SUGIYAMA RYOSUKE

スギヤマリョウスケ | SUGIYAMA RYOSUKE

Affiliation and department：
Job title： Assistant Professor
Research theme for competitive and other funds (7)：

2024 - 2027 Natural Products Biology: Physiological significance of plant secondary metabolites
2024 - 2027 配糖体-アグリコン変換反応のダイナミクスから紐解くクマリン類の活性調節機構
2023 - 2026 特化代謝のリサイクル経路がもたらすC/N/S循環システムの理解
2018 - 2020 組織破壊に依存しない植物グルコシノレートの新たな分解機構とその生理的意義の解明
2019 - 2019 特異なラジカルSAM酵素によって修飾された新規ペプチド天然物の探索

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Papers (22)：

Yohei Morishita, Suze Ma, Eugenio De La Mora, He Li, Heng Chen, Xinjian Ji, Anthony Usclat, Patricia Amara, Ryosuke Sugiyama, Yi Wei Tooh, et al. Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation. Nature Chemistry. 2024
Yuta Koseki, Hiroaki Nishimura, Ryuji Asano, Katsuyuki Aoki, Li Shiyu, Ryosuke Sugiyama, Mami Yamazaki. Isolation of new indole alkaloid triglucoside from the aqueous extract of Uncaria rhynchophylla. Journal of Natural Medicines. 2024
Takehiro Ito, Taisuke Kitaiwa, Kosuke Nishizono, Minori Umahashi, Shunsuke Miyaji, Shin-Ichiro Agake, Kana Kuwahara, Tadashi Yokoyama, Shinya Fushinobu, Akiko Maruyama-Nakashita, et al. Glutathione degradation activity of γ-glutamyl peptidase 1 manifests its dual roles in primary and secondary sulfur metabolism in Arabidopsis. The Plant journal : for cell and molecular biology. 2022
Ryosuke Sugiyama, Angelica Faith L Suarez, Yohei Morishita, Thi Quynh Ngoc Nguyen, Yi Wei Tooh, Muhammad Nur Hadi Bin Roslan, Justin Lo Choy, Qi Su, Wei Yang Goh, Gregory Adrian Gunawan, et al. The Biosynthetic Landscape of Triceptides Reveals Radical SAM Enzymes That Catalyze Cyclophane Formation on Tyr- and His-Containing Motifs. Journal of the American Chemical Society. 2022. 144. 26. 11580-11593
Ryosuke Sugiyama, Rui Li, Ayuko Kuwahara, Ryo Nakabayashi, Naoyuki Sotta, Tetsuya Mori, Takehiro Ito, Naoko Ohkama-Ohtsu, Toru Fujiwara, Kazuki Saito, et al. Retrograde sulfur flow from glucosinolates to cysteine in Arabidopsis thaliana. Proceedings of the National Academy of Sciences. 2021. 118. 22

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Patents (2)：

Peptides with Antimicrobial Properties
新規抗真菌剤

Lectures and oral presentations (14)：

シロイヌナズナ本葉における恒常型ER bodyの食害抑止機能の解析
(日本植物生理学会年会(Web) 2019)
Membrane Affinity and Biological Activities of 5aTHQs, Combined-culture Metabolites
(天然有機化合物討論会講演要旨集(Web) 2018)
New Catabolic System for Glucosinolates in Non-disrupted Plant Tissue
(天然有機化合物討論会講演要旨集(Web) 2018)
Studies on the biosynthesis of novel alkaloids derived from the combined-culture of Streptomyces nigrescens HEK616 and Tsukamurella pulmonis
(Institute for Fermentation, Osaka. Research Communications 2018)
複合培養によって生産されるテトラヒドロキノリン化合物の解析
(日本放線菌学会大会講演要旨集 2017)

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Education (3)：

2013 - 2016 Kyoto University Graduate School of Pharmaceutical Sciences
2011 - 2013 Kyoto University Graduate School of Pharmaceutical Sciences
2007 - 2011 Kyoto University Faculty of Pharmaceutical Sciences

Professional career (1)：

Ph.D. (Pharmaceutical Sciences) (Kyoto University)

Work history (7)：

2023/01 - 現在 Chiba University Graduate School of Pharmaceutical Sciences
2022/07 - 2022/12 Chiba University Graduate School of Pharmaceutical Sciences
2020/01 - 2022/12 ヒューマン・フロンティア・サイエンス・プログラム長期フェロー
2019/06 - 2022/06 シンガポール国立大学理学部薬学科訪問研究員
2019/06 - 2019/12 Japan Society for the Promotion of Science

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Awards (5)：

2024/06 - 日本薬学会生薬天然物部会令和6年度奨励研究
2024/05 - 千葉大学令和5年度薬学研究院長表彰
2023/10 - 千葉大学千葉大学先進学術賞ケミカルバイオロジーとオミクス解析を活用した機能性天然有機化合物の開拓
2022/11 - 第64回天然有機化合物討論会奨励賞 Tyr/His残基にシクロファン骨格を形成するラジカルSAM-RiPP生合成系の探索
2019/03 - Human Frontier Science Program (HFSP) Long-Term Fellowships Survival strategy of anaerobes in human microbiome using radical enzyme-assisted peptide metabolites

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