Research theme for competitive and other funds (11)：
2023 - 2026 骨格筋のしなやかさにおける微小管の役割
2022 - 2025 Elucidating Cellular and Molecular Mechanisms of Myoblast Fusion Using Machine Learning
2022 - 2024 Cooperative functions of myosin molecular ensembles as manifested in information theory.
2020 - 2023 Role of Microtubules in the Muscle Structure-Contraction Relationship
2018 - 2021 A novel super-resolution imaging method for capturing individual molecular dynamics in cardiac myosin ensembles
2016 - 2019 Experimental and theoretical studies on function of single and multiple molecules
2014 - 2016 Verification of cooperativity based on a single molecule measurement method to visualize the dynamics among a small number of myosin molecules.
2011 - 2016 Imaging of molecular functions in cells with nanometer accuracy and constructing models to explain them
2012 - 2015 Nano scale in vivo imaging of contractile proteins in mouse skeletal muscle
2012 - 2015 Single molecule visualization measurements linking molecular complexes and their function in individual animals.
2008 - 2009 Understanding of cooperative actions between skeletal myosin molecules
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Papers (25)：
Eiji Wada, Nao Susumu, Motoshi Kaya, Yukiko K. Hayashi. Characteristics of nuclear architectural abnormalities of myotubes differentiated from LmnaH222P/H222P skeletal muscle cells. In Vitro Cellular & Developmental Biology - Animal. 2024
Yongtae Hwang, Takumi Washio, Toshiaki Hisada, Hideo Higuchi, Motoshi Kaya. A reverse stroke characterizes the force generation of cardiac myofilaments, leading to an understanding of heart function. Proceedings of the National Academy of Sciences. 2021. 118. 23
茅元司. Coordinated Force Generation of Skeletal Myosins. 生物物理(Web). 2019. 59. 5
Yoshimi Kinoshita, Taketoshi Kambara, Kaori Nishikawa, Motoshi Kaya, Hideo Higuchi. Step Sizes and Rate Constants of Single-headed Cytoplasmic Dynein Measured with Optical Tweezers. Scientific Reports. 2018. 8. 1
Kazuo Sasaki, Motoshi Kaya, Hideo Higuchi. A Unified Walking Model for Dimeric Motor Proteins. Biophysical Journal. 2018. 115. 10. 1981-1992
Tomohiro Shima, Kohji Ito, Takahide Kon, Motoshi Kaya, Hideo Higuchi, Kazuo Sutoh. Two Motor Domains of Cytoplasmic Dynein Directly Interact Each Other. BIOPHYSICAL JOURNAL. 2011. 100. 3. 529-530
Anh H. Nguyen, Motoshi Kaya, Takahide Kon, Kazuo Sutoh, Hideo Higuchi. The contribution of individual dynein head to the processive movement of two single-headed dynein. BIOPHYSICAL JOURNAL. 2007. 526A-526A
Lectures and oral presentations (1)：
Unique Molecular Properties of Cardiac Myosin Essential for Heart Contraction
(World Congress of Biomechanics 2022)
Work history (1)：
2006/04 - 現在 The University of Tokyo Department of Physics, Graduate School of Science
