 2014 - 2017 Elucidation of the mechanism of N-WASP-Nebl complex activation during cardiomyocyte hypertrophy
- 2013 - 2015 Cellular protrusions that transport diverse signaling molecules and the receptors: molecular mechanisms of their formation and their functions in morphogenesis
- 2012 - 2014 Dynamic regulation of actin filament formation in the innervated skeletal muscle
- 2011 - 2014 Signaling and molecular mechanisms of myofibrillogenesis participating in muscle regeneration and muscle and cardiac hypertrophy
- 2010 - 2011 A novel mechanism of act in nucleation by nebulin complex and its physiological role
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Papers (22)：
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Aoi Matsuda, Ryuichi Masuzawa, Kazuya Takahashi, Kazunori Takano, Takeshi Endo. MEK inhibitors and DA-Raf, a dominant-negative antagonist of the Ras-ERK pathway, prevent the migration and invasion of KRAS-mutant cancer cells. Cytoskeleton. 2024. 81. online ahead of print
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Ryuichi Masuzawa, Kazuya Takahashi, Kazunori Takano, Ichizo Nishino, Toshiyuki Sakai, Takeshi Endo. DA-Raf and the MEK inhibitor trametinib reverse skeletal myocyte differentiation inhibition or muscle atrophy caused by myostatin and GDF11 through the non-Smad Ras-ERK pathway. Journal of biochemistry. 2022. 171. 1. 109-122
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Kazuya Takahashi, Eisuke Itakura, Kazunori Takano, Takeshi Endo. DA-Raf, a dominant-negative regulator of the Ras-ERK pathway, is essential for skeletal myocyte differentiation including myoblast fusion and apoptosis. Experimental cell research. 2019. 376. 2. 168-180
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Emiri Kanno, Osamu Kawasaki, Kazuya Takahashi, Kazunori Takano, Takeshi Endo. DA-Raf, a dominant-negative antagonist of the Ras-ERK pathway, is a putative tumor suppressor. Experimental cell research. 2018. 362. 1. 111-120
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Ryo Maeda, Hiroyuki Tamashiro, Kazunori Takano, Hiro Takahashi, Hidefumi Suzuki, Shinta Saito, Waka Kojima, Noritaka Adachi, Kiyoe Ura, Takeshi Endo, et al. TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation. The Journal of biological chemistry. 2017. 292. 8. 3201-3212
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MISC (54)：
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高野和儀, 辻田和也, 伊藤俊樹, 遠藤剛. DA-Rafは細胞膜と活性化Rasに結合することによりRas-ERK経路の全体的抑制因子として機能する. 日本生化学会大会(Web). 2021. 94th. [1T15a-600)]
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増澤龍一, 高橋和也, 高野和儀, 遠藤剛. DA-RafはmyostatinやGDF11による骨格筋細胞分化阻害を解除する. 日本生化学会大会(Web). 2020. 93rd
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松田碧, 増澤龍一, 高野和儀, 遠藤剛. DA-RafはKRAS突然変異がん細胞の遊走と浸潤を抑制する. 日本生化学会大会(Web). 2020. 93rd
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増澤龍一, 永野貴大, 高野和儀, 遠藤剛. Ras-ERK経路に拮抗するDX-Raf蛋白質群の機能の解析. 日本生化学会大会(Web). 2019. 92nd
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高橋和也, 高野和儀, 遠藤剛. Ras-ERK経路拮抗因子DA-Rafは骨格筋細胞分化とアポトーシスに必須である. 日本生化学会大会(Web). 2018. 91st
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Lectures and oral presentations (63)：
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DA-Rafは細胞膜と活性化Rasに結合することによりRas-ERK経路の全体的抑制因子として機能する
(日本生化学会大会(Web) 94th [1T15a-600)] 2021)
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DA-RafはKRAS突然変異がん細胞の遊走と浸潤を抑制する
(日本生化学会大会プログラム・講演要旨集 2020)
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DA-RafはmyostatinやGDF11による骨格筋細胞分化阻害を解除する
(日本生化学会大会プログラム・講演要旨集 2020)
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Ras-ERK経路に拮抗するDX-Raf蛋白質群の機能の解析
(日本生化学会大会プログラム・講演要旨集 2019)
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DA-Rafによるがん化抑制におけるストレスファイバー回復の分子機構
(日本生化学会大会プログラム・講演要旨集 2019)
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Professional career (1)：
- Ph. D. (Chiba University)
Association Membership(s) (3)：
日本筋学会
, 日本生化学会
, 日本細胞生物学会
