Wakabayashi Shigeo

ワカバヤシシゲオ | Wakabayashi Shigeo

Affiliation and department：
Research theme for competitive and other funds (31)：

2017 - 2020 Analysis of novel genes involved in cardiac function using iPSC-derived cardiomyocytes
2015 - 2018 Novel mechanism for energy metabolism regulated by a Ca2+-sensor protein
2015 - 2017 Study on the drug exercise therapy that is effective for cardiac hypertrophy heart failure that develops in Ca2 + load model mouse
2014 - 2017 Amplification of intracellular signaling initiated near the plasma membrane transporters
2013 - 2016 A role of neuronal calcium sensor-1 on the nuclear calcium regulation in cardiomyocytes: contribution to cardiac hypertrophy

2011 - 2014 Molecular mechanism for regulaiton of ion transporter via lipid signaling and its structural basis

2011 - 2013 Role of a pH-regulating transporter NHE1 as a novel activator of calcineurin

2010 - 2012 Molecular mechanism for regulation of ion transporter and channel by bioactive I ipids

2006 - 2010 Regulatory mechanism for interaction between membrane proton sensor and cytosolic ion sensor.

2006 - 2010 Molecular interaction and modal shift for cell sensors

2007 - 2009 Pathological roles of ion transporter/channel as therapeutic targets in muscle degenerative disease

2007 - 2008 Physiological role of NCS-1, a Ca^<2+> sensor, in the heart

2006 - 2007 Na+/H+アンチポータの機能制御複合体を構成する新規タンパク質の探索

2005 - 2007 ストレッチ感受性Ca^<2+>チャネルを標的にした筋変性疾患治療薬物の開発

2001 - 2005 Structure, function and regulation of the mammalian Na+/H+ antiporters

2002 - 2003 The Na+/H+ exchanger as a proton regulatory system : its molecular structure and transport mechanism

1999 - 2000 Structure, function and regulation of the Na^+/H^+ exchanger

1998 - 2000 A study on the mechanism of Na^+/Ca^<2+> exchange and its cellular role

1998 - 1998 新規探索因子を用いた膜イオン輸送蛋白の細胞生理機能解析

1997 - 1998 Regulation of the Na+/H+ exchanger and signal transduction

1997 - 1997 新規探索因子を用いた膜イオン輸送蛋白の細胞生理機能解析

1997 - 1997 カチオン交換輸送系の構造・機能相関の研究

1995 - 1997 Molecular Mechanism of Function of Cation Antiporters.

1996 - 1996 Na^<+/>H^+交換輸送体の構造と機能・細胞外シグナルによる活性化のメカニズム

1996 - 1996 カチオン交換輸送系の構造・機能相関の研究

1995 - 1995 Na^+/H^+交換輸送体の構造と機能-細胞外シグナルによる活性化のメカニズム

1995 - 1995 カチオン交換輸送系の構造・機能相関の研究

1994 - 1994 Na^+/H^+交換輸送体の構造と機能-細胞外シグナルによる活性化のメカニズム

1992 - 1993 Structure-function of the Na^+/H^+ exchanger : mechanism for growth factor activation

1987 - 1987 筋小胞体Caポンプの分子機作の研究

1986 - 1987 A study on ion transport systems in heart muscle

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Papers (60)：

Hirofumi Morihara, Shunichi Yokoe, Shigeo Wakabayashi, Shinji Takai. TMEM182 inhibits myocardial differentiation of human iPS cells by maintaining the activated state of Wnt/β-catenin signaling through an increase in ILK expression. FASEB BioAdvances. 2024. 6. 11. 565-579
Kenjiro Tsuruoka, Shigeo Wakabayashi, Hirofumi Morihara, Ninso Matsunaga, Yasuhito Fujisaka, Isao Goto, Akihisa Imagawa, Michio Asahi. Exacerbation of autoimmune myocarditis by an immune checkpoint inhibitor is dependent on its time of administration in mice. International journal of cardiology. 2020. 313. 67-75
Yuko Iwata, Shin Ito, Shigeo Wakabayashi, Masafumi Kitakaze. TRPV2 channel as a possible drug target for the treatment of heart failure. Laboratory investigation; a journal of technical methods and pathology. 2020. 100. 2. 207-217
Yuko Iwata, Shigeo Wakabayashi, Shin Ito, Masafumi Kitakaze. Production of TRPV2-targeting functional antibody ameliorating dilated cardiomyopathy and muscular dystrophy in animal models. Laboratory investigation; a journal of technical methods and pathology. 2020. 100. 2. 324-337
Shigeo Wakabayashi, Hirofumi Morihara, Shunichi Yokoe, Takatoshi Nakagawa, Kazumasa Moriwaki, Kiichiro Tomoda, Michio Asahi. Overexpression of Na+/H+ exchanger 1 specifically induces cell death in human iPS cells via sustained activation of the Rho kinase ROCK. The Journal of biological chemistry. 2019. 294. 51. 19577-19588

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MISC (5)：

Kenjiro Turuoka, Shigeo Wakabayashi, Ninso Matsunaga, Hirofumi Morihara, Masaaki Ii, Yasuhito Fujisaka, Isao Goto, Michio Asahi. Effect of PD-1 antibody on a mouse model for experimental autoimmune myocarditis. 18th World Congress of Basic and Clinical Pharmacology(Kyoto : 2018). 2018. WCP2018. PO4-2-20
Wuping Sun, Kunitoshi Uchida, Yoshiro Suzuki, Minji Kim, Nobuyuki Takahashi, Tsuyoshi Goto, Shigeo Wakabayashi, Teruo Kawada, Yuko Iwata, Makoto Tominaga. Absence of TRPV2 impaired BAT thermogenesis in mice. CHEMICAL SENSES. 2016. 41. 9. E218-E219
Tomoe Y. Nakamura-Nishitani, Shu Nakao, Shigeo Wakabayashi. Cardioprotective Roles of Neuronal Ca2+ Sensor-1 during Stress. BIOPHYSICAL JOURNAL. 2015. 108. 2. 609A-609A
Yuko Iwata, Yuki Katanosaka, Shigeo Wakabayashi. Na+/H+ exchange inhibitors protect against muscle degeneration in cardiomyopathic hamsters. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2006. 40. 6. 952-952
Yuki Katanosaka, Yuko Iwata, Shigeo Wakabayashi, Munekazu Shigekawa. The phosphorylation and inhibition of Na+/Ca2+ exchanger in phenylephrin-treated hypertrophic cardiomyocytes. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2006. 40. 6. 951-951

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