Ohtsuka Masayuki

2023 - 2026 ポリコームタンパクYAF2による大腸癌の進展、転移、再発における制御機構の解明

2023 - 2026 C5-C5aR1/2 axisを標的とした膵癌進展機構の解明と新規補体免疫賦活化療法への応用

2022 - 2025 Molecular mechanism of biliary tract carcinomas arising from patients with pancreaticobiliary malfunction

2022 - 2025 in vivoエストロゲン非依存性乳癌細胞株による内分泌療法抵抗性機序の解析研究

2022 - 2025 大腸癌におけるRYBP を介した腫瘍制御機構の解明

2021 - 2024 二重機能を有する抗酸化物質による難治性乳癌に対する新たな治療戦略

2021 - 2024 肝胆膵領域癌におけるIRG1を介した抗炎症作用に基づく新規治療戦略

2020 - 2023 膵癌進展進展機構に関わるC4BPA-CD40 axisの機能解析および治療開発

2020 - 2023 肝胆膵領域癌におけるLGR5を標的としたSTAT3活性抑制による新規治療の開発

2020 - 2023 内臓脂肪による免疫老化と慢性炎症が手術侵襲に及ぼす影響とオステオポンチンの関与

2020 - 2023 NETsを介した膵臓癌EMT-MET plasticity機構の解明

2019 - 2022 Mechanism of cancer progression mediated by IL-32-Gankyrin axis in intrahepatic cholangiocarcinoma

2019 - 2022 Tumor-suppressive role of Smad ubiquitination regulatory factor 2 in patients with colorectal cancer

2019 - 2022 Plasticity of cancer-initiating and cancer cells in intrahepatic cholangiocarcinoma and regulation of the cancer stromal microenvironment

2019 - 2022 The elucidation of mechanism underlying pancreatic cancer progression by complement and secreted proteins in tumor microenvironment.

2018 - 2021 Development of precision medicine for pancreatic cancer combining near infrared imaging and biological information

2018 - 2021 Antibody therapy using gene-transduced adipocytes for breast cancer

2017 - 2020 A new approach for avoiding age-related risks after extended hepatectomy by targeting Pin1.

2017 - 2020 Identification of biomarkers for biliary tract cancer by proteomic approaches

2016 - 2019 Role of YAP/TAZ in induction of cancer-initiating cells in cholangiocarcinoma and development of new targeting therapy

2015 - 2018 New criteria of pancreatic neuroendocrine tumors depending on expression levels of transcription factors related to neural and endocrine cell development

2014 - 2017 Identification of novel biomarkers for pancreato-biliary cancer by comprehensive protein profiling analysis

2013 - 2016 The kinetics and modulation of tumor-initiating cells regulated by cell differentiation and dedifferentiation in de novo primary liver cancer

2012 - 2015 Identification of pancreatic cancer stem cells and its interaction with surrouding stroma

2012 - 2015 Evaluation of the inhibited hepatic sinusoidal regeneration after hepatectomy in cirrhotic liver and attempt for promoting liver regeneration using endothelial progenitor cells

2011 - 2013 The strategy for reducing surgical risk by immunonutrition after severely stressful surgery

2012 - 2012 遺伝子発現、遺伝子多型からみた肝胆道領域高度侵襲手術後の感染制御の研究

2010 - 2012 Clinical heterogeneity brought about by tumor-initiating cells in primary liver cancer and the development of new therapeutic strategy by regulating microRNAs.

2009 - 2011 Evaluation of the signal transduction that controls hepatic sinusoidal regeneration and attempt to promote liver regeneration using endothelial progenitor cells.

2009 - 2010 生体肝移植および肝切除の適応拡大のための過大肝再生誘導について

2008 - 2010 Promotion of Liver Regeneration and Control of Infectious Complications after Liver Transplantation and Major Hepatectomy.

2007 - 2008 MicroRNAs and their potential for cancer development inhepatocellular and cholangiocellular carcinomas derived fromhepatic progenitor cells.

2007 - 2008 Antitumor effects and promotion of liver regeneration by controlling angiogenetic signal transduction

2007 - 2008 Mechanismsoftheinteractionbetweencancercells andmesenchymal Cells in gastroirltestinal cancer.

2006 - 2007 Regulation of organ dysfunction and infectious complications after liver transplantation : in the view of innate immunity and the Kupffer cells

2006 - 2007 A Novel Gene Therapy with Bone Marrow Stem Cell Homing

2005 - 2006 Mechanism of sinusoidal endothelial cell proliferation and maturation during hepatic regeneration

2005 - 2006 Early detection of postoperative sepsis and organ dysfunction using cDNA micro-array and therapeutic strategy for these complications by anti-TLR antibody.

2004 - 2005 Identification of factors involving chemotherapy resistance in pancreatic cancer patients by Protein Chip system for developing prediction system of chemotherapy response.

2004 - 2005 Inhibition of tumor angiogenesis through chondromodulin-I gene transfer

2003 - 2004 生体侵襲時の臓器不全発症過程におけるTLR-4およびMD-2蛋白の関与

2003 - 2004 Evaluation of Underlying Hepatic Status in Hepatocellular Carcinoma Recurrence by Oxidative Stress Markers for DNA Damage

2002 - 2003 Modification of donor MHC antigens with ribozyme RNA transfer to prevent rejection of graft liver

2001 - 2002 Cytochrome P450 and Cyclooxygenease-2 expression in liver tissue surrounding hepatocellur carcinoma : Evaluation of environmental state of multicentric hepatocarcinogenesis