Rchr
J-GLOBAL ID：202201015950307461   Update date: Feb. 01, 2024

Takano Kazunori

タカノ カズノリ | Takano Kazunori
Affiliation and department：
Chiba University Department of Biology, Faculty of Science

About Chiba University Department of Biology, Faculty of Science


Job title： Assistant Professor
Research field  (2)： Cell biology ,  Functional biochemistry
Research keywords  (10)： Muscle hypertrophy ,  N-WASP ,  Plasma membrane ,  Actin cytoskeleton ,  Fluorescent imaging ,  Muscle cell fusion ,  muscle regeneration ,  Intracellular signaling ,  Cell migration ,  Cytoskeleton
Research theme for competitive and other funds  (8)：
  • 2021 - 2024 BAR protein and N-WASP-mediated regulation of skeletal muscle fusion by cooperating with cell migration
  • 2017 - 2020 Elucidation of mechanism of the nuclear arrangement regulation by N-WASP and membrane deforming protein during skeletal muscle regeneration
  • 2015 - 2018 Molecular mechanisms of tissue formation, regeneration, and tumor suppression by the Ras-ERK pathway antagonist DA-Raf
  • 2014 - 2017 Elucidation of the mechanism of N-WASP-Nebl complex activation during cardiomyocyte hypertrophy
  • 2013 - 2015 Cellular protrusions that transport diverse signaling molecules and the receptors: molecular mechanisms of their formation and their functions in morphogenesis
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Papers (21)：
  • Ryuichi Masuzawa, Kazuya Takahashi, Kazunori Takano, Ichizo Nishino, Toshiyuki Sakai, Takeshi Endo. DA-Raf and the MEK inhibitor trametinib reverse skeletal myocyte differentiation inhibition or muscle atrophy caused by myostatin and GDF11 through the non-Smad Ras-ERK pathway. Journal of biochemistry. 2022. 171. 1. 109-122
  • Kazuya Takahashi, Eisuke Itakura, Kazunori Takano, Takeshi Endo. DA-Raf, a dominant-negative regulator of the Ras-ERK pathway, is essential for skeletal myocyte differentiation including myoblast fusion and apoptosis. Experimental cell research. 2019. 376. 2. 168-180
  • Emiri Kanno, Osamu Kawasaki, Kazuya Takahashi, Kazunori Takano, Takeshi Endo. DA-Raf, a dominant-negative antagonist of the Ras-ERK pathway, is a putative tumor suppressor. Experimental cell research. 2018. 362. 1. 111-120
  • Ryo Maeda, Hiroyuki Tamashiro, Kazunori Takano, Hiro Takahashi, Hidefumi Suzuki, Shinta Saito, Waka Kojima, Noritaka Adachi, Kiyoe Ura, Takeshi Endo, et al. TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation. The Journal of biological chemistry. 2017. 292. 8. 3201-3212
  • Takeshi Endo, Kazunori Takano. Actin Filament Formation in Myofibrils and Cell Protrusions Regulated by Signal Transduction. Protein Modifications in Pathogenic Dysregulation of Signaling. 2015. 287-307
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MISC (54)：
  • 高野和儀, 辻田和也, 伊藤俊樹, 遠藤剛. DA-Rafは細胞膜と活性化Rasに結合することによりRas-ERK経路の全体的抑制因子として機能する. 日本生化学会大会(Web). 2021. 94th. [1T15a-600)]
  • 増澤龍一, 高橋和也, 高野和儀, 遠藤剛. DA-RafはmyostatinやGDF11による骨格筋細胞分化阻害を解除する. 日本生化学会大会(Web). 2020. 93rd
  • 松田碧, 増澤龍一, 高野和儀, 遠藤剛. DA-RafはKRAS突然変異がん細胞の遊走と浸潤を抑制する. 日本生化学会大会(Web). 2020. 93rd
  • 増澤龍一, 永野貴大, 高野和儀, 遠藤剛. Ras-ERK経路に拮抗するDX-Raf蛋白質群の機能の解析. 日本生化学会大会(Web). 2019. 92nd
  • 高橋和也, 高野和儀, 遠藤剛. Ras-ERK経路拮抗因子DA-Rafは骨格筋細胞分化とアポトーシスに必須である. 日本生化学会大会(Web). 2018. 91st
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Lectures and oral presentations  (63)：
  • DA-Rafは細胞膜と活性化Rasに結合することによりRas-ERK経路の全体的抑制因子として機能する
    (日本生化学会大会(Web) 94th [1T15a-600)] 2021)
  • DA-RafはKRAS突然変異がん細胞の遊走と浸潤を抑制する
    (日本生化学会大会プログラム・講演要旨集 2020)
  • DA-RafはmyostatinやGDF11による骨格筋細胞分化阻害を解除する
    (日本生化学会大会プログラム・講演要旨集 2020)
  • Ras-ERK経路に拮抗するDX-Raf蛋白質群の機能の解析
    (日本生化学会大会プログラム・講演要旨集 2019)
  • DA-Rafによるがん化抑制におけるストレスファイバー回復の分子機構
    (日本生化学会大会プログラム・講演要旨集 2019)
ｍore...
Professional career (1)：
  • Ph. D. (Chiba University)
Association Membership(s) (3)：
日本筋学会 ,  日本生化学会 ,  日本細胞生物学会
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